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Retroperitoneal leakage as an important cause of acquired ultrafiltration decline in peritoneal dialysis: clinical characteristics and related risk factors
BackgroundPeritoneal dialysis (PD) is a widely-used renal replacement therapy while low ultrafiltration volume usually results in technique failure....
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Functions of Rab GTPases in organelle biogenesis
Rab GTPases regulate diverse aspects of the biogenesis of secretory and endocytic organelles. The conformational changes that accompany GTP binding...
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Introduction: Regulatory processes, an emerging feature in intracellular membrane traffic
The subject of this volume is the molecular mechanism of the intracellular membrane trafficking, a central eukaryotic cell biological process. In the...
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Biophysical characterization of the phase separation of TDP-43 devoid of the C-terminal domain
BackgroundFrontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-TDP), amyotrophic lateral sclerosis (ALS) and limbic-predominant...
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Bilateral renal agenesis: fetal intervention and outcomes
Bilateral renal agenesis (BRA) is a fetal anomaly which leads to anhydramnios and resultant pulmonary hypoplasia. Historically, this anomaly was...
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Advanced Targeting Strategies for Murine Retroviral and Adeno-associated Viral Vectors
Targeted gene delivery involves broadening viral tropism to infect previously nonpermissive cells, replacing viral tropism to infect a target cell...
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Nonviral Delivery of Cancer Genetic Vaccines
The potential use of genetic vaccines to address numerous diseases including cancer is promising, but currently unrealized. Here, we review...
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Production and Formulation of Adenovirus Vectors
Adenovirus vectors have attracted considerable interest over the past decade, with ongoing clinical development programs for applications ranging...
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Molecular Conjugates
Molecular conjugates are nanometer-sized entities consisting of synthetic materials (lipids, polycations, targeting agents, and so on) and nucleic...
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Regulation of SNARE assembly by protein phosphorylation
Protein phosphorylation is emerging as an important regulatory mechanism that controls the secretory pathway. It enables coupling between the...
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Molecular mechanisms in clathrin-mediated membrane budding
Clathrin-coated vesicles (CCVs) form at the plasma membrane where they select cargo for endocytic entry into cells. CCVs also form at the trans-Golgi...
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Tethering proteins in membrane traffic
In eukaryotic cells, protein secretion and the transport of materials between membrane-bounded organelles require efficient and accurate delivery of...
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Regulation of exocytotic events by centrosome-analogous structures
Centrosomes, spindle pole bodies, and related structures, generally termed microtubule organising centres (MTOCs; Pickett-Heaps 1969), are best...
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Exploring the complexity of EEG patterns in Parkinson’s disease
Parkinson’s disease (PD) is a progressive neurodegenerative disorder primarily associated with motor dysfunctions. By the time of definitive...
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A review of the genetic background in complicated WT1-related disorders
The Wilms tumor 1 ( WT1 ) gene was first identified in 1990 as a strong candidate for conferring a predisposition to Wilms tumor. The WT1 protein has...
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Progress and perspectives of metabolic biomarkers in human aortic dissection
BackgroundAortic dissection (AD) significantly threated human cardiovascular health, extensive clinical-scientific research programs have been...
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Lentiviral Vectors
We review the use of lentiviral vectors in current human gene therapy applications that involve genetic modification of nondividing tissues with...
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Plasmid Vaccines and Therapeutics: From Design to Applications
In the late 1980s, Vical and collaborators discovered that the injection into tissues of unformulated plasmid encoding various proteins resulted in...