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Advanced Targeting Strategies for Murine Retroviral and Adeno-associated Viral Vectors
Targeted gene delivery involves broadening viral tropism to infect previously nonpermissive cells, replacing viral tropism to infect a target cell...
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Nonviral Delivery of Cancer Genetic Vaccines
The potential use of genetic vaccines to address numerous diseases including cancer is promising, but currently unrealized. Here, we review...
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Production and Formulation of Adenovirus Vectors
Adenovirus vectors have attracted considerable interest over the past decade, with ongoing clinical development programs for applications ranging...
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Molecular Conjugates
Molecular conjugates are nanometer-sized entities consisting of synthetic materials (lipids, polycations, targeting agents, and so on) and nucleic...
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Lentiviral Vectors
We review the use of lentiviral vectors in current human gene therapy applications that involve genetic modification of nondividing tissues with...
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Plasmid Vaccines and Therapeutics: From Design to Applications
In the late 1980s, Vical and collaborators discovered that the injection into tissues of unformulated plasmid encoding various proteins resulted in...
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Adeno-associated Virus as a Gene Therapy Vector: Vector Development, Production and Clinical Applications
Adeno-associated virus (AAV) has emerged as an attractive vector for gene therapy. AAV vectors have successfully been utilized to promote...
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An integrated clinical approach to children at genetic risk for neurodevelopmental and psychiatric conditions: interdisciplinary collaboration and research infrastructure
BackgroundA sizeable proportion of pathogenic genetic variants identified in young children tested for congenital differences are associated with...
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Germline genome editing of human IVF embryos should not be subject to overly stringent restrictions
This paper critiques the restrictive criteria for germline genome editing recently proposed by Chin, Nguma, and Ahmad in this journal. While praising...
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Is the Homologous Recombination Repair Mutation Defined by a 15-Gene Panel Associated with the Prognosis of Epithelial Ovarian Cancer?
BackgroundThere is no consensus regarding the specific genes included in the homologous recombination repair (HRR) gene panel for identifying the HRR...
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GSTO1 aggravates EGFR-TKIs resistance and tumor metastasis via deglutathionylation of NPM1 in lung adenocarcinoma
Despite significantly improved clinical outcomes in EGFR-mutant lung adenocarcinoma, all patients develop acquired resistance and malignancy on the...
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The Relationship Between GAPDH Gene Polymorphism and Risk of Acute Coronary Syndrome in South Indians with Type 2 Diabetes Mellitus
As glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is one of the regulators of carbonyl stress, a pathogenic mechanism for diabetic complications...
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The Adaptive Role of Bark in the Diet of Budongo Chimpanzees (Pan troglodytes schweinfurthii)
The ingestion of bark has been observed across the animal kingdom and is well documented in free-ranging chimpanzees. Thus far, the best-supported...
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Genetic evidence for causal association between migraine and dementia: a mendelian randomization study
BackgroundThere is an association between migraine and dementia, however, their causal relationship remains unclear. This study employed...
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Incorporating slow NMDA-type receptors with nonlinear voltage-dependent magnesium block in a next generation neural mass model: derivation and dynamics
We derive a next generation neural mass model of a population of quadratic-integrate-and-fire neurons, with slow adaptation, and conductance-based...
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Validation of Nanopore long-read sequencing to resolve RPGR ORF15 genotypes in individuals with X-linked retinitis pigmentosa
X-linked retinitis pigmentosa (XLRP) is characterized by progressive vision loss leading to legal blindness in males and a broad severity spectrum in...
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Saturation genome editing of BAP1 functionally classifies somatic and germline variants
Many variants that we inherit from our parents or acquire de novo or somatically are rare, limiting the precision with which we can associate them...
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Saturation genome editing maps the functional spectrum of pathogenic VHL alleles
To maximize the impact of precision medicine approaches, it is critical to identify genetic variants underlying disease and to accurately quantify...
