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PEGylation of Proteins as Tailored Chemistry for Optimized Bioconjugates
The high potential of peptides and proteins as therapeutic agents has not been fully exploited because of their common shortcomings: the only...
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Polymer Therapeutics for Cancer: Current Status and Future Challenges
Drug delivery systems for cancer therapeutics have revolutionized medicine. Delivery systems have improved the efficacy and reduced the toxicity of...
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Polymer Therapeutics: Polymers as Drugs, Drug and Protein Conjugates and Gene Delivery Systems: Past, Present and Future Opportunities
As the 21st century begins we are witnessing a paradigm shift in medical practice. Whereas the use of polymers in biomedical materials applications...
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Polypeptide and Polypeptide Hybrid Copolymer Synthesis via NCA Polymerization
This article summarizes recent developments in the synthesis of polypeptides and hybrid peptide copolymers. Traditional methods used to polymerize...
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Gene Delivery Using Polymer Therapeutics
The use of polymers as synthetic non-viral carriers for introducing nucleic acids into cells appears very appealing. Polymers can be generated in...
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Hydrogels for Musculoskeletal Tissue Engineering
The advancements in scaffold-supported cell therapy for musculoskeletal tissue engineering have been truly dramatic in the last couple of decades....
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Solution Properties of Polypeptide-based Copolymers
The aggregation behaviour of biomimetic polypeptide hybrid copolymers and copolypeptides is here reviewed with a particular eye on the occurrence...
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Nanostructured Devices Based on Block Copolymer Assemblies for Drug Delivery: Designing Structures for Enhanced Drug Function
Block copolymers spontaneously assemble into nanoscaled polymeric micelles, which have significant potential as drug carriers. Following much work...
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Asymmetric Processes Catalyzed by Chiral (Salen)Metal Complexes
A wide variety of highly selective asymmetric reactions catalyzed by chiral (salen)metal complexes have been disclosed over the past decade. Salen...
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Sparteine as a Chiral Ligand for Asymmetric Catalysis
While the use of stoichiometric amounts of sparteine and related ligands in various asymmetric reactions often lead to highly enantioselective...
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Octahedral Zirconium Complexes as Polymerization Catalysts
The synthesis and X-ray structure of various octahedral zirconium complexes and their catalytic properties in the polymerization of α-olefins are...
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Between Objectivity and Whim: Nucleic Acid Structural Biology
Here we explore the subjectivity intrinsic to macromolecular crystallography, focusing on the hydration/counter-ion region of nucleic acids. Water...
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Development of Technetium-99m and Rhenium-188 Radiopharmaceuticals Containing a Terminal Metal–Nitrido Multiple Bond for Diagnosis and Therapy
The chemistry of nitrido complexes of technetium has played an important role in the search of new Tc-99m radiopharmaceuticals and in providing...
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Hydrozirconation and Its Applications
Next to hydroboration and hydrostannylation, hydrozirconation is among the few general methods available for the stoichiometric conversion of readily...
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Progress in the Asymmetric Synthesis of 1,2-Diamines from Azomethine Compounds
Recent advances in the preparation of optically pure 1,2-diamines by stereoselective addition reactions to azomethine compounds (imines, iminium...
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Ruthenium-Catalyzed C–C Bond Formation
Molecular ruthenium catalysts are now currently used to perform selective carbon–carbon bond formation by combination of simple substrates. Their...
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Cycloaddition Reactions of Group 6 Fischer Carbene Complexes
Group 6 heteroatom-stabilised carbene complexes (Fischer carbene complexes) offer many interesting possibilities to build rings (carbocycles and...
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Regeneration of Articular Cartilage
Loss of articular cartilage from the ends of bones forming diarthrodial joints can be the source of profound pain and disability, and eventually lead...
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Aminoglycoside–Nucleic Acid Interactions: The Case for Neomycin
Aminoglycoside antibiotics are bactericidal drugs that have been at the forefront of antimicrobial therapy for almost five decades. The past decade...
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Monitoring Multidrug Resistance P-Glycoprotein Drug Transport Activity with Single-Photon Emission Computed Tomography and Positron Emission Tomography Radiopharmaceuticals
Multidrug resistance (MDR) mediated by overexpression of MDR1 P-glycoprotein (Pgp) is one of the best characterized transporter-mediated barriers to...