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Production and Formulation of Adenovirus Vectors
Adenovirus vectors have attracted considerable interest over the past decade, with ongoing clinical development programs for applications ranging...
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Nonviral Delivery of Cancer Genetic Vaccines
The potential use of genetic vaccines to address numerous diseases including cancer is promising, but currently unrealized. Here, we review...
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Advanced Targeting Strategies for Murine Retroviral and Adeno-associated Viral Vectors
Targeted gene delivery involves broadening viral tropism to infect previously nonpermissive cells, replacing viral tropism to infect a target cell...
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Molecular Conjugates
Molecular conjugates are nanometer-sized entities consisting of synthetic materials (lipids, polycations, targeting agents, and so on) and nucleic...
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Lentiviral Vectors
We review the use of lentiviral vectors in current human gene therapy applications that involve genetic modification of nondividing tissues with...
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Plasmid Vaccines and Therapeutics: From Design to Applications
In the late 1980s, Vical and collaborators discovered that the injection into tissues of unformulated plasmid encoding various proteins resulted in...
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Adeno-associated Virus as a Gene Therapy Vector: Vector Development, Production and Clinical Applications
Adeno-associated virus (AAV) has emerged as an attractive vector for gene therapy. AAV vectors have successfully been utilized to promote...
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Beyond black-box models: explainable AI for embryo ploidy prediction and patient-centric consultation
PurposeTo determine if an explainable artificial intelligence (XAI) model enhances the accuracy and transparency of predicting embryo ploidy status...
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Research Hotspots and Development Trends on Apolipoprotein B in the Field of Atherosclerosis: A Bibliometric Analysis
BackgroundCardiovascular diseases caused by atherosclerosis (AS) are the leading causes of disability and death worldwide. Apolipoprotein B (ApoB),...
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Population Viability and Genetic Structure of the Last Remaining Population of the Critically Endangered Gray Snub-Nosed Monkey (Rhinopithecus brelichi)
Habitat destruction, land conversion, and forest fragmentation over the past several decades have resulted in major declines and local extirpation of...
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Analysis of human papillomavirus type 16 E4, E5 and L2 gene variations among women with cervical infection in **njiang, China
BackgroundThere is a high incidence of cervical cancer in **njiang. Genetic variation in human papillomavirus may increase its ability to invade,...
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Measuring health related quality of life (HRQoL) in Lysosomal Storage Disorders (LSDs): a rapid sco** review of available tools and domains
BackgroundLysosomal storage diseases (LSDs) are a group of rare inherited metabolic disorders, consisting of over 70 diseases that are characterised...
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Quality of life in patients with acromegaly: a sco** review
PurposeTo evaluate the available evidence regarding the quality of life (QoL) in patients with acromegaly, by synthesizing the psychosocial factors...
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Genetic diversity of North African populations in the 17q21 genomic region
The demographic history of human populations in North Africa has been characterized by complex migration processes that have determined the current...
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The chromatin accessibility and transcriptomic landscape of the aging mice cochlea and the identification of potential functional super-enhancers in age-related hearing loss
BackgroundPresbycusis, also referred to as age-related hearing loss (ARHL), is a condition that results from the cumulative effects of aging on an...
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LncRNA BBOX1-AS1 Contributes to Laryngeal Carcinoma Progression by Recruiting SRSF1 to Maintain EFNB2 mRNA Stability
Laryngeal cancer is a common malignancy of the larynx with a generally poor prognosis. This study systematically assessed the functional role of...
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Monitoring of controlled ovarian stimulation in IVF
Since the inception of in vitro fertilization (IVF), monitoring of controlled ovarian stimulation (COS) has traditionally involved numerous...
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Homozygous ACTL9 mutations cause irregular mitochondrial sheath arrangement and abnormal flagellum assembly in spermatozoa and male infertility
PurposeTo identify novel variants in ACTL9 and new phenotypes responsible for male infertility.
MethodsGenomic DNA was extracted from peripheral...
