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Glutathione-mediated redox regulation in Cryptococcus neoformans impacts virulence
The fungal pathogen Cryptococcus neoformans is well adapted to its host environment. It has several defence mechanisms to evade oxidative and...
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Quantifying functional redundancy in polysaccharide-degrading prokaryotic communities
BackgroundFunctional redundancy (FR) is widely present, but there is no consensus on its formation process and influencing factors. Taxonomically...
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A new tau dephosphorylation-targeting chimera for the treatment of tauopathies
Abnormal accumulation of hyperphosphorylated tau protein plays a pivotal role in a collection of neurodegenerative diseases named tauopathies,...
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Exploring the biofilm inhibitory potential of Candida sp. UFSJ7A glycolipid on siliconized latex catheters
Biosurfactants, sustainable alternatives to petrochemical surfactants, are gaining attention for their potential in medical applications. This study...
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Genetic Evaluation of the Patients with Clinically Diagnosed Inborn Errors of Immunity by Whole Exome Sequencing: Results from a Specialized Research Center for Immunodeficiency in Türkiye
Molecular diagnosis of inborn errors of immunity (IEI) plays a critical role in determining patients’ long-term prognosis, treatment options, and...
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Physicochemical characterization of the brown pigment produced by Azospirillum brasilense HM053 using tryptophan as precursor
Microorganisms are known to be a promising source of biopigments because they are easy to obtain, can be produced on a commercial scale, and are...
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Liver autotransplantation and atrial reconstruction on a patient with multiorgan alveolar echinococcosis: a case report
BackgroundAlveolar echinococcosis (AE) primarily affects the liver and potentially spreads to other organs. Managing recurrent AE poses significant...
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High Expression of miR-218-5p in the Peripheral Blood Stream and Tumor Tissues of Pediatric Patients with Sarcomas
Sarcomas are malignant tumors that may metastasize and the course of the disease is highly aggressive in children and young adults. Because of the...
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Oral HPV infection clearance and acquisition after nonavalent vaccination in men who have sex with men and transgender women: a prospective analysis
Oral HPV infection is the main risk factor for the development of oropharyngeal carcinoma. Men who have sex with men (MSM), especially if living with...
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A modified mycobacterial growth inhibition assay for the functional assessment of vaccine-mediated immunity
The Mycobacterial growth inhibition assay (MGIA) is an ex-vivo assay used to measure the overall functional immune response elicited by infection or...
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Candida albicans in the oral cavities of pets: biofilm formation, putative virulence, antifungal resistance profiles and classification of the isolates
The study aimed to investigate Candida albicans presence, antifungal resistance, biofilm formation, putative virulence genes, and molecular...
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Gene-centered metagenome analysis of Vulcano Island soil (Aeolian archipelago, Italy) reveals diverse microbial key players in methane, hydrogen and sulfur cycles
The Aeolian archipelago is known worldwide for its volcanic activity and hydrothermal emissions, of mainly carbon dioxide and hydrogen sulfide....
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Epidemiology of Citrobacter spp. infections among hospitalized patients: a systematic review and meta-analysis
BackgroundInfections due to Citrobacter species are increasingly observed in hospitalized patients and are often multidrug-resistant. Yet, the...
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Test-treat-track-test-treat (5T) approach for Schistosoma haematobium elimination on Pemba Island, Tanzania
BackgroundAfter decades of praziquantel mass drug administration (MDA), several countries approach schistosomiasis elimination. Continuing MDA in...
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Serotype distribution, antibiotic resistance, multilocus sequence ty**, and virulence factors of invasive and non-invasive Streptococcus pneumoniae in Northeast China from 2000 to 2021
Streptococcus pneumoniae infection is a major public health concern with high morbidity and mortality rates. This study aimed to evaluate the...
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Mesobacterium hydrothermale sp. nov., isolated from shallow-sea hydrothermal systems off Kueishantao Island
A Gram-negative, rod-shaped, non-motile, aerobic bacterium, designated as strain TK19101 T , was isolated from the intermediate seawater of yellow vent...
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Presence and mRNA Expression of the sar Family Genes in Clinical and Non-clinical (Healthy Conjunctiva and Healthy Skin) Isolates of Staphylococcus epidermidis
Staphylococcus aureus possesses sar family genes, including sar A, S, R, T, U, V, X, Y, Z, and rot , which are transcription factors involved in...
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Clinical-laboratory characteristics predictive of COVID-19 severity: a prospective hospital cohort, in Pernambuco, Northeast Brazil
ObjectiveTo describe the clinical-laboratory profile and analyze the factors associated with the severity of COVID-19.
MethodsA prospective cohort...
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Genetic Correlation of HBB, HFE and HAMP Genes to Endocrinal Complications in Egyptian Beta Thalassemia Major Patients
Iron loading is regarded as the primary cause of endocrine abnormalities in thalassemia major patients. Thus, the purpose of the current research was...
