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Improved intravenous lentiviral gene therapy based on endothelial-specific promoter-driven factor VIII expression for hemophilia A
BackgroundHemophilia A (HA) is an X-linked monogenic disorder caused by deficiency of the factor VIII ( FVIII ) gene in the intrinsic coagulation...
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Optical Quadruple New Gate Using SLM and Savart Plate
Reversible logic is increasing importance to several future computing technologies for the last three decades. Optical logic gates become an...
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Impact of the Coolant Flow Velocity on the Thermal Condition of Flat-Plate Solar Collectors
The issues of effective operation of flat-plate solar collectors in the Voronezh region and under other RF climatic conditions have been considered....
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Numerical study on the behaviour of resilient beam-column end plate connection with dual structural fuse
The beam-column connections are generally failed due to geometrical and material properties of connection under seismic conditions. Towards damage...
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Enhancement of the haemostatic effect of platelets in the presence of high normal concentrations of von Willebrand factor for critically ill patients needing platelet transfusion—a protocol for the will-plate randomised controlled trial
Introductionvon Willebrand Factor (vWF) is a key protein mediating platelet adhesion on the surface of damaged endothelia. To the best of our...
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Strength Analysis of a Plate Heat Exchanger with Two Design-By-Analysis Methods
Plate heat exchangers are widely used equipment in engineering. As the structure of the equipment is complicated, it is hard to perform accurate...
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Late Bajocian and Early Bathonian Ostracods of the Russian Plate. Part III. Genera Camptocythere Triebel and Procytheridea Peterson
AbstractA new species Camptocythere ( Anabarocythere ) triangula Tesakova, sp. nov. is described from the Upper Bajocian ( Michalskii ammonite Zone)...
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Late Bajocian and Early Bathonian Ostracods of the Russian Plate. Part IV. The Lineage Glyptocythere aspera (Khabarova) → G. bathonica sp. nov.
AbstractAn extended and updated redescription of the stratigraphically important species Glyptocythere aspera (Khabarova, 1955) from the Upper...
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Thermal Diffusion and Thermal Radiation Effects on Free Convective MHD Radiating Flow Past an Impulsively Started Infinite Vertical Plate
An exact solution to the problem of a free convective MHD radiating chemically reacting non-gray optically thick flow of incompressible fluid past a...
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Buckling Restrained Braces - Issues and Solutions
This paper describes some design issues relating to buckling restrained braced frames (BRBFs) including: (i) BRB system capacity under both axial...
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Experimental analysis of solar air heater duct with discrete arc-pattern combined staggered element roughness on absorber plate
Providing artificial roughness over absorber surface of solar air heater ( SAH ) is the most economical and effective way of enhancing its performance....
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Microtiter plate assays to assess antibiofilm activity against bacteria
Bacterial biofilms demonstrate high broad-spectrum adaptive antibiotic resistance and cause two thirds of all infections, but there is a lack of...
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Modeling and vibration analysis of a spinning assembled beam–plate structure reinforced by graphene nanoplatelets
The theoretical modeling of a functionally graded (FG) graphene nanoplatelet (GPL)-reinforced assembled beam–plate structure resting on elastic...
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Destructive Intraplate Earthquakes in Arabia—The Archeoseismological Evidence
The Arabian Plate is surrounded by seismically highly active margins, while the plate interior is seemingly aseismic. To add unknown events to the...
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Ultra-sensitive AAV capsid detection by immunocapture-based qPCR following factor VIII gene transfer
Adeno-associated virus (AAV)-based gene therapy vectors are replication-incompetent and thus pose minimal risk for horizontal transmission or release...
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In Vitro Biological Evaluation of Some Synthesized Novel 5-Substituted-2-(substituted)hydazineyl-1,3-thiazolidin-4-ones
AbstractThe 2-[2-(1-(4-chlorophenyl)ethylidene]hydrazineyl-1,3-thiazolidin-4-one ( V ) compound was synthesized via the condensation of...
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Localization of Eigenfunctions in a Narrow Kirchhoff Plate
AbstractThe asymptotics of eigenvalues and eigenfunctions of the Dirichlet problem for the biharmonic operator in a narrow two-dimensional domain (a...
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The Latest Structural Plan of the West Siberian Plate
AbstractStructural–geomorphological analysis of the territory of the West Siberian Plate allowed us to establish its latest structural plan....
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VIII: Postlude: Specific Questions at the Margins of Human Life
As a postlude, this chapter addresses several rather specific and technical questions and concerns that are sometimes levelled against the definition...
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A plate-based single-cell ATAC-seq workflow for fast and robust profiling of chromatin accessibility
Profiling chromatin accessibility at the single-cell level provides critical information about cell type composition and cell-to-cell variation...
