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Secretory Otitis Media
Secretory otitis media (SOM) is a pathologic condition of the middle ear in which an effusion is present behind the intact eardrum. Early diagnosis...
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Clinical Behavior and Molecular Insights of Secretory Carcinoma of Salivary Glands, a Single Center Experience
Objective: the study aimed to characterize the novel entity referred to as secretory carcinoma of the salivary glands. Methods: we comprehensively...
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NMP4, an Arbiter of Bone Cell Secretory Capacity and Regulator of Skeletal Response to PTH Therapy
The skeleton is a secretory organ, and the goal of some osteoporosis therapies is to maximize bone matrix output. Nmp4 encodes a novel transcription...
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Opisthorchis viverrini excretory-secretory products suppress GLUT8 of cholangiocytes
Opisthorchis viverrini infection and the subsequent bile duct cancer it induces remains a significant public health problem in Southeast Asia....
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Tardigrade secretory proteins protect biological structures from desiccation
Tardigrades, microscopic animals that survive a broad range of environmental stresses, express a unique set of proteins termed tardigrade-specific...
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Construction of a eukaryotic expression system with stable and secretory expression of mycobacterium tuberculosis 38 kDa protein
The 38 kDa protein is a major antigen of mycobacterium tuberculosis and has been widely used in TB serodiagnosis, due to its highly sensitivity and...
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Exogenous and Endogenous Triggers Differentially Stimulate Pigr Expression and Antibacterial Secretory Immunity in the Murine Respiratory Tract
PurposeTransport of secretory immunoglobulin A (SIgA) through the airway epithelial cell barrier into the mucosal lumen by the polymeric...
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Spatial proteomics reveals secretory pathway disturbances caused by neuropathy-associated TECPR2
Hereditary sensory and autonomic neuropathy 9 (HSAN9) is a rare fatal neurological disease caused by mis- and nonsense mutations in the gene encoding...
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High-efficiency secretory expression and characterization of the recombinant type III human-like collagen in Pichia pastoris
Collagen, the highest content protein in the body, has irreplaceable biological functions, and it is widespread concerned in food, beauty, and...
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High expression of secretory leukocyte protease inhibitor (SLPI) in stage III micro-satellite stable colorectal cancer is associated with reduced disease recurrence
Secretory leukocyte protease inhibitor (SLPI) is a pleiotropic protein produced by healthy intestinal epithelial cells. SLPI regulates NF-κB...
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Substrate topographies modulate the secretory activity of human bone marrow mesenchymal stem cells
BackgroundMesenchymal stem cells (MSCs) secrete a diversity of factors with broad therapeutic potential, yet current culture methods limit potency...
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Epigenetic activation of secretory phenotypes in senescence by the FOXQ1-SIRT4-GDH signaling
Although metabolic reprogramming is characterized as a hallmark of aging, implications of the crucial glutamate dehydrogenase (GDH) in human...
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Rab26 controls secretory granule maturation and breakdown in Drosophila
At the onset of Drosophila metamorphosis, plenty of secretory glue granules are released from salivary gland cells and the glue is deposited on the...
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Leptospiral imelysin (LIC_10713) is secretory, immunogenic and binds to laminin, fibronectin, and collagen IV
AbstractLeptospirosis is a widespread zoonotic disease caused by pathogenic Leptospira . Early and accurate diagnosis is the prime step in managing...
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Screening of immune-related secretory proteins linking chronic kidney disease with calcific aortic valve disease based on comprehensive bioinformatics analysis and machine learning
BackgroundChronic kidney disease (CKD) is one of the most significant cardiovascular risk factors, playing vital roles in various cardiovascular...
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PTHrP induces STAT5 activation, secretory differentiation and accelerates mammary tumor development
BackgroundParathyroid hormone-related protein (PTHrP) is required for embryonic breast development and has important functions during lactation, when...
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A hemolysin secretion pathway-based novel secretory expression platform for efficient manufacturing of tag peptides and anti-microbial peptides in Escherichia coli
BackgroundAlthough Escherichia coli has been widely used for the expression of exogenous proteins, the secretory expression in this system is still...
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Smoking modulates different secretory subpopulations expressing SARS-CoV-2 entry genes in the nasal and bronchial airways
SARS-CoV-2 infection and disease severity are influenced by viral entry (VE) gene expression patterns in the airway epithelium. The similarities and...
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Senescence-associated secretory phenotypes in mesenchymal cells contribute to cytotoxic immune response in oral lichen planus
Oral lichen planus is a chronic inflammatory condition that adversely affects the oral mucosa; however, its etiology remains elusive. Consequently,...
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The role of QRFP43 in the secretory activity of the gonadotrophic axis in female sheep
In mammals reproduction is regulated by many factors, among others by the peptides belonging to the RFamide peptide family. However, the knowledge...
