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Comparison of the diagnostic significance of cerebrospinal fluid metagenomic next-generation sequencing copy number variation analysis and cytology in leptomeningeal malignancy
BackgroundDiagnosis and monitoring of leptomeningeal malignancy remain challenging, and are usually based on neurological, radiological,...
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Protocol for the MS-CEBA study: an observational, prospective cohort study identifying Cognitive, Energetic, Behavioural and Affective (CEBA) profiles in Multiple Sclerosis to guide neuropsychological treatment choice
BackgroundNeuropsychological symptoms in the Cognitive, Energetic, Behavioural, and Affective (CEBA) domains are common in people with multiple...
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Construction and validation of a brain magnetic resonance imaging template for normal older Koreans
BackgroundSpatial normalization to a standardized brain template is a crucial step in magnetic resonance imaging (MRI) studies. Brain templates made...
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Ketogenic Diets Alter the Gut Microbiome, Resulting in Decreased Susceptibility to and Cognitive Impairment in Rats with Pilocarpine-Induced Status Epilepticus
A ketogenic diet (KD) is a high-fat, low-carbohydrate, and low-protein diet that exerts antiepileptic effects by attenuating spontaneous recurrent...
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Incident traumatic spinal cord injury and risk of Alzheimer’s disease and related dementia: longitudinal case and control cohort study
Study designRetrospective case/control longitudinal cohort study
ObjectivesPrevalent traumatic spinal cord injury (TSCI) is associated with...
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Sex-specific implications of inflammation in covert cerebral small vessel disease
BackgroundThe relationship between inflammation and covert cerebral small vessel disease (SVD) with regards to sex difference has received limited...
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FOXA1 Suppresses Endoplasmic Reticulum Stress, Oxidative Stress, and Neuronal Apoptosis in Parkinson's Disease by Activating PON2 Transcription
Endoplasmic reticulum (ER) stress and oxidative stress (OS) are often related states in pathological conditions including Parkinson's disease (PD)....
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Incidence of Parkinson’s disease in Germany based on prevalence data from 70 million patients of the statutory health insurance
BackgroundParkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by motor and nonmotor system manifestations and...
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Therapeutic Potential of Fingolimod on Psychological Symptoms and Cognitive Function in Neuropsychiatric and Neurological Disorders
Neuropsychiatric and neurological disorders pose a significant global health burden, highlighting the need for innovative therapeutic approaches....
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Atherosclerosis is associated with plasma Aβ levels in non-hypertension patients
BackgroundGrowing evidence indicated that to develop of atherosclerosis observed more often by people with Alzheimer’s disease (AD), but the...
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Study protocol for the MIND-PD study: a randomized controlled trial to investigate clinical and biological effects of mindfulness-based cognitive therapy in people with Parkinson’s disease
BackgroundPeople with Parkinson’s disease (PD) are very sensitive to the effects of stress. The prevalence of stress-related neuropsychiatric...
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Association of total sleep duration variability with risk of new stroke in the middle-aged and elderly Chinese population
ObjectiveTo investigate the association between total sleep duration variability and stroke in the middle-aged and elderly population in China.
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HDAC1 Promotes Mitochondrial Pathway Apoptosis and Inhibits the Endoplasmic Reticulum Stress Response in High Glucose-Treated Schwann Cells via Decreased U4 Spliceosomal RNA
Dysfunction of Schwann cells, including cell apoptosis, autophagy inhibition, dedifferentiation, and pyroptosis, is a pivotal pathogenic factor in...
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The association between abcb1 gene polymorphism and clopidogrel response variability in stroke ischemic: a cross sectional study
BackgroundClopidogrel has been the primary choice of antiplatelet in ischemic stroke that inhibits adenosine diphosphate (ADP)-induced platelet...
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A Dutch cost-effectiveness analysis of fremanezumab versus best supportive care in patients with chronic migraine and inadequate response to prior preventive therapy
BackgroundChronic migraine (CM) is the most severe and burdensome subtype of migraine. Fremanezumab is a monoclonal antibody that targets the...
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Spinal cord injury etiology, severity, and care in East Asia: a cross-sectional analysis of the International Spinal Cord Society Database Project
Study designCross-sectional study.
ObjectivesTo evaluate etiologic factors associated with spinal cord injury (SCI) severity and to identify...
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Perceptions and attitudes regarding complementary, alternative, and integrative medicine among published neurology authors: a large-scale, international cross-sectional survey
BackgroundWhile many patients with neurological disorders and conditions use complementary, alternative, and integrative medicine (CAIM), little is...
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Microglia and Astrocytes Responses Contribute to Alleviating Inflammatory Damage by Repetitive Transcranial Magnetic Stimulation in Rats with Traumatic Brain Injury
Repetitive transcranial magnetic stimulation (rTMS) is a therapeutic strategy that shows promise in ameliorating the clinical sequelae following...
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Randomized controlled trial of intermittent hypoxia in Parkinson’s disease: study rationale and protocol
BackgroundParkinson’s disease (PD) is a neurodegenerative disease for which no disease-modifying therapies exist. Preclinical and clinical evidence...
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Correlation of bilateral M1 hand area excitability and overall functional recovery after spinal cord injury: protocol for a prospective cohort study
BackgroundAfter spinal cord injury (SCI), a large number of survivors suffer from severe motor dysfunction (MD). Although the injury site is in the...
