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Platelet-Rich Plasma Promotes the Expansion of Human Myoblasts and Favors the In Vitro Generation of Human Muscle Reserve Cells in a Deeper State of Quiescence
Stem cell therapy holds significant potential for skeletal muscle repair, with in vitro-generated human muscle reserve cells (MuRCs) emerging as a...
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PET Images Enhancement Using Deep Training of Reconstructed Images with Bayesian Penalized Likelihood Algorithm
PurposeTo adopt the merits of the Bayesian Penalized Likelihood (BPL) reconstruction algorithm (incl. improved contrast recovery), a deep learning...
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Modified mesenchymal stromal cells by in vitro transcribed mRNA: a therapeutic strategy for hepatocellular carcinoma
BackgroundMesenchymal stromal cells (MSCs) tropism for tumours allows their use as carriers of antitumoural factors and in vitro transcribed mRNA...
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Autotaxin Inhibition Reduces Post‐Ischemic Myocardial Inflammation via Epigenetic Gene Modifications
Myocardial infarction (MI) triggers a complex inflammatory response that is essential for cardiac repair but can also lead to adverse outcomes if...
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Possible Drug Repurposing and Accelerated Wound Healing
PurposeHealing of a wound is a multifaceted process that involves several factors to be considered for proper completion. Improper healing of wounds...
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Applications of extraembryonic tissue-derived cells in vascular tissue regeneration
Vascular tissue engineering is a promising approach for regenerating damaged blood vessels and develo** new therapeutic approaches for heart...
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Antibacterial, Antioxidant, and Healing Potential of Wound Dressings Utilizing Cranberry Extract in Combination with Methacrylated Polyvinyl Alcohol and Methacrylated Sericin
PurposeHydrogels, due to their hydrophilic nature and tunable properties, have emerged as promising materials for wound dressings. Notably, the...
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Extracellular Microvesicles vs. Mitochondria: Competing for the Top Spot in Cardiovascular Regenerative Medicine
Regenerative medicine aims to restore, replace, and regenerate human cells, tissues, and organs. Despite significant advancements, many cell therapy...
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The roles of neural stem cells in myelin regeneration and repair therapy after spinal cord injury
Spinal cord injury (SCI) is a complex tissue injury that results in a wide range of physical deficits, including permanent or progressive...
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Extracellular Vesicles from Adipose Tissue-Derived Stromal Cells Stimulate Angiogenesis in a Scaffold-Dependent Fashion
Background:The extracellular vesicles (EVs) secreted by adipose tissue-derived stromal cells (ASC) are microenvironment modulators in tissue...
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IRTKS Elevation in Patients with Colon Cancer and the Curative Influences of Hamsc Secretome on Polarity and Invasion of HT-29 Colon Cancer Cells
PurposeColon cancer is a major contributor (fifth one) to cancer-related deaths in the world. For the unique characteristics of stem cells, stem...
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Role of Neurotransmitters in Steady State Hematopoiesis, Aging, and Leukemia
Haematopoiesis within the bone marrow (BM) represents a complex and dynamic process intricately regulated by neural signaling pathways. This delicate...
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Rankl genetic deficiency and functional blockade undermine skeletal stem and progenitor cell differentiation
BackgroundSkeletal Stem Cells (SSCs) are required for skeletal development, homeostasis, and repair. The perspective of their wide application in...
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Preclinical Therapeutic Efficacy of Extracellular Vesicles Derived from Adipose-Derived Mesenchymal Stromal/Stem Cells in Diabetic Wounds: a Systematic Review and Meta-Analysis
Extracellular vesicles isolated from adipose tissue-derived mesenchymal stromal/stem cells (ADSC-EVs) have demonstrated promising potential in wound...
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Essential role of p21Waf1/Cip1 in the modulation of post-traumatic hippocampal Neural Stem Cells response
BackgroundTraumatic Brain Injury (TBI) represents one of the main causes of brain damage in young people and the elderly population with a very high...
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Decoding cellular plasticity and niche regulation of limbal stem cells during corneal wound healing
BackgroundDysfunction or deficiency of corneal epithelium results in vision impairment or blindness in severe cases. The rapid and effective...
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New advances of NG2-expressing cell subset in marrow mesenchymal stem cells as novel therapeutic tools for liver fibrosis/cirrhosis
BackgroundBone marrow-derived mesenchymal stem cell ( BM MSC)-based therapy has become a major focus for treating liver fibrosis/cirrhosis. However,...
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Comparative effectiveness of mesenchymal stem cell versus bone-marrow mononuclear cell transplantation in heart failure: a meta-analysis of randomized controlled trials
BackgroundThere is no clear evidence on the comparative effectiveness of bone-marrow mononuclear cell (BMMNC) vs. mesenchymal stromal cell (MSC) stem...
