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A case of strongly suspected Lynch syndrome with colorectal neuroendocrine carcinoma
BackgroundNeuroendocrine cell carcinomas (NEC) of the colon and rectum are uncommon, representing ~ 0.1% of all colorectal carcinomas. They are...
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An Update on Appendiceal Neuroendocrine Tumors
The mainstay of appendiceal neuroendocrine neoplasm (aNEN) treatment is surgery, based on simple appendectomy or right-sided hemicolectomy with...
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World Health Organization grading classification for pancreatic neuroendocrine neoplasms: a comprehensive analysis from a large Chinese institution
BackgroundPancreatic neuroendocrine neoplasms (p-NENs) are a group of highly heterogeneous tumors with distinct clinicopathological features and...
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Pathology of Pancreatic Neuroendocrine Tumors
Pancreatic neuroendocrine neoplasms (PanNENs) are rare tumors derived from pancreatic neuroendocrine cells. Recently, the World Health Organization...
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Management of type 1 gastric neuroendocrine tumors: an 11-year retrospective single-center study
BackgroundType 1 gastric neuroendocrine tumors (NETs) are relatively rare to the extent that some physicians have little experience in diagnosing and...
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Validation and modification of staging Systems for Poorly Differentiated Pancreatic Neuroendocrine Carcinoma
BackgroundThe American Joint Committee on Cancer (AJCC) and the European Neuroendocrine Tumor Society (ENETS) staging classifications are two broadly...
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Prognostic differences in grading and metastatic lymph node pattern in patients with small bowel neuroendocrine tumors
PurposeNeuroendocrine tumors of the small intestine (si-NET) describe a heterogenous group of neoplasms. Based on the Ki67 proliferation index si-NET...
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Neuroendocrine Neoplasm Imaging and Image-Guided Therapies
This chapter details the nature of gastroenteropancreatic neuroendocrine tumours, specified to the different anatomical regions of appearance. This...
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New Concepts in Pathology
Neuroendocrine neoplasms (NENs) originate from the diffuse neuroendocrine system and, therefore, can arise in every part of the body. In two-thirds...
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Pancreatic Neuroendocrine Tumors: Diagnosis, Management, and Intraoperative Techniques
Pancreatic neuroendocrine tumors (pNETs) represent up to 2% of all pancreatic neoplasms and are classified as functional or non-functioning (>50%)....
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Small Intestine and Appendix
The small intestine is a complex and very efficient organ. The primary function of the small intestine is to digest and absorb the food elements that...
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Surgical and Endoscopic Resection of Duodenal Neuroendocrine Tumors Have Similar Disease-Specific Survival Outcome
BackgroundDuodenal neuroendocrine tumors (dNETs) are rare, and their management is not well-defined. National Comprehensive Cancer Network (NCCN)...
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Appendix Neoplasms
Pathology of the vermiform appendix is commonly encountered by surgeons, most frequently in patients presenting with acute appendicitis. After...
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Development and validation of a survival prediction model and risk stratification for pancreatic neuroendocrine neoplasms
PurposeWe explored risk variables associated with cancer-specific survival (CSS) in patients with pancreatic neuroendocrine neoplasms (PNENs) and...
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Bronchial carcinoid: a neuroendocrine manifestation—presented as bronchospasm and hypertension during resection
Bronchopulmonary carcinoid tumors are rare, slow-growing malignant neuroendocrine tumors. Early diagnosis is pivotal as surgical resection is the...
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The real-world selection of first-line systemic therapy regimen for metastatic gastroenteropancreatic neuroendocrine neoplasm in Japan
In November 2013, the first edition of evidence-based guidelines for treatment of gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN) was...
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Sporadic and MEN1-related gastrinoma and Zollinger–Ellison syndrome: differences in clinical characteristics and survival outcomes
PurposeGastrinoma with Zollinger–Ellison syndrome (ZES) may occur sporadically (Sp) or as part of the inherited syndrome of multiple endocrine...
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Prognostic factors after resection of locally advanced non-functional pancreatic neuroendocrine neoplasm: an analysis from the German Cancer Registry Group of the Society of German Tumor Centers
ObjectiveThe available literature regarding outcome after pancreatic resection in locally advanced non-functional pNEN (LA-pNEN) is sparse....
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Pathology of Neuroendocrine Lesions of GI Tract
Neuroendocrine neoplasms of the gastrointestinal tract (GIT) present a challenge to clinicians as well as to pathologists. Their nomenclature,...
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Value of [68Ga]Ga-somatostatin receptor PET/CT in the grading of pulmonary neuroendocrine (carcinoid) tumours and the detection of disseminated disease: single-centre pathology-based analysis and review of the literature
BackgroundAlthough most guidelines suggest performing a positron emission tomography/computed tomography (PET/CT) with somatostatin receptor (SSTR)...
