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Trastuzumab-Deruxtecan: Redefining HER2 as a Tumor Agnostic Biomarker
Trastuzumab deruxtecan (T-DXd) is an antibody-drug conjugate (ADC) targeting HER2-positive malignancies across various tumor types. Through its...
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New horizons for the role of selenium on cognitive function: advances and challenges
Cognitive deficits associated with oxidative stress and the dysfunction of the central nervous system are present in some neurodegenerative diseases,...
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Differential Adherence to Free and Single-Pill Combination of Rosuvastatin/Ezetimibe: Findings from a Real-World Analysis in Italy
IntroductionAdherence to cardiovascular drug treatment can significantly benefit from a reduced pill burden, but data on this matter derived from...
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Characteristics of adult retroperitoneal lymphangioma: a single center Chinese cohort study of 15 cases
BackgroundLymphangioma is a rare cystic tumor that occurs across different locations. Retroperitoneal lymphangioma accounts for about 1% of all...
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Contrast-enhanced mammography for surveillance in women with a personal history of breast cancer
PurposeWomen with a personal history of breast cancer have an increased risk of subsequent breast malignancy and may benefit from more sensitive...
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Comprehensive multiomics analysis of the signatures of gastric mucosal bacteria and plasma metabolites across different stomach microhabitats in the development of gastric cancer
PurposeAs an important component of the microenvironment, the gastric microbiota and its metabolites are associated with tumour occurrence,...
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Polyamine and EIF5A hypusination downstream of c-Myc confers targeted therapy resistance in BRAF mutant melanoma
BackgroundBRAF inhibitors are widely employed in the treatment of melanoma with the BRAF V600E mutation. However, the development of resistance...
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Comorbidities and survival of multiple myeloma patients diagnosed in Finland between 2000 and 2021
Advances in treatment have improved the survival of multiple myeloma (MM) patients, but the disease remains incurable. Here, in this nationwide...
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Zinc Oxide Nanoparticles Attenuated Neurochemical and Histopathological Alterations Associated with Aluminium Chloride Intoxication in Rats
The present investigation explored the potential neuroprotective role of zinc oxide nanoparticles (ZnONPs) on aluminum chloride (AlCl 3 )-mediated...
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Standardized reporting for Head CT Scans in patients suspected of traumatic brain injury (TBI): An international expert endeavor
Background and purposeTraumatic brain injury (TBI) is a major source of health loss and disability worldwide. Accurate and timely diagnosis of TBI is...
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Image quality of whole-body diffusion MR images comparing deep-learning accelerated and conventional sequences
ObjectivesTo compare the image quality of deep learning accelerated whole-body (WB) with conventional diffusion sequences.
MethodsFifty consecutive...
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Effect of Hepatic Impairment on Trofinetide Exposures Using an In Silico Physiologically Based Pharmacokinetic Model
IntroductionTrofinetide is the first drug to be approved for the treatment of Rett syndrome. Hepatic impairment is not expected to affect the...
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3D airway geometry analysis of factors in airway navigation failure for lung nodules
BackgroundThis study aimed to quantitatively reveal contributing factors to airway navigation failure during radial probe endobronchial ultrasound...
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Systematic review-based guideline “Parkinson’s disease” of the German Society of Neurology: diagnostic use of transcranial sonography
Background and objectiveTranscranial brain parenchyma sonography (TCS) has been recommended as a tool for the early and differential diagnosis of...
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Establishment of a nomogram to predict the overall survival of patients with collecting duct renal cell carcinoma
BackgroundCollecting duct carcinoma (CDC) is a rare histological type of renal cell carcinoma that lacks a prognostic prediction model. In this...
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PANoptosis-based molecular subtype and prognostic model predict survival and immune landscape in esophageal cancer
PurposeTo establish a prognostic model to predict the survival of patients with esophageal cancer (EC).
MethodsWe extracted the expression profiles...
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Associations of three differential white blood cell counts, platelet counts, and their derived inflammatory indices with cancer-related fatigue in patients with breast cancer undergoing chemotherapy
PurposeInflammation is thought to be a vital element in the etiology of cancer-related fatigue (CRF), and circulating blood cell parameters could be...
