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Regulation of IP 3 Receptors by IP 3 and Ca 2+
Inositol 1,4,5-trisphosphate ( IP 3) receptors are intracellular Ca 2+ channels that mediate release of Ca 2+ from intracellular stores. The channels...
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Modeling Calcium Waves
We present an introduction to the mathematics of calcium waves, both intracellular and intercellular. After a discussion of the earlier models I...
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Hormone-Mediated Intercellular Calcium Signalling in an Insect Salivary Gland – Pathways and Mechanisms
The salivary glands of the blowfly Calliphora vicina are a favourable preparation for investigations into spatio-temporal Ca 2+ dynamics in an intact...
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From Simple to Complex Ca 2+ Oscillations: Regulatory Mechanisms and Theoretical Models
Intracellular Ca 2+ oscillations most often appear as regular spikes. However, complex Ca 2+ oscillations in the form of bursting or chaos have also...
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Introduction: Regulatory processes, an emerging feature in intracellular membrane traffic
The subject of this volume is the molecular mechanism of the intracellular membrane trafficking, a central eukaryotic cell biological process. In the...
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Recent Advances in Vinylogous Aldol Reactions and Their Applications in the Syntheses of Natural Products
The synthesis of complex natural products still remains as the bottleneck for the biological evaluation of such compounds. In contrast to the...
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Enantioselective Synthesis of C(8)-Hydroxylated Lignans—Early Approaches and Recent Advances
α-Hydroxylated lignans, dimers of phenylpropene with important biological properties, have been enantioselectively prepared following different...
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Recent Progress in the Total Synthesis of Dolabellane and Dolastane Diterpenes
The isolation, structure and total synthesis of members of four classes of diterpenes has been summarized. Dolabellanes, neodolabellanes, dolastanes...
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Marine Natural Products from Pseudopterogorgia elisabethae: Structures, Biosynthesis, Pharmacology, and Total Synthesis
In the late 1990s, the Caribbean octocoral Pseudopterogorgia elisabethae became the target of extensive chemical investigations leading to the...
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Functions of Rab GTPases in organelle biogenesis
Rab GTPases regulate diverse aspects of the biogenesis of secretory and endocytic organelles. The conformational changes that accompany GTP binding...
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PEGylation of Proteins as Tailored Chemistry for Optimized Bioconjugates
The high potential of peptides and proteins as therapeutic agents has not been fully exploited because of their common shortcomings: the only...
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Polymer Therapeutics for Cancer: Current Status and Future Challenges
Drug delivery systems for cancer therapeutics have revolutionized medicine. Delivery systems have improved the efficacy and reduced the toxicity of...
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Polypeptide and Polypeptide Hybrid Copolymer Synthesis via NCA Polymerization
This article summarizes recent developments in the synthesis of polypeptides and hybrid peptide copolymers. Traditional methods used to polymerize...
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Gene Delivery Using Polymer Therapeutics
The use of polymers as synthetic non-viral carriers for introducing nucleic acids into cells appears very appealing. Polymers can be generated in...
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Nanostructured Devices Based on Block Copolymer Assemblies for Drug Delivery: Designing Structures for Enhanced Drug Function
Block copolymers spontaneously assemble into nanoscaled polymeric micelles, which have significant potential as drug carriers. Following much work...
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Polymer Therapeutics: Polymers as Drugs, Drug and Protein Conjugates and Gene Delivery Systems: Past, Present and Future Opportunities
As the 21st century begins we are witnessing a paradigm shift in medical practice. Whereas the use of polymers in biomedical materials applications...
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Solution Properties of Polypeptide-based Copolymers
The aggregation behaviour of biomimetic polypeptide hybrid copolymers and copolypeptides is here reviewed with a particular eye on the occurrence...
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Biotic and Abiotic Transformation Pathways of Synthetic Musks in the Aquatic Environment
Synthetic musks are being transformed to intermediates or relatively stable metabolites that may exhibit a strong potential for environmental harm....
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Risk Evaluation of Dietary and Dermal Exposure to Musk Fragrances
Synthetic musk compounds comprising nitro musks, polycyclic musks and macrocyclic musks are used in fragrances which are added to a variety of...
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Synthetic Musks in Bioindicators: Monitoring Data of Fish and Human Milk Samples from the Czech Republic
Until the middle of the 1990s, no attention was paid to the pollution of the environment in Czech Republic by synthetic musk fragrances and to the...