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KLK7 expression in human tumors: a tissue microarray study on 13,447 tumors
BackgroundKallikrein-related peptidase 7 (KLK7) is a chymotrypsin-like serine protease which is essential for the desquamation of corneocytes and...
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Community-Engaged Data Science (CEDS): A Case Study of Working with Communities to Use Data to Inform Change
Data-informed decision making is a critical goal for many community-based public health research initiatives. However, community partners often...
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Clinical Outcomes and Quality of Life in Children with Central Precocious Puberty: A Pragmatic Analysis
ObjectivesVariable anthropometric and pubertal outcomes are reported in children with central precocious puberty (CPP) based on treatment choices and...
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Stillbirth in women with Type 1 Diabetes mellitus—still a current topic
PurposeCompared to the general stillbirth rate in Germany for term deliveries of 0.12% the risk in type 1 diabetes mellitus is reported to be up to...
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Plasma biomarkers of amyloid, tau, axonal, and neuroinflammation pathologies in dementia with Lewy bodies
BackgroundIncreasing evidence supports the use of plasma biomarkers of amyloid, tau, neurodegeneration, and neuroinflammation for diagnosis of...
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Impaired ATP hydrolysis in blood plasma contributes to age-related neutrophil dysfunction
BackgroundThe function of polymorphonuclear neutrophils (PMNs) decreases with age, which results in infectious and inflammatory complications in...
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The metabolic consequences of ‘yo-yo’ dieting are markedly influenced by genetic diversity
BackgroundWeight loss can improve the metabolic complications of obesity. However, it is unclear whether insulin resistance persists despite weight...
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Managing Micronutrient Deficiencies in High-Risk Patients: No Small Feat!
Abstract Purpose of ReviewMicronutrients are vital dietary components for growth and development. Adequate intake of vitamins and minerals through...
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Multimorbidity and associated informal care receiving characteristics for US older adults: a latent class analysis
BackgroundOlder adults with varying patterns of multimorbidity may require distinct types of care and rely on informal caregiving to meet their care...
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Effects of a staff-led multicomponent physical activity intervention on preschooler's fundamental motor skills and physical fitness: The ACTNOW cluster-randomized controlled trial
BackgroundFundamental motor skills (FMS) and physical fitness (FIT) play important roles in child development and provide a foundation for lifelong...
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Associations of activity, sedentary and sleep behaviors with prevalent steatotic liver disease in middle-aged and older adults: the ELSA-Brasil study
BackgroundSteatotic liver disease (SLD) is a prevalent metabolic disease. While single component movement behaviors have been related to its...
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The impact of obesity on chronic oedema/lymphoedema of the leg – an international multicenter cross-sectional study (LIMPRINT)
Background/ObjectivesObesity and chronic oedema/lymphoedema are two distinct but related conditions, rarely investigated together. The aim was to...
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Treatment non-adherence among methadone maintenance patients and associated factors: a multicenter, cross-sectional study in Vietnam
ObjectiveThis multicenter, cross-sectional study was conducted to investigate the prevalence of treatment non-adherence and its associated factors...
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Maternal Serum Cyclophilin A: A Predictive Biomarker of Preeclampsia in South Indian Women
BackgroundSerum Cyclophilin A (CyPA) is a 20 KD chaperone protein, secreted in response to oxidative stress and has an important role as mediator of...
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Metabolic and Inflammatory Profiles Across Infertile PCOS Phenotypes: Implications for Clinical Practice
BackgroundPolycystic ovary syndrome (PCOS) represents a prevalent endocrine disorder affecting women of reproductive age, coupled with an array of...
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Renal denervation: a key approach to hypertension and cardiovascular disease
Sympathetic activation plays a critical role in the development of hypertension and cardiovascular disease, including heart failure and arrhythmias....
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Polygenic risk score for blood pressure and lifestyle factors with overall and CVD mortality: a prospective cohort study in a Japanese population
Although previous polygenic risk score (PRS) studies for cardiovascular disease (CVD) focused on incidence, few studies addressed CVD mortality and...
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Identifying longitudinal cognitive resilience from cross-sectional amyloid, tau, and neurodegeneration
BackgroundLeveraging Alzheimer’s disease (AD) imaging biomarkers and longitudinal cognitive data may allow us to establish evidence of cognitive...
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Association of frailty with workplace social activity, physical activity, and well-being among older employees: a moderated mediation in two income-variant samples
BackgroundResearch suggests that frailty is associated with lower physical activity and well-being in old age, but social activities at work may...
