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Chromatin as a key consumer in the metabolite economy
In eukaryotes, chromatin remodeling and post-translational modifications (PTMs) shape the local chromatin landscape to establish permissive and...
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Mitochondrial proteome research: the road ahead
Mitochondria are multifaceted organelles with key roles in anabolic and catabolic metabolism, bioenergetics, cellular signalling and nutrient...
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Exercise-induced cardiac mitochondrial reorganization and enhancement in spontaneously hypertensive rats
The myocardium is a highly oxidative tissue in which mitochondria are essential to supply the energy required to maintain pump function. When...
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Advances in Metal-Based Compounds as Emerging Therapeutics for Cancer Treatment
This chapter explores the transformative role of metal-based compounds in diverse cancer treatment strategies. Metal complexes enhance immunotherapy...
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Early Vascular Aging in Young Adults Is Instrumental as the Screening Tool to Combat CVD Epidemics in the Population
Cardiovascular diseases (CVD) remain the leading causes of death worldwide. Moreover, rejuvenation of morbidity and mortality from CVD is widely...
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From spreading depolarization to blood–brain barrier dysfunction: navigating traumatic brain injury for novel diagnosis and therapy
Considerable strides in medical interventions during the acute phase of traumatic brain injury (TBI) have brought improved overall survival rates....
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Mitochondrial mechanisms in the pathogenesis of chronic inflammatory musculoskeletal disorders
Chronic inflammatory musculoskeletal disorders characterized by prolonged muscle inflammation, resulting in enduring pain and diminished...
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Mitochondrial transplantation as a potential and novel master key for treatment of various incurable diseases
Mitochondria are attractive cellular organelles which are so interesting in both basic and clinical research, especially after it was found that they...
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Striated preferentially expressed gene deficiency leads to mitochondrial dysfunction in develo** cardiomyocytes
A deficiency of striated preferentially expressed gene ( Speg ), a member of the myosin light chain kinase family, results in abnormal myofibril...
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Mitofusins: from mitochondria to fertility
Germ cell formation and embryonic development require ATP synthesized by mitochondria. The dynamic system of the mitochondria, and in particular, the...
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Guided U-Net Aided Efficient Image Data Storing with Shape Preservation
The proliferation of high-content microscopes ( \(\sim \) 32...
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20-Deoxyingenol Activates Mitophagy Through TFEB and Promotes Functional Recovery After Spinal Cord Injury
Spinal cord injury (SCI) can lead to permanent paralysis and various motor, sensory and autonomic nervous system dysfunction. The complex...
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Anatomy and Physiology of the Skin
The skin is the outermost and largest organ making up almost a fifth of the weight of the human body. Important functions of the skin are protection,...
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Copper in Cancer: from transition metal to potential target
In recent years, with the continuous in-depth exploration of the molecular mechanisms of tumorigenesis, numerous potential new targets for cancer...
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How the Social Gets Under the Skin: From the Social as Signal to Society as a Metabolic Milieu
Inflammation has risen to the forefront of biomedical research into many chronic diseases prevalent in industrialized countries, including mental,...
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Brain Energy Problem
Until recently, it was common sense that the brain’s energy is obtained only from glucose. However, accumulating evidence shows that glucose alone...
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Multiple Roles of Apolipoprotein E4 in Oxidative Lipid Metabolism and Ferroptosis During the Pathogenesis of Alzheimer’s Disease
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease worldwide and has a great socio-economic impact. Modified oxidative lipid...
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Defective Mitophagy and the Etiopathogenesis of Alzheimer’s Disease
As far as dementia goes, Alzheimer’s disease (AD) is the most prevalent. The disease is gradual, starting with mild memory loss and potentially...
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Mitochondrial complex III deficiency drives c-MYC overexpression and illicit cell cycle entry leading to senescence and segmental progeria
Accumulating evidence suggests mitochondria as key modulators of normal and premature aging, yet whether primary oxidative phosphorylation (OXPHOS)...
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Directed proton transfer from Fo to F1 extends the multifaceted proton functions in ATP synthase
The role of protons in ATP synthase is typically considered to be energy storage in the form of an electrochemical potential, as well as an operating...
