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Dysregulated Wnt/β-catenin signaling confers resistance to cuproptosis in cancer cells
Cuproptosis is characterized by the aggregation of lipoylated enzymes of the tricarboxylic acid cycle and subsequent loss of iron-sulfur cluster...
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Autotaxin Inhibition Reduces Post‐Ischemic Myocardial Inflammation via Epigenetic Gene Modifications
Myocardial infarction (MI) triggers a complex inflammatory response that is essential for cardiac repair but can also lead to adverse outcomes if...
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The evolving landscape of publishing in human reproduction: an analysis of scientometric data, open-access publishing, and article processing charges
BackgroundThis bibliometric study aims to examine the associations of journals in the field of human reproduction with their access types and article...
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IDH1-mutant metabolite D-2-hydroxyglutarate inhibits proliferation and sensitizes glioma to temozolomide via down-regulating ITGB4/PI3K/AKT
The heterogeneous molecular subtypes of gliomas demonstrate varied responses to chemotherapy and distinct prognostic outcomes. Gliomas with...
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Simultaneous de novo calling and phasing of genetic variants at chromosome-scale using NanoStrand-seq
The successful accomplishment of the first telomere-to-telomere human genome assembly, T2T-CHM13, marked a milestone in achieving completeness of the...
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Derivation of two iPSC lines (KAIMRCi004-A, KAIMRCi004-B) from a Saudi patient with Biotin-Thiamine-responsive Basal Ganglia Disease (BTBGD) carrying homozygous pathogenic missense variant in the SCL19A3 gene
The neurometabolic disorder known as biotin-thiamine-responsive basal ganglia disease (BTBGD) is a rare autosomal recessive condition linked to...
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Applications of extraembryonic tissue-derived cells in vascular tissue regeneration
Vascular tissue engineering is a promising approach for regenerating damaged blood vessels and develo** new therapeutic approaches for heart...
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Evaluation of the association of polymorphisms of the vitamin D receptor gene (VDR) with idiopathic recurrent pregnancy loss among women in Kazakhstan
BackgroundThere is considerable global discourse on the impact of insufficient vitamin D levels, known for their immunosuppressive properties, on...
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Map** the chromatin accessibility landscape of zebrafish embryogenesis at single-cell resolution by SPATAC-seq
Currently, the dynamic accessible elements that determine regulatory programs responsible for the unique identity and function of each cell type...
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Extracellular Microvesicles vs. Mitochondria: Competing for the Top Spot in Cardiovascular Regenerative Medicine
Regenerative medicine aims to restore, replace, and regenerate human cells, tissues, and organs. Despite significant advancements, many cell therapy...
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The combination of temozolomide and perifosine synergistically inhibit glioblastoma by impeding DNA repair and inducing apoptosis
Temozolomide (TMZ) is widely utilized as the primary chemotherapeutic intervention for glioblastoma. However, the clinical use of TMZ is limited by...
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The roles of neural stem cells in myelin regeneration and repair therapy after spinal cord injury
Spinal cord injury (SCI) is a complex tissue injury that results in a wide range of physical deficits, including permanent or progressive...
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Extracellular Vesicles from Adipose Tissue-Derived Stromal Cells Stimulate Angiogenesis in a Scaffold-Dependent Fashion
Background:The extracellular vesicles (EVs) secreted by adipose tissue-derived stromal cells (ASC) are microenvironment modulators in tissue...
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Histone H2A deubiquitinase BAP1 is essential for endothelial cell differentiation from human pluripotent stem cells
Polycomb group proteins (PcGs) add repressive post translational histone modifications such as H2AK119ub1, and histone H2A deubiquitinases remove it....
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Role of Neurotransmitters in Steady State Hematopoiesis, Aging, and Leukemia
Haematopoiesis within the bone marrow (BM) represents a complex and dynamic process intricately regulated by neural signaling pathways. This delicate...
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A single-cell atlas of chromatin accessibility in mouse organogenesis
Organogenesis is a highly complex and precisely regulated process. Here we profiled the chromatin accessibility in >350,000 cells derived from 13...
