Search
Search Results
-
Physical enhancement of older adults using hyperbaric oxygen: a randomized controlled trial
IntroductionAging is associated with a progressive decline in the capacity for physical activity. The objective of the current study was to evaluate...
-
Nutrition guidance within a multimodal intervention improves diet quality in prodromal Alzheimer’s disease: Multimodal Preventive Trial for Alzheimer’s Disease (MIND-ADmini)
BackgroundMultimodal lifestyle interventions can benefit overall health, including cognition, in populations at-risk for dementia. However, little is...
-
Aging is associated with sex-specific alteration in the expression of genes encoding for neuroestradiol synthesis and signaling proteins in the mouse trigeminal somatosensory input
Pain perception is influenced by sex and aging, with previous studies indicating the involvement of aromatase, the estradiol synthase enzyme, in...
-
Independent and Joint Associations of Socioeconomic Status and Lifestyle behaviors with Cognitive Impairment among Elderly Chinese Population
BackgroundNumerous studies have shown that there are socioeconomic disparities in people’s health. Health behavior is considered to be an effective...
-
The Causal Relationship between Genetically Predicted Biological Aging, Alzheimer’s Disease and Cognitive Function: A Mendelian Randomisation Study
Aging is one of the most important risk factors for Alzheimer’s disease (AD). Biological aging is a better indicator of the body’s functional state...
-
-
Does clinical practice supported by artificial intelligence improve hypertension care management? A pilot systematic review
Although artificial intelligence (AI) is considered to be a promising tool, evidence for the effectiveness of AI-supported clinical practice for...
-
Free Recall Outperforms Story Recall in Associations with Plasma Biomarkers in Preclinical Alzheimer Disease
BackgroundA decline in episodic memory is one of the earliest cognitive characteristics of Alzheimer disease and memory tests are heavily featured in...
-
Assessing the Benefits and Harms of Pharmacotherapy in Older Adults with Frailty: Insights from Pharmacoepidemiologic Studies of Routine Health Care Data
The objective of this review is to summarize and appraise the research methodology, emerging findings, and future directions in pharmacoepidemiologic...
-
Identification of Differentially Expressed mRNAs and lncRNAs Contributes to Elucidation of Underlying Pathogenesis and Therapeutic Strategy of Recurrent Implantation Failure
Recurrent implantation failure (RIF) is a complex and poorly understood clinical disorder characterized by failure to conceive after repeated embryo...
-
Development of an Endoplasmic Reticulum Stress-Related Diagnostic Signature in Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is a prevalent endocrine and metabolic disorder in premenopausal women. This investigation was to elucidate the...
-
Cognitive reserve modulates mental health in adulthood
Cognitive Reserve (CR) reflects acquired knowledge, skills, and abilities throughout life, and it is known for modulating cognitive efficiency in...
-
Genetic and environmental determinants of bone quality: a cross-sectional analysis of the Hungarian Twin Registry
There is abundant evidence that bone mineral content is highly heritable, while the heritability of bone quality (i.e. trabecular bone score [TBS]...
-
Comparative analysis of the application with the combination of CMA and karyotype in routine and late amniocentesis
PurposeThis is a retrospective comparative study. We aimed to analyze the results of karyotype and chromosomal microarray analysis (CMA) of amniotic...
-
Predicting the Risk of Depression by Migration Status: A Cross-Sectional Study on Older Adults in India
Depression substantially burdens individuals and society due to the associated disease burden, which makes it the fourth most prominent driver of...
-
Exploring the role of microRNAs as diagnostic and prognostic biomarkers in canine mammary tumors
Canine mammary tumors (CMTs) represent a significant health concern in dogs, with a high incidence among intact female dogs. CMTs are a promising...
-
Extended lifespan in female Drosophila melanogaster through late-life calorie restriction
Calorie restriction has many beneficial effects on healthspan and lifespan in a variety of species. However, how late in life application of caloric...
-
Fear Memory in Experimental Models of Parkinson’s Disease
AbstractParkinson’s disease (PD) is a neurodegenerative disease, the main predisposing factor of which is aging. Today, the majority of people...
-
A Statistical Framework for Assessing the Relationship between Biomarkers and Clinical Endpoints in Alzheimer’s Disease
Changes in biomarker levels of Alzheimer’s disease (AD) reflect underlying pathophysiological changes in the brain and can provide evidence of direct...
-
Unveiling Potential Biomarkers in Cerebrospinal Fluid for Amyloid Pathological Positivity in Non-Demented Individuals
BackgroundAlzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-beta (Aβ) plaque accumulation and...
