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Structural anisotropy results in mechano-directional transport of proteins across nuclear pores
The nuclear pore complex regulates nucleocytoplasmic transport by means of a tightly synchronized suite of biochemical reactions. The physicochemical...
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N2FXm, a method for joint nuclear and cytoplasmic volume measurements, unravels the osmo-mechanical regulation of nuclear volume in mammalian cells
In eukaryotes, cytoplasmic and nuclear volumes are tightly regulated to ensure proper cell homeostasis. However, current methods to measure...
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Influence of hydrogen import prices on hydropower systems in climate-neutral Europe
While climate and energy policy targets require fundamental changes and expansions in the energy infrastructure, hydropower systems across Europe...
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Integration of FUNDC1-associated mitochondrial protein import and mitochondrial quality control contributes to TDP-43 degradation
Though TDP-43 protein can be translocated into mitochondria and causes mitochondrial damage in TDP-43 proteinopathy, little is known about how TDP-43...
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A Simple Method for the Detection of Wybutosine-Modified tRNAPheGAA as a Readout of Retrograde tRNA Nuclear Import and Re-export: HCl/Aniline Cleavage and Nonradioactive Northern Hybridization
tRNAs are highly mobile molecules that are trafficked back and forth between the nucleus and cytoplasm by several proteins. However, characterization...
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Potential for the Implementation of the Policy of Develo** Import Substitution in Industry within the Budget Constraints 2023–2025
Abstract—The article continues the study of the possibilities of implementing the strategy of develo** import substitution in the machine-building...
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IPO11 regulates the nuclear import of BZW1/2 and is necessary for AML cells and stem cells
AML cells are arranged in a hierarchy with stem/progenitor cells giving rise to more differentiated bulk cells. Despite the importance of...
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Inhibition of Kpnβ1 mediated nuclear import enhances cisplatin chemosensitivity in cervical cancer
BackgroundInhibition of nuclear import via Karyopherin beta 1 (Kpnβ1) shows potential as an anti-cancer approach. This study investigated the use of...
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Identification of a nuclear localization signal mediating the nuclear import of Arabidopsis splicing factor1
The splicing factor1 protein (SF1) is involved in branch point recognition of pre-mRNA introns during the early stages of spliceosome assembly in the...
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IGF-1R nuclear import and recruitment to chromatin involves both alpha and beta subunits
Mature type 1 insulin-like growth factor receptors (IGF-1Rs) are heterotetrameric structures comprising two extracellular α-subunits...
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Structural basis for nuclear import selectivity of pioneer transcription factor SOX2
SOX (SRY-related HMG-box) transcription factors perform critical functions in development and cell differentiation. These roles depend on precise...
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Inter-organellar and systemic responses to impaired mitochondrial matrix protein import in skeletal muscle
Effective protein import from cytosol is critical for mitochondrial functions and metabolic regulation. We describe here the mammalian...
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The LINC Complex Assists the Nuclear Import of Mechanosensitive Transcriptional Regulators
Mechanical forces play pivotal roles in directing cell functions and fate. To elicit gene expression, either intrinsic or extrinsic mechanical...
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HNF1A-MODY Mutations in Nuclear Localization Signal Impair HNF1A-Import Receptor KPNA6 Interactions
Mutations in hepatocyte nuclear factor (HNF)1A gene cause the most common form of Maturity-onset diabetes of the young (MODY), a monogenic subtype of...
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Cytosolic retention of HtrA2 during mitochondrial protein import stress triggers the DELE1-HRI pathway
Mitochondrial stress inducers such as carbonyl cyanide m-chlorophenyl hydrazone (CCCP) and oligomycin trigger the DELE1-HRI branch of the integrated...
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Neddylation of PTEN regulates its nuclear import and promotes tumor development
PTEN tumor suppressor opposes the PI3K/Akt signaling pathway in the cytoplasm and maintains chromosomal integrity in the nucleus. Nucleus–cytoplasm...
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Recapitulation of selective nuclear import and export with a perfectly repeated 12mer GLFG peptide
The permeability barrier of nuclear pore complexes (NPCs) controls nucleocytoplasmic transport. It retains inert macromolecules while allowing...
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Types of nuclear localization signals and mechanisms of protein import into the nucleus
Nuclear localization signals (NLS) are generally short peptides that act as a signal fragment that mediates the transport of proteins from the...
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SRY-Box transcription factor 9 triggers YAP nuclear entry via direct interaction in tumors
The translocation of YAP from the cytoplasm to the nucleus is critical for its activation and plays a key role in tumor progression. However, the...
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LASS2 enhances p53 protein stability and nuclear import to suppress liver cancer progression through interaction with MDM2/MDMX
LASS2 functions as a tumor suppressor in hepatocellular carcinoma (HCC), the most common type of primary liver cancer, but the underlying mechanism...
