Search
Search Results
-
TRAFIC: statistical design and analysis plan for a pragmatic early phase 1/2 Bayesian adaptive dose escalation trial in rheumatoid arthritis
BackgroundAdaptive model-based dose-finding designs have demonstrated advantages over traditional rule-based designs but have increased statistical...
-
Cone beam CT-based adaptive intensity modulated proton therapy assessment using automated planning for head-and-neck cancer
BackgroundTo assess the feasibility of CBCT-based adaptive intensity modulated proton therapy (IMPT) using automated planning for treatment of head...
-
A flexible dose-response modeling framework based on continuous toxicity outcomes in phase I cancer clinical trials
BackgroundThe past few decades have seen remarkable developments in dose-finding designs for phase I cancer clinical trials. While many of these...
-
The radiation adaptive response and priming dose influence: the quantification of the Raper–Yonezawa effect and its three-parameter model for postradiation DNA lesions and mutations
The priming dose effect, called also the Raper–Yonezawa effect or simply the Yonezawa effect, is a special case of the radiation adaptive response...
-
Model-Based Designs for Identification of Optimal Biological Dose
This chapter presents several model-based phase I/II designs, including the EffTox design (Thall & Cook, 2004), the logistic model-based design (Zang...
-
Deep reinforcement learning for data-driven adaptive scanning in ptychography
We present a method that lowers the dose required for an electron ptychographic reconstruction by adaptively scanning the specimen, thereby providing...
-
Identification of an optimal dose of intravenous ketamine for late-life treatment-resistant depression: a Bayesian adaptive randomization trial
Evidence supporting specific therapies for late-life treatment-resistant depression (LL-TRD) is necessary. This study used Bayesian adaptive...
-
Utility-Based Dose Selection for Phase II Dose-Finding Studies
Background and ObjectivesDose selection is a key feature of clinical development. Poor dose selection has been recognized as a major driver of...
-
SFU: Surface-Free Utility-Based Design for Dose Optimization in Cancer Drug Combination Trials
Precision oncology has demonstrated the potential of drug combinations in effectively enhancing anti-tumor efficiency and controlling disease...
-
Is more better? An analysis of toxicity and response outcomes from dose-finding clinical trials in cancer
BackgroundThe overwhelming majority of dose-escalation clinical trials use methods that seek a maximum tolerable dose, including rule-based methods...
-
Pareto Adaptive Robust Optimality via a Fourier–Motzkin Elimination lens
We formalize the concept of Pareto Adaptive Robust Optimality (PARO) for linear two-stage Adaptive Robust Optimization (ARO) problems, with fixed...
-
Assessment of interfraction dose variation in pancreas SBRT using daily simulation MR images
Pancreatic Cancer is associated with poor treatment outcomes compared to other cancers. High local control rates have been achieved by using...
-
Bayesian Adaptive Designs for Phase I Trials
Phase I trials mark the first experimentation of a new drug or combination of drugs in a human population. The primary aim of a cancer phase I trial...
-
Interaction dynamics between innate and adaptive immune cells responding to SARS-CoV-2 vaccination in non-human primates
As SARS-CoV-2 variants continue evolving, testing updated vaccines in non-human primates remains important for guiding human clinical practice. To...
-
Model-Assisted Designs for Identifying the Optimal Biological Dose
Compared to the model-assisted designs introduced in Chapter 4, model-based designs are complicated statistically and computationally, making them...
-
Effects of Low Dose Ionizing Radiation on Human Health: Evidence for Revisiting Radiation Protection Policies
The impact of low-dose ionizing radiation exposures on human health has involved extensive debate over the past few decades. Despite accumulating...
-
Association of effective dose to immune cells and vertebral marrow dose with hematologic toxicity during neoadjuvant chemoradiotherapy in esophageal squamous cell carcinoma
BackgroundTo explore the correlation between effective dose to immune cells (EDIC) and vertebral bone marrow dose and hematologic toxicity (HT) for...
-
CBCT-based synthetic CT generated using CycleGAN with HU correction for adaptive radiotherapy of nasopharyngeal carcinoma
This study aims to utilize a hybrid approach of phantom correction and deep learning for synthesized CT (sCT) images generation based on cone-beam CT...
-
A multicenter, dose-finding, phase 1b study of imatinib in combination with alpelisib as third-line treatment in patients with advanced gastrointestinal stromal tumor
BackgroundAcquired resistance to approved tyrosine kinase inhibitors limits their clinical use in patients with gastrointestinal stromal tumor...
-
Ketogenic diet for epilepsy control and enhancement in adaptive behavior
The Ketogenic Diet (KD) is gaining attention as a management line in childhood drug resistant epilepsy (DRE). The objective of this study was to...
