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Skin graft surgery and its impact on platelet counts in Iranian burn patients: a non-randomized clinical trial
BackgroundPlatelets are critical in maintaining homeostasis and immune response in burn patients. The concentration of platelets decreases in burn...
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Seven-day antibiotic therapy for Enterobacterales bacteremia in high-risk neutropenic patients: toward a new paradigm
PurposeData on short courses of antibiotic therapy for Enterobacterales bacteremia in high-risk neutropenic patients are limited. The aim of the...
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The impact of regional disparities on the availability of meningococcal vaccines in the US
BackgroundIn the United States (US), three types of vaccines are available to prevent invasive meningococcal disease (IMD), a severe and potentially...
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Perioperative complications and cost of posterior decompression with fusion in thoracic spine for ossification of the posterior longitudinal ligament and ossification of the ligamentum flavum -a comparative study using a national inpatient database
BackgroundAlthough posterior decompression with fusion (PDF) are effective for treating thoracic myelopathy, surgical treatment has a high risk of...
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Abnormal platelet parameters in inflammatory bowel disease: a systematic review and meta-analysis
BackgroundPlatelet dysfunction plays a critical role in the pathogenesis of inflammatory bowel disease (IBD). Despite clinical observations...
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Transgender healthcare: metabolic outcomes and cardiovascular risk
Transgender identity is often associated with gender dysphoria and minority stress. Gender-affirming hormone treatment (GAHT) includes masculinising...
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Assessing the relationship between malaria incidence levels and meteorological factors using cluster-integrated regression
This paper introduces a novel approach to modeling malaria incidence in Nigeria by integrating clustering strategies with regression modeling and...
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Profile and Prognostic Impact of Multimorbidity in Elderly Patients with Heart Failure: Are there Differences between Men and Women?
Purpose of ReviewHeart failure (HF) represents a pathology in constant growth, but, despite the fact that a significant proportion of its population...
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Accuracy of oscillometric noninvasive blood pressure at the ankle in the lateral position during general anesthesia
BackgroundThis study aimed to evaluate the accuracy of ankle blood pressure measurements in relation to invasive blood pressure in the lateral...
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G protein-coupled receptor kinases in hypertension: physiology, pathogenesis, and therapeutic targets
G protein-coupled receptors (GPCRs) mediate cellular responses to a myriad of hormones and neurotransmitters that play vital roles in the regulation...
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Development and validation of a scoring system to predict the mortality of hospitalized patients with SARS-CoV-2 Omicron: a nationwide, multicentre study
BackgroundThe Omicron variant broke out in China at the end of 2022, causing a considerable number of severe cases and even deaths. The study aimed...
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Demonstration of Physicochemical and Functional Similarity of Biosimilar Pegfilgrastim-cbqv to Pegfilgrastim
BackgroundPegfilgrastim-cbqv/CHS-1701 (UDENYCA ® ) (hereafter referred to as pegfilgrastim-cbqv) was approved in 2018 by the US Food and Drug...
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Molecular pathway of anticancer effect of next-generation HSP90 inhibitors XL-888 and Debio0932 in neuroblastoma cell line
Neuroblastoma is a common nervous system tumor in childhood, and current treatments are not adequate. HSP90 is a molecular chaperone protein that...
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Primary pulmonary myxoid sarcoma in the interlobar fissure of the left lung lobe: a case report
BackgroundPrimary pulmonary myxoid sarcoma (PPMS) is a rare, low-grade malignant tumor, constituting approximately 0.2% of all lung tumors. Despite...
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Genomic insights into Leminorella grimontii and its chromosomal class A GRI β-lactamase
Leminorella grimontii strain LG-KP-E1-2-T0 was isolated from Zophobas morio larvae. It showed a susceptibility phenotype compatible with the...
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Safe use elements of finished herbal products: insights from consumers and practitioners in Malaysia
BackgroundThe use of finished herbal products (FHPs) among Malaysians today is expanding rapidly leading to a huge market of FHPs in the country....
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Measurement properties of the Regular Physical Exercise Adherence Scale (REPEAS) in individuals with chronic pain
ObjectiveTo examine the measurement properties of the Regular Physical Exercise Adherence Scale (REPEAS) in Brazilians with chronic pain.
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Impact of Race on the Efficacy and Safety of Tofacitinib in Rheumatoid Arthritis: Post Hoc Analysis of Pooled Clinical Trials
IntroductionRacial disparities in disease activity, clinical outcomes, and treatment survival persist despite advancements in rheumatoid arthritis...
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Impact of USMLE Step 1 transition to pass/fail scoring system on medical students’ anxiety, sleep quality, and burnout
IntroductionOriginally designed to evaluate the application of foundational scientific knowledge in clinical contexts, the United States Medical...