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A novel approach to alleviate acetaminophen-induced hepatotoxicity with hybrid balloon flower root-derived exosome-like nanoparticles (BDEs) with silymarin via inhibition of hepatocyte MAPK pathway and apoptosis
IntroductionBalloon flower root-derived exosome-like nanoparticles (BDEs) have recently been proposed as physiologically active molecules with no...
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Activation of kappa opioid receptor suppresses post-traumatic osteoarthritis via sequestering STAT3 on the plasma membrane
ObjectiveKappa opioid receptor (KOR) signaling is involved in joint development and inflammation in Osteoarthritis (OA), while the biochemical...
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Biomechanics of circulating cellular and subcellular bioparticles: beyond separation
Biomechanical attributes have emerged as novel markers, providing a reliable means to characterize cellular and subcellular fractions. Numerous...
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Combined HRAS and NRAS ablation induces a RASopathy phenotype in mice
BackgroundHRAS KO /NRAS KO double knockout mice exhibit exceedingly high rates of perinatal lethality due to respiratory failure caused by a...
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Inhibition of WNT/β-catenin signalling during sex-specific gonadal differentiation is essential for normal human fetal testis development
Sex-specific gonadal differentiation is directed by complex signalling promoting development in either male or female direction, while simultaneously...
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YTHDC1 inhibits autophagy-dependent NF-κB signaling by stabilizing Beclin1 mRNA in macrophages
BackgroundYTHDC1, a key m(6)A nuclear reader, plays a crucial role in regulating mRNA splicing, export, and stability. However, the functional...
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The immune factors have complex causal regulation effects on kidney stone disease: a mendelian randomization study
PurposePrevious studies have reported the potential impact of immune cells on kidney stone disease (KSD), but definitive causal relationships have...
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CRISPR/Cas9 gene editing: a novel strategy for fighting drug resistance in respiratory disorders
Respiratory disorders are among the conditions that affect the respiratory system. The healthcare sector faces challenges due to the emergence of...
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Mitochondrial DNA release via the mitochondrial permeability transition pore activates the cGAS-STING pathway, exacerbating inflammation in acute Kawasaki disease
BackgroundKawasaki disease (KD) is an immune vasculitis of unknown origin, characterized by transient inflammation. The activation of the cGAS-STING...
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BI-2865, a pan-KRAS inhibitor, reverses the P-glycoprotein induced multidrug resistance in vitro and in vivo
BackgroundMultidrug resistance (MDR) limits successful cancer chemotherapy. P-glycoprotein (P-gp), BCRP and MRP1 are the key triggers of MDR....
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KRAS-mutant non-small cell lung cancer (NSCLC) therapy based on tepotinib and omeprazole combination
BackgroundKRAS- mutant non-small cell lung cancer (NSCLC) shows a relatively low response rate to chemotherapy, immunotherapy and KRAS -G12C selective...
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Podoplanin depletion in tonsil-derived mesenchymal stem cells induces cellular senescence via regulation of the p16Ink4a/Rb pathway
BackgroundMesenchymal stem cells (MSCs) are widely used in the development of therapeutic tools in regenerative medicine. However, their quality...
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Therapeutic potential of exosomes derived from mesenchymal stem cells for treatment of systemic lupus erythematosus
Autoimmune diseases are caused by an imbalance in the immune system, producing autoantibodies that cause inflammation leading to tissue damage and...
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Motor skill learning modulates striatal extracellular vesicles’ content in a mouse model of Huntington’s disease
Huntington’s disease (HD) is a neurological disorder caused by a CAG expansion in the Huntingtin gene ( HTT ). HD pathology mostly affects striatal...
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Targeting mTOR signaling pathways in multiple myeloma: biology and implication for therapy
Multiple Myeloma (MM), a cancer of terminally differentiated plasma cells, is the second most prevalent hematological malignancy and is incurable due...
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Downregulation of the metalloproteinases ADAM10 or ADAM17 promotes osteoclast differentiation
Bone resorption is driven through osteoclast differentiation by macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor...
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Circadian patterns of growth factor receptor-dependent signaling and implications for carcinogenesis
Several different signaling pathways that regulate cell proliferation and differentiation are initiated by binding of ligands to cell-surface and...
