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Observing isolated synaptic vesicle association and fusion ex vivo
Here, we present a protocol for isolating functionally intact glutamatergic synaptic vesicles from whole-mouse brain tissue and using them in a...
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Strategy to improve synaptic behavior of ion-actuated synaptic transistors—the use of ion blocking layer to improve state retention
Synaptic transistors (STs) with a gate/electrolyte/channel stack, where mobile ions are electrically driven across the solid electrolyte, have been...
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Synaptic Effects Induced by Alcohol
Ethanol (EtOH) has effects on numerous cellular molecular targets, and alterations in synaptic function are prominent among these effects. Acute...
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High-throughput volumetric map** of synaptic transmission
Volumetric imaging of synaptic transmission in vivo requires high spatial and high temporal resolution. Sha** the wavefront of two-photon...
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Synaptic ribbon dynamics after noise exposure in the hearing cochlea
Moderate noise exposure induces cochlear synaptopathy, the loss of afferent ribbon synapses between cochlear hair cells and spiral ganglion neurons,...
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Energy consumption of spontaneous transitions in a synaptic delay network
The delays are prevalent in a variety physical and biological systems. In this paper, we study the network firing activity, energy consumption, and...
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New perspective on sustained antidepressant effect: focus on neurexins regulating synaptic plasticity
Depression is highly prevalent globally, however, currently available medications face challenges such as low response rates and short duration of...
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Synaptic loss and its association with symptom severity in Parkinson’s disease
Parkinson’s disease (PD) is the fastest growing neurodegenerative disease, but at present there is no cure, nor any disease-modifying treatments....
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CA3 hippocampal synaptic plasticity supports ripple physiology during memory consolidation
The consolidation of recent memories depends on memory replays, also called ripples, generated within the hippocampus during slow-wave sleep, and...
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Lead-free perovskites-based photonic synaptic devices with zero electric energy consumption
The von Neumann bottleneck is a critical limitation in synaptic devices. Therefore, artificial synaptic devices resembling biological neuromorphic...
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Preliminary evidence for preserved synaptic density in late-life depression
Late-life depression has been consistently associated with lower gray matter volume, the origin of which remains largely unexplained. Recent in-vivo...
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Moiré synaptic transistor with room-temperature neuromorphic functionality
Moiré quantum materials host exotic electronic phenomena through enhanced internal Coulomb interactions in twisted two-dimensional heterostructures
1 –4 ...
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Homeostatic synaptic plasticity rescues neural coding reliability
To survive, animals must recognize reoccurring stimuli. This necessitates a reliable stimulus representation by the neural code. While synaptic...
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LTP Revisited: Reconsidering the Explanatory Power of Synaptic Efficacy
Changes in synaptic strength are described as a unifying hypothesis for memory formation and storage, leading philosophers to consider the ‘synaptic...
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VAP spatially stabilizes dendritic mitochondria to locally support synaptic plasticity
Synapses are pivotal sites of plasticity and memory formation. Consequently, synapses are energy consumption hotspots susceptible to dysfunction when...
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Synapsin condensation controls synaptic vesicle sequestering and dynamics
Neuronal transmission relies on the regulated secretion of neurotransmitters, which are packed in synaptic vesicles (SVs). Hundreds of SVs accumulate...
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Electrophysiological Analysis of Synaptic Transmission
This second edition volume expands on the previous edition with discussions on the latest techniques used to study synaptic transmissions. The...
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Soft multifunctional neurological electronic skin through intrinsically stretchable synaptic transistor
Neurological electronic skin (E-skin) can process and transmit information in a distributed manner that achieves effective stimuli perception,...
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Recent Advance in Synaptic Plasticity Modulation Techniques for Neuromorphic Applications
Manipulating the expression of synaptic plasticity of neuromorphic devices provides fascinating opportunities to develop hardware platforms for...
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Synaptic Cooperation and Competition: Two Sides of the Same Coin?
Memories are not recollections of our past but rather predictions of the future. As such, memories are evolving constructs prone to modifications....