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Identification of candidate biomarkers for GBM based on WGCNA
Glioblastoma multiforme (GBM), the most aggressive form of primary brain tumor, poses a considerable challenge in neuro-oncology. Despite...
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Identification of potential core genes in pseudoexfoliation using bioinformatics analysis and retrospective analysis of 84 patients with this disease
BackgroundPseudoexfoliation (XFS) is a common cause of glaucoma in nowadays. Because of XFS causing irreversible blindness secondary to glaucoma...
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Landscape of infiltrating immune cells and related genes in diabetic kidney disease
IntroductionDiabetic kidney disease (DKD) is one of the prominent microvascular complications of diabetes and the leading cause of end-stage renal...
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Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia
The TREM2–DAP12 receptor complex sustains microglia functions. Heterozygous hypofunctional TREM2 variants impair microglia, accelerating late-onset...
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Identification of key biomarkers in steroid-induced osteonecrosis of the femoral head and their correlation with immune infiltration by bioinformatics analysis
ObjectiveThis study aimed to identify key diagnostic markers and immune infiltration of (SONFH) by bioinformatics analysis.
MethodsRelated SONFH...
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Osteoclast differentiation and dynamic mRNA expression during mice embryonic palatal bone development
This study is the first to investigate the process of osteoclast (OCL) differentiation, its potential functions, and the associated mRNA and...
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Characteristics of immune clusters and cell abundance in patients with different subtypes of nonparoxysmal atrial fibrillation
Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice. Inflammation plays an important role in the initiation and...
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Effect of APOE alleles on the glial transcriptome in normal aging and Alzheimer’s disease
The roles of APOE ε4 and APOE ε2—the strongest genetic risk and protective factors for Alzheimer’s disease—in glial responses remain elusive. We tested...
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Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition
BackgroundParkinson’s disease (PD) is a neurodegenerative disorder that is characterized by the presence of proteinaceous alpha-synuclein (α-syn)...
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Identification of Immune-Related Markers in Hepatocellular Carcinoma Based on Gene Co-expression Network
Hepatocellular carcinoma (HCC) is a major cause of cancer-related death throughout the world, with constant increasing morbidity and mortality....
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Heterogeneity of circulating CD4+CD8+ double-positive T cells characterized by scRNA-seq analysis and trajectory inference
The frequency of CD4 + CD8 + double-positive (DP) T cells is highly associated with a variety of diseases. Recently, we used high-throughput single-cell...
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Exploring characteristics of placental transcriptome and cord serum metabolome associated with low birth weight in Kele pigs
The neonate with low birth weight (LBW) resulted from intrauterine growth retardation (IUGR) exists a substantial risk of postpartum death. Placental...
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Ex vivo expanded human regulatory T cells modify neuroinflammation in a preclinical model of Alzheimer’s disease
BackgroundRegulatory T cells (Tregs) play a neuroprotective role by suppressing microglia and macrophage-mediated inflammation and modulating...
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Bioinformatics analysis and identification of genes and molecular pathways in steroid-induced osteonecrosis of the femoral head
BackgroundSteroid-induced osteonecrosis of the femoral head (ONFH) is a common hip joint disease and is difficult to be diagnosed early. At present,...
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Weighted gene co-expression network analysis identifies specific modules and hub genes related to coronary artery disease
This investigation seeks to dissect coronary artery disease molecular target candidates along with its underlying molecular mechanisms. Data on...
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Identifying the hub genes for Duchenne muscular dystrophy and Becker muscular dystrophy by weighted correlation network analysis
BackgroundThe goal of this study is to identify the hub genes for Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) via weighted...
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Pathological Roles of INPP5D in Alzheimer’s Disease
Current hypothesis of Alzheimer’s disease (AD) postulates that amyloid β (Aβ) deposition in the brain causes tau inclusion in neurons and leads to...
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Long-term running exercise improves cognitive function and promotes microglial glucose metabolism and morphological plasticity in the hippocampus of APP/PS1 mice
BackgroundThe role of physical exercise in the prevention of Alzheimer’s disease (AD) has been widely studied. Microglia play an important role in...
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Machine learning prediction and tau-based screening identifies potential Alzheimer’s disease genes relevant to immunity
With increased research funding for Alzheimer’s disease (AD) and related disorders across the globe, large amounts of data are being generated....
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Comprehensive analysis of miRNA–mRNA regulatory network and potential drugs in chronic chagasic cardiomyopathy across human and mouse
BackgroundChronic chagasic cardiomyopathy (CCC) is the leading cause of heart failure in Latin America and often causes severe inflammation and...
