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eIF4A1 enhances LARP1-mediated translational repression during mTORC1 inhibition
Eukaryotic translation initiation factor (eIF)4A—a DEAD-box RNA-binding protein—plays an essential role in translation initiation. Recent reports...
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Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution
Channel enzymes represent a class of ion channels with enzymatic activity directly or indirectly linked to their channel function. We investigated a...
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To slide or not to slide: key role of the hexasome in chromatin remodeling revealed
Hexasomes are non-canonical nucleosomes that package DNA with six instead of eight histones. First discovered 40 years ago as a consequence of...
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RNAi screens identify HES4 as a regulator of redox balance supporting pyrimidine synthesis and tumor growth
NADH/NAD + redox balance is pivotal for cellular metabolism. Systematic identification of NAD(H) redox regulators, although currently lacking, would...
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Structure and mechanism of lysosome transmembrane acetylation by HGSNAT
Lysosomal transmembrane acetylation of heparan sulfates (HS) is catalyzed by HS acetyl-CoA:α-glucosaminide N -acetyltransferase (HGSNAT), whose...
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Unwinding of a eukaryotic origin of replication visualized by cryo-EM
To prevent detrimental chromosome re-replication, DNA loading of a double hexamer of the minichromosome maintenance (MCM) replicative helicase is...
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Prevalence and risk factor for H9N2 avian influenza virus in poultry retail shops of Madhya Pradesh
H9N2 avian Influenza virus subtype is highly neglected but have the potential to emerge as a next pandemic influenza virus, by either itself...
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The LexA–RecA* structure reveals a cryptic lock-and-key mechanism for SOS activation
The bacterial SOS response plays a key role in adaptation to DNA damage, including genomic stress caused by antibiotics. SOS induction begins when...
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Epidemiological and clinical profile of HTLV-1 patients: a closer look at a reference center in Bahia, Brazil
The human T-lymphotropic virus type 1 (HTLV-1) affects over 5 million people worldwide and is endemic in Brazil. Though HTLV-1 is a notifiable...
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An evaluation of nucleic acid-based molecular methods for the detection of plant viruses: a systematic review
Precise and timely diagnosis of plant viruses is a prerequisite for the implementation of efficient management strategies, considering factors like...
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Computational design of non-porous pH-responsive antibody nanoparticles
Programming protein nanomaterials to respond to changes in environmental conditions is a current challenge for protein design and is important for...
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Cryo-EM structure of the Rev1–Polζ holocomplex reveals the mechanism of their cooperativity in translesion DNA synthesis
Rev1–Polζ-dependent translesion synthesis (TLS) of DNA is crucial for maintaining genome integrity. To elucidate the mechanism by which the two...
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Target-based discovery of a broad-spectrum flukicide
Diseases caused by parasitic flatworms impart a considerable healthcare burden worldwide. Many of these diseases—for example, the parasitic blood...
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Deregulated DNA ADP-ribosylation impairs telomere replication
The recognition that DNA can be ADP ribosylated provides an unexpected regulatory level of how ADP-ribosylation contributes to genome stability,...
