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Inhibition of CK2 Diminishes Fibrotic Scar Formation and Improves Outcomes After Ischemic Stroke via Reducing BRD4 Phosphorylation
Fibrotic scars play important roles in tissue reconstruction and functional recovery in the late stage of nervous system injury. However, the...
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Roles of Metastasis Suppressor Gene, OGR1 and Casein Kinase 2 \(\alpha\) Intronless Gene, CSNK2A3 in Megakaryocytic Differentiation
Casein Kinase 2 \(\alpha\) (CK2...
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CK2 activity is crucial for proper glucagon expression
Aims/hypothesisProtein kinase CK2 acts as a negative regulator of insulin expression in pancreatic beta cells. This action is mainly mediated by...
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GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway
Preserving cells in a functional, non-senescent state is a major goal for extending human healthspans. Model organisms reveal that longevity and...
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Nucleus-exported CLOCK acetylates PRPS to promote de novo nucleotide synthesis and liver tumour growth
Impairment of the circadian clock is linked to cancer development. However, whether the circadian clock is modulated by oncogenic receptor tyrosine...
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Targeting CK2-mediated phosphorylation of p53R2 sensitizes BRCA-proficient cancer cells to PARP inhibitors
Poly[ADP-ribose] polymerase (PARP) inhibitors, which selectively kills homologous recombination (HR) repair-deficient cancer cells, are widely...
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Effect of histidine protonation state on ligand binding at the ATP-binding site of human protein kinase CK2
Histidine residues contribute to numerous molecular interactions, owing to their structure with the ionizable aromatic side chain with pK a close to...
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Roles of NOLC1 in cancers and viral infection
BackgroundThe nucleolus is considered the center of metabolic control and an important organelle for the biogenesis of ribosomal RNA (rRNA)....
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Protein kinase CK2 – diverse roles in cancer cell biology and therapeutic promise
The association of protein kinase CK2 (formerly casein kinase II or 2) with cell growth and proliferation in cells was apparent at early stages of...
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Protein kinase 2 (CK2) controls CD4+ T cell effector function in the pathogenesis of colitis
Crohn’s disease (CD), one of the major forms of inflammatory bowel disease (IBD), is characterized by chronic inflammation of the gastrointestinal...
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Influence of CK2 protein kinase activity on the interaction between Trypanosoma cruzi and its vertebrate and invertebrate hosts
Chagas disease, endemic from Latin America, is caused by Trypanosoma cruzi and is transmitted by triatomine feces. This parasite undergoes complex...
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CIGB-300 anticancer peptide regulates the protein kinase CK2-dependent phosphoproteome
Casein-kinase CK2 is a Ser/Thr protein kinase that fosters cell survival and proliferation of malignant cells. The CK2 holoenzyme, formed by the...
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Hypoxia switches TET1 from being tumor-suppressive to oncogenic
The classical oxidizing enzymatic activity of Ten Eleven Translocation 1 (TET1) and its tumor suppressor role are well known. Here, we find that high...
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Pharmacological attenuation of melanoma by tryptanthrin pertains to the suppression of MITF-M through MEK/ERK signaling axis
Melanoma is the most aggressive among all types of skin cancers. The current strategies against melanoma utilize BRAF V600E , as a focal point for...
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Protein kinase CK2 phosphorylates a conserved motif in the Notch effector E(spl)-Mγ
Across metazoan animals, the effects of Notch signaling are mediated via the Enhancer of Split (E(spl)/HES) basic Helix–Loop–Helix–Orange (bHLH-O)...
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Phosphoproteomics revealed cellular signals immediately responding to disruption of cancer amino acid homeostasis induced by inhibition of l-type amino acid transporter 1
BackgroundCancer-upregulated l -type amino acid transporter 1 (LAT1; SLC7A5) supplies essential amino acids to cancer cells. LAT1 substrates are not...
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Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors
CK2 is a constitutively active protein kinase overexpressed in numerous malignancies. Interaction between CK2α and CK2β subunits is essential for...
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P21-activated kinase 1 (PAK1)-mediated cytoskeleton rearrangement promotes SARS-CoV-2 entry and ACE2 autophagic degradation
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has had a significant...
