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Associations between the choroid plexus and tau in Alzheimer’s disease using an active learning segmentation pipeline
BackgroundThe cerebrospinal fluid (CSF), primarily generated by the choroid plexus (ChP), is the major carrier of the glymphatic system. The...
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The interplay of inflammation and remyelination: rethinking MS treatment with a focus on oligodendrocyte progenitor cells
BackgroundMultiple sclerosis (MS) therapeutic goals have traditionally been dichotomized into two distinct avenues: immune-modulatory-centric...
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Estrogen receptor beta signaling enhances extinction memory recall for heroin-conditioned cues in a sex- and region-specific manner
Return to use, or relapse, is a major challenge in the treatment of opioid use disorder (OUD). Relapse can be precipitated by several factors,...
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Protective defunctioning stoma in bowel segmental resection at the time of total hysterectomy for endometriosis: when less is more
PurposeTo compare postoperative complications in women undergoing total hysterectomy with segmental resection (TH-SR) for intestinal endometriosis...
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Trauma, adversity, and biological aging: behavioral mechanisms relevant to treatment and theory
Although stress and adversity are largely universal experiences, people exposed to greater hardship are at increased risk for negative health...
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Optimization of Total DNA Extraction from Dried Blood Samples
While dried blood spots are a convenient source of genetic material, they are usually associated with a lower DNA yield than from a native sample....
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A systematic strategy for identifying causal single nucleotide polymorphisms and their target genes on Juvenile arthritis risk haplotypes
BackgroundAlthough genome-wide association studies (GWAS) have identified multiple regions conferring genetic risk for juvenile idiopathic arthritis...
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Development and validation of a novel screening tool for deep vein thrombosis in patients with spinal cord injury: A five-year cross-sectional study
Study designCross-sectional study.
ObjectivesDeep vein thrombosis (DVT) presents a significant risk of complication in patients with spinal cord...
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Disruption of neural periodicity predicts clinical response after deep brain stimulation for obsessive-compulsive disorder
Recent advances in surgical neuromodulation have enabled chronic and continuous intracranial monitoring during everyday life. We used this...
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High resolution imaging of human development: shedding light on contrast agents
BackgroundVisualizing (micro)vascular structures remains challenging for researchers and clinicians due to limitations in traditional radiological...
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The positive reinforcing effects of cocaine and opposite-sex social contact: roles of biological sex and estrus
RationalePreclinical studies report that drug use and social contact mutually influence the reinforcing effects of one another. Most of these studies...
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Dual-task improvement of older adults after treadmill walking combined with blood flow restriction of low occlusion pressure: the effect on the heart–brain axis
ObjectiveThis study explored the impact of one session of low-pressure leg blood flow restriction (BFR) during treadmill walking on dual-task...
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Serum Erythropoietin and Ischemic-Modified Albumin Levels in Adolescents with Obsessive–Compulsive Disorder
Erythropoietin (EPO) has neuroprotective effects by increasing oxidative stress resistance and stabilizing redox balance. Ischemic-modified albumin...
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Elevated serum neurofilament light chain levels are associated with hepatic encephalopathy in patients with cirrhosis
Increasing evidences implicate vital role of neuronal damage in the development of hepatic encephalopathy (HE). Neurofilament light chain (NfL) is...
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Complications in spinal cord injury persons with “traditional” colostomy: a case series
IntroductionNeurogenic bowel dysfunction is a frequent consequence of spinal cord injury/disease (SCI/D). A colostomy is considered when conservative...
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Identification of key molecular pathways and genes in BRCA1 and BRCA2-mutant ovarian cancer: evidence from bioinformatics analysis
BRCA1 and BRCA2 mutations significantly increase the risk of breast and ovarian cancers (OC) by affecting crucial cellular processes such as cell...
