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Clinical Outcomes and Quality of Life in Children with Central Precocious Puberty: A Pragmatic Analysis
ObjectivesVariable anthropometric and pubertal outcomes are reported in children with central precocious puberty (CPP) based on treatment choices and...
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Stillbirth in women with Type 1 Diabetes mellitus—still a current topic
PurposeCompared to the general stillbirth rate in Germany for term deliveries of 0.12% the risk in type 1 diabetes mellitus is reported to be up to...
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Plasma biomarkers of amyloid, tau, axonal, and neuroinflammation pathologies in dementia with Lewy bodies
BackgroundIncreasing evidence supports the use of plasma biomarkers of amyloid, tau, neurodegeneration, and neuroinflammation for diagnosis of...
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Impaired ATP hydrolysis in blood plasma contributes to age-related neutrophil dysfunction
BackgroundThe function of polymorphonuclear neutrophils (PMNs) decreases with age, which results in infectious and inflammatory complications in...
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Multimorbidity and associated informal care receiving characteristics for US older adults: a latent class analysis
BackgroundOlder adults with varying patterns of multimorbidity may require distinct types of care and rely on informal caregiving to meet their care...
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Maternal Serum Cyclophilin A: A Predictive Biomarker of Preeclampsia in South Indian Women
BackgroundSerum Cyclophilin A (CyPA) is a 20 KD chaperone protein, secreted in response to oxidative stress and has an important role as mediator of...
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Renal denervation: a key approach to hypertension and cardiovascular disease
Sympathetic activation plays a critical role in the development of hypertension and cardiovascular disease, including heart failure and arrhythmias....
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Polygenic risk score for blood pressure and lifestyle factors with overall and CVD mortality: a prospective cohort study in a Japanese population
Although previous polygenic risk score (PRS) studies for cardiovascular disease (CVD) focused on incidence, few studies addressed CVD mortality and...
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Identifying longitudinal cognitive resilience from cross-sectional amyloid, tau, and neurodegeneration
BackgroundLeveraging Alzheimer’s disease (AD) imaging biomarkers and longitudinal cognitive data may allow us to establish evidence of cognitive...
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Metabolic and Inflammatory Profiles Across Infertile PCOS Phenotypes: Implications for Clinical Practice
BackgroundPolycystic ovary syndrome (PCOS) represents a prevalent endocrine disorder affecting women of reproductive age, coupled with an array of...
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Association of frailty with workplace social activity, physical activity, and well-being among older employees: a moderated mediation in two income-variant samples
BackgroundResearch suggests that frailty is associated with lower physical activity and well-being in old age, but social activities at work may...
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Development and Validation of Prediction Model for Neonatal Intensive Care Unit (NICU) Admission Using Machine Learning and Multivariate Statistical Approach
BackgroundThe work aims to provide a method for assessing newborn infants' risk to determine whether they need to be admitted to the NICU before...
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Predictors for the development of motoric cognitive risk syndrome in older adults
BackgroundMotoric cognitive risk (MCR) syndrome refers to a condition where both slow gait and memory complaints coexist, which heightens their...
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Efficacy of GnRH Pulses in Hypogonadism Secondary to Primary Empty Sella: Case Report
This study aims to assess the effectiveness of pulsed gonadotropin-releasing hormone (GnRH) micropump replacement therapy in the treatment of...
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Heat-related illness and dementia: a study integrating epidemiological and experimental evidence
BackgroundHeat-related illness (HRI) is commonly considered an acute condition, and its potential long-term consequences are not well understood. We...
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Physical enhancement of older adults using hyperbaric oxygen: a randomized controlled trial
IntroductionAging is associated with a progressive decline in the capacity for physical activity. The objective of the current study was to evaluate...
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Nutrition guidance within a multimodal intervention improves diet quality in prodromal Alzheimer’s disease: Multimodal Preventive Trial for Alzheimer’s Disease (MIND-ADmini)
BackgroundMultimodal lifestyle interventions can benefit overall health, including cognition, in populations at-risk for dementia. However, little is...
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The use of technology by seniors with neurocognitive disorders in long-term care: a sco** review
BackgroundTo map the current state of knowledge about the use of technology with seniors with neurocognitive disorders in long-term care to foster...
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Choroid plexus volume as a novel candidate neuroimaging marker of the Alzheimer’s continuum
BackgroundEnlarged choroid plexus (ChP) volume has been reported in patients with Alzheimer’s disease (AD) and inversely correlated with cognitive...
