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TCBIR/CD320: a potential therapeutic target upregulated in endothelial cells and associated with immune cell infiltration in liver hepatocellular carcinoma
CD320, which is a transmembrane protein responsible for facilitating the absorption of vitamin B12, plays a key role in this process. However, the...
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Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial
Preclinical evidence demonstrates that senescent cells accumulate with aging and that senolytics delay multiple age-related morbidities, including...
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SARS-CoV-2-related peptides induce endothelial-to-mesenchymal transition in endothelial capillary cells derived from different body districts: focus on membrane (M) protein
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV‐2), responsible for the COVID-19, may lead to multiple organ dysfunctions and long-term...
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Benefits for children with suspected cancer from routine whole-genome sequencing
Clinical whole-genome sequencing (WGS) has been shown to deliver potential benefits to children with cancer and to alter treatment in high-risk...
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Impact of SOFC anode carbon deposition and hydrogen adsorption on the cell performance by molecular simulation
ContextThis study primarily investigates the changes in carbon adsorption capacity and hydrogen adsorption capacity on the anode catalyst surface...
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LncRNA TRPM2-AS promotes endometrial carcinoma progression and angiogenesis via targeting miR-497-5p/SPP1 axis
BackgroundAnti-angiogenic therapy has become one of the effective treatment methods for tumors. Long noncoding RNAs (lncRNAs) are emerging as...
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Exploring the role of microRNAs as diagnostic and prognostic biomarkers in canine mammary tumors
Canine mammary tumors (CMTs) represent a significant health concern in dogs, with a high incidence among intact female dogs. CMTs are a promising...
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Neoadjuvant chemotherapy with or without camrelizumab in resectable esophageal squamous cell carcinoma: the randomized phase 3 ESCORT-NEO/NCCES01 trial
Recent single-arm studies involving neoadjuvant camrelizumab, a PD-1 inhibitor, plus chemotherapy for resectable locally advanced esophageal squamous...
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ESCCPred: a machine learning model for diagnostic prediction of early esophageal squamous cell carcinoma using autoantibody profiles
BackgroundEsophageal squamous cell carcinoma (ESCC) is a deadly cancer with no clinically ideal biomarkers for early diagnosis. The objective of this...
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The value of 68Ga-PSMA PET/CT in the diagnosis of intracapsular prostate cancer with a poor prognosis
ObjectiveTo evaluate the diagnostic value of 68 Ga-prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography...
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Recent advances in two-dimensional perovskite materials for light-emitting diodes
Light-emitting diodes (LEDs) are an indispensable part of our daily life. After being studied for a few decades, this field still has some room for...
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Extended lifespan in female Drosophila melanogaster through late-life calorie restriction
Calorie restriction has many beneficial effects on healthspan and lifespan in a variety of species. However, how late in life application of caloric...
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Alteration of Piezo1 signaling in type 2 diabetic mice: focus on endothelium and BKCa channel
Piezo1 mechanosensitive ion channel plays a important role in vascular physiology and disease. This study aimed to elucidate the altered signaling...
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Genetic and environmental determinants of bone quality: a cross-sectional analysis of the Hungarian Twin Registry
There is abundant evidence that bone mineral content is highly heritable, while the heritability of bone quality (i.e. trabecular bone score [TBS]...
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The heterogeneity of erythroid cells: insight at the single-cell transcriptome level
Erythroid cells, the most prevalent cell type in blood, are one of the earliest products and permeate through the entire process of hematopoietic...
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Exploring Bacillus species xylanases for industrial applications: screening via thermostability and reaction modelling
ContextXylanases derived from Bacillus species hold significant importance in various large-scale production sectors, with increasing demand driven...
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Metformin improves cognitive dysfunction through SIRT1/NLRP3 pathway–mediated neuroinflammation in db/db mice
Diabetes mellitus (DM), an important public health problem, aggravates the global economic burden. Diabetic encephalopathy (DE) is a serious...
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Healthcare system resilience and adaptability to pandemic disruptions in the United States
Understanding healthcare system resilience has become paramount, particularly in the wake of the COVID-19 pandemic, which imposed unprecedented...
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Integrating molecular pathway with genome-wide association data for causality identification in breast cancer
ObjectiveThe study purpose was to explore the causal association between pyruvate metabolism and breast cancer (BC), as well as the molecular role of...
