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Carnosine regulation of intracellular pH homeostasis promotes lysosome-dependent tumor immunoevasion
Tumor cells and surrounding immune cells undergo metabolic reprogramming, leading to an acidic tumor microenvironment. However, it is unclear how...
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Burkholderia pseudomallei biofilm resists Acanthamoeba sp. grazing and produces 8-O-4′-diferulic acid, a superoxide scavenging metabolite after passage through the amoeba
Burkholderia pseudomallei , an etiological agent of melioidosis is an environmental bacterium that can survive as an intracellular pathogen. The...
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Metabolite itaconate in host immunoregulation and defense
Metabolic states greatly influence functioning and differentiation of immune cells. Regulating the metabolism of immune cells can effectively...
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Simultaneous probing of dual intracellular metabolites (ATP and paramylon) in live microalgae using graphene oxide/aptamer nanocomplex
The development of an intracellular metabolite imaging platform for live microorganisms has been a challenge in the study of microbes. Herein, we...
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Advanced Systems and Bioreactors for Large-Scale Secondary Metabolite Production in Medicinal Plants Using Suspension Cultured Cells
In recent years, there has been extensive research on large-scale plant secondary metabolite production systems and bioreactors for various...
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PeakDecoder enables machine learning-based metabolite annotation and accurate profiling in multidimensional mass spectrometry measurements
Multidimensional measurements using state-of-the-art separations and mass spectrometry provide advantages in untargeted metabolomics analyses for...
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Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition
The gut microbiota play a pivotal role in human health. Emerging evidence indicates that gut microbes participate in the progression of tumorigenesis...
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Aromatic secondary metabolite production from glycerol was enhanced by amino acid addition in Pichia pastoris
AbstractAromatic secondary metabolites are widely used in various industries, including the nutraceutical, dietary supplement, and pharmaceutical...
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Nutrient-depended metabolic switching during batch cultivation of Streptomyces coelicolor explored with absolute quantitative mass spectrometry-based metabolite profiling
The well-known secondary metabolite-producing bacterium Streptomyces coelicolor is a natural choice for the development of super-hosts optimized for...
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Altered metabolomic states elicited by Flg22 and FlgII-28 in Solanum lycopersicum: intracellular perturbations and metabolite defenses
BackgroundSurveillance of potential pathogens is a key feature of plant innate immunity. For non-self-recognition plants rely on the perception of...
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A novel method to detect intracellular metabolite alterations in MCF-7 cells by doxorubicin induced cell death
BackgroundMetabolic reprogramming within cancer cells has been recognized as a potential barrier to chemotherapy. Additionally, metabolic tumor...
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Anti-fibrotic effect of aurocyanide, the active metabolite of auranofin
Drug repositioning has gained significant attention over the past several years. The anti-rheumatoid arthritis drug auranofin has been investigated...
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The role of soluble adenylyl cyclase in sensing and regulating intracellular pH
Soluble adenylyl cyclase (sAC) differs from transmembrane adenylyl cyclases (tmAC) in many aspects. In particular, the activity of sAC is not...
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1H-NMR metabolomics analysis identifies hypoxanthine as a novel metastasis-associated metabolite in breast cancer
Breast cancer is one of the leading causes of death in females, mainly because of metastasis. Oncometabolites, produced via metabolic reprogramming,...
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Serum metabolite signatures of cardiac function and morphology in individuals from a population-based cohort
BackgroundChanges in serum metabolites in individuals with altered cardiac function and morphology may exhibit information about cardiovascular...
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Secondary metabolite gene clusters from the phytopathogenic fungus Gaeumannomyces tritici
The take-all disease is one of the most important maladies in cereals and grasses, being caused by the fungus Gaeumannomyces tritici . Secondary...
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Metabolite profiling of plant growth promoting cyanobacteria—Anabaena laxa and Calothrix elenkinii, using untargeted metabolomics
The metabolite profiles of two plant growth promoting cyanobacteria— Anabaena laxa and Calothrix elenkinii , which serve as promising biofertilizers,...
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Bitter taste receptor activation by cholesterol and an intracellular tastant
Bitter taste sensing is mediated by type 2 taste receptors (TAS2Rs (also known as T2Rs)), which represent a distinct class of G-protein-coupled...
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An exercise-inducible metabolite that suppresses feeding and obesity
Exercise confers protection against obesity, type 2 diabetes and other cardiometabolic diseases
1 –5 . However, the molecular and cellular mechanisms...
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Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P
Pyroptosis is a type of regulated cell death executed by gasdermin family members. However, how gasdermin-mediated pyroptosis is negatively regulated...
