Search
Search Results
-
Heart Valve Regeneration
The valves of the heart cannot regenerate spontaneously. Therefore, heart valve disease generally necessitates surgical repair or replacement of the...
-
Simultaneous In Vivo Regeneration of Neodermis, Epidermis, and Basement Membrane
Full-thickness skin loss does not undergo complete spontaneous regeneration in mammals. To restore the normal function of skin, dermal and epidermal...
-
Ricin: structure, synthesis, and mode of action
Ricin is a lectin produced by the seeds of the Ricinus communis plant. It is potently toxic to mammalian cells, where it acts to inhibit the...
-
Adeno-associated Virus as a Gene Therapy Vector: Vector Development, Production and Clinical Applications
Adeno-associated virus (AAV) has emerged as an attractive vector for gene therapy. AAV vectors have successfully been utilized to promote...
-
Lentiviral Vectors
We review the use of lentiviral vectors in current human gene therapy applications that involve genetic modification of nondividing tissues with...
-
Plasmid Vaccines and Therapeutics: From Design to Applications
In the late 1980s, Vical and collaborators discovered that the injection into tissues of unformulated plasmid encoding various proteins resulted in...
-
ExoU: A cytotoxin delivered by the type III secretion system of Pseudomonas aeruginosa
ExoU is a potent cytotoxin that is injected into host cells by the type III secretion system of Pseudomonas aeruginosa. It has recently been shown to...
-
Anthrax toxin and genetic aspects regulating its expression
Anthrax toxin is a unique, tripartite bacterial toxin, capable of causing edema and lethality through binary combinations of protective antigen (PA)...
-
Peripheral Nerve Regeneration
The nerve chamber model has dominated the experimental study of peripheral nerve (PN) regeneration with animal models as well as in several clinical...
-
Kluyveromyces lactis zymocin and other plasmid-encoded yeast killer toxins
Supported by an endogenous killer plasmid DNA system that codes for an anti-proliferative zymocin toxin, the dairy yeast Kluyveromyces lactis has...
-
Staphylococcal alpha-toxin
Staphylococcal alpha-toxin, archetype of an oligomerizing pore-forming toxin, is produced and secreted as a water-soluble 34 kD monomer. High...
-
Shiga toxins and their mechanisms of cell entry
The Shiga toxins (Stxs) are related toxins secreted by Shigella dysenteriae, Escherichia coli in addition to other bacteria. They all act by entering...
-
Liver Regeneration
This review summarizes the functional aspects, cellular kinetics and molecular mechanisms related to liver regeneration. Liver regeneration is a...
-
Island Grafts: A Model for Studying Skin Regeneration in Isolation from other Processes
This chapter introduces the concept of an island graft, in which large full-thickness skin wounds are created with a small treatment area in the...
-
Spinal Cord Regeneration
Repairing the damaged spinal cord has for a long time eluded neuroscientists. Few other achievements in neuroscience would have such a tremendous...
-
Gastrointestinal parasites of Wolffsohn’s viscacha (Chinchillidae: Lagidium wolffsohni), an endemic rodent species from the wild Patagonia
Parasites are ubiquitous in wildlife populations and have a profound impact on population dynamics. Interest in parasites of wildlife has increased...
-
Assessing seropositivity of MMR antibodies in individuals aged 2–22: evaluating routine vaccination effectiveness after the 2003 mass campaign-a study from Iran’s National Measles Laboratory
Background and purposeThe seroprevalence of antibodies against measles, mumps, and rubella (MMR) was evaluated 17 years following a mass vaccination...
-
Orchestration of antiviral responses within the infected central nervous system
Many newly emerging and re-emerging viruses have neuroinvasive potential, underscoring viral encephalitis as a global research priority. Upon entry...
-
Identification of a novel member of the genus Laulavirus (family Phenuiviridae) from the entomopathogenic ascomycete fungus Cordyceps javanica
The virus family Phenuiviridae (order Hareavirales , comprising segmented negative-sense single stranded RNA viruses) has highly diverse members that...
-
Antimicrobial susceptibility profile of ceftolozane/tazobactam, ceftazidime/avibactam and cefiderocol against carbapenem-resistant Pseudomonas aeruginosa clinical isolates from Türkiye
PurposeCarbapenem resistant Pseudomonas aeruginosa (CR-PA) is escalating worldwide and leaves clinicians few therapeutic options in recent years,...
