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Real world treatment outcomes in polypoidal choroidal vasculopathy in a Caucasian population of British ethnicity
PurposeTo assess treatment response of Polypoidal choroidal vasculopathy (PCV) in a Caucasian population of British ethnicity with intravitreal...
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Peptides and Wound Healing: From Monomer to Combination
Peptides are a kind of compounds formed by α-amino acids linked together by peptide bonds, which are also intermediate products of protein...
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A stochastic approach for parameter optimization of feature detection algorithms for non-target screening in mass spectrometry
Feature detection plays a crucial role in non-target screening (NTS), requiring careful selection of algorithm parameters to minimize false positive...
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Progress, applications, and challenges in high-throughput effect-directed analysis for toxicity driver identification — is it time for HT-EDA?
The rapid increase in the production and global use of chemicals and their mixtures has raised concerns about their potential impact on human and...
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Toxicological effect of acetaminophen, metamizole, and nimesulide cocktail on early development of zebrafish
BackgroundSeveral countries’ most incorrectly discarded medicines are acetaminophen (ACM), metamizole (MTZ), and nimesulide (NMS). These xenobiotics...
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Quantitative comparison of bile acid glucuronides sub-metabolome between intrahepatic cholestasis and healthy pregnant women
Because of the pathological indication and the physiological functions, bile acids (BAs) have occupied the research hotspot in recent decades....
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Anticancer therapeutic potential of multimodal targeting agent- “phosphorylated galactosylated chitosan coated magnetic nanoparticles” against N-nitrosodiethylamine-induced hepatocellular carcinoma
Superparamagnetic iron oxide nanoparticles (SPIONs) are extensively used as carriers in targeted drug delivery and has several advantages in the...
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In Vitro Ciclopirox Glucuronidation in Liver Microsomes from Humans and Various Experimental Animals
Background and ObjectiveCiclopirox is a widely used antifungal drug, redisposition of which has drawn increasing attentions due to multiple promising...
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Treatment of endometriosis with mifepristone mediated by nanostructured lipid carriers
Mifepristone, a progesterone receptor antagonist, was initially used to terminate early pregnancy. As scientific research advanced, it emerged to be...
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Clinical Metagenomic Next-Generation Sequencing for Diagnosis of Central Nervous System Infections: Advances and Challenges
Central nervous system (CNS) infections carry a substantial burden of morbidity and mortality worldwide, and accurate and timely diagnosis is...
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CONUT score as a predictor for anamorelin efficacy in patients with cancer cachexia receiving chemotherapy
BackgroundAnamorelin is expected to improve cancer cachexia by increasing lean body mass (LBM) due to increased appetite and protein synthesis....
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Establishment of a multi-line immunochromatography based on magnetic nanoparticles for simultaneous screening of multiple biomarkers
Biomarkers screening is a benefit approach for early diagnosis of major diseases. In this study, magnetic nanoparticles (MNPs) have been utilized as...
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Welches Potential hat ChatGPT 3.5 für eine qualifizierte Patienteninformation?
IntroductionThe chatbot ChatGPT represents a milestone in the interaction between humans and large databases that are accessible via the internet. It...
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Rapid analysis of untreated food samples by gel loading tip spray ionization mass spectrometry
Rapid, efficient, versatile, easy-to-use, and non-expensive analytical approaches are globally demanded for food analysis. Many ambient ionization...
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Situs inversus partialis (levocardia): an incidental discovery of an extremely rare case during the autopsy of a female with suicidal poisoning
BackgroundSitus inversus is a rare congenital anomaly. In this condition, the abdominal and chest organs are positioned in reverse, a mirror image of...
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Influence of ensitrelvir or nirmatrelvir/ritonavir on tacrolimus clearance in kidney transplant recipients: a single-center case series
BackgroundAmong the oral antivirals used for treating patients with mild-to-moderate novel coronavirus disease 2019 (COVID-19),...
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Increasing Diversity, Equity, Inclusion, and Accessibility in Rare Disease Clinical Trials
Diversity, equity, inclusion, and accessibility (DEIA) are foundational principles for clinical trials and medical research. In rare diseases...
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Identification of Immunodominant Epitopes of Dengue Virus 2 Envelope and NS1 Proteins: Evaluating the Diagnostic Potential of a Synthetic Peptide
Background and ObjectiveDengue is a major infectious disease with potential for outbreaks and epidemics. A specific and sensitive diagnosis is a...
