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Checkpoint and Coordinated Cellular Responses to DNA Damage
The DNA damage and replication checkpoints are signaling mechanisms that regulate and coordinate cellular responses to genotoxic conditions. The...
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Regulation of S Phase
Regulation of DNA replication is critical for accurate and timely dissemination of genomic material to daughter cells. The cell uses a variety of...
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Control of Cell Proliferation and Growth by Myc Proteins
Myc proteins act as signal transducers that alter cell proliferation in dependence on signals from the extracellular environment. In normal cells,...
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The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis
Since its discovery in 1986, as the first tumor suppressor gene, the retinoblastoma gene (Rb) has been extensively studied. Numerous biochemical and...
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Senescence and Cell Cycle Control
In response to various stresses, such as telomere shortening during continuous proliferation, oxidative stress, DNA damage and aberrant oncogene...
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Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions
The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial...
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G1 Phase: Components, Conundrums, Context
A eukaryotic cell must coordinate DNA synthesis and chromosomal segregation to generate a faithful replica of itself. These events are confined to...
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The ubiquitin-proteasome pathway in cell cycle control
Ubiquitin-mediated proteolysis is one of the key mechanisms underlying cell cycle control. The removal of barriers posed by accumulation of...
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Protein Kinases Involved in Mitotic Spindle Checkpoint Regulation
A number of checkpoint controls function to preserve the genome by restraining cell cycle progression until prerequisite events have been properly...
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Mouse Models of Cell Cycle Regulators: New Paradigms
In yeast, a single cyclin-dependent kinase (Cdk) is able to regulate diverse cell cycle transitions (S and M phases) by associating with multiple...
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In situ analysis of neuronal injury and neuroinflammation during HIV-1 infection
BackgroundSince the introduction of combination antiretroviral therapy (cART) the brain has become an important human immunodeficiency virus (HIV)...
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From balance to imbalance: disruption of plasma glutathione concentration in micropapillary thyroid carcinoma
BackgroundDespite the presence of evidence that establishes a strong correlation between oxidative stress and thyroid cancer, there exists a scarcity...
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Modeling Cell Cycle Control and Cancer with pRB Tumor Suppressor
Cancer is a complex syndrome of diseases characterized by the increased abundance of cells that disrupts the normal tissue architecture within...
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The Centrosome Cycle
Centrosomes are dynamic organelles involved in many aspects of cell function and growth. Centrosomes act as microtubule organizing centers, and...
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Cell Cycle Regulation in Mammalian Germ Cells
Meiosis is a unique form of cellular division by which a diploid cell produces genetically distinct haploid gametes. Initiation and regulation of...
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Clinical efficacy and identification of factors confer resistance to afatinib (tyrosine kinase inhibitor) in EGFR-overexpressing esophageal squamous cell carcinoma
Epidermal growth factor receptor (EGFR) is reportedly overexpressed in most esophageal squamous cell carcinoma (ESCC) patients, but anti-EGFR...
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The limits of fair medical imaging AI in real-world generalization
As artificial intelligence (AI) rapidly approaches human-level performance in medical imaging, it is crucial that it does not exacerbate or propagate...
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NFIC mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to represses malignant phenotype of non-small cell lung cancer cells
BackgroundMultiple genetic and epigenetic regulatory mechanisms are crucial in the development and tumorigenesis process. Transcriptional regulation...
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Cabozantinib and nivolumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial
Supplementation with CBM588, a bifidogenic live bacterial product, has been associated with improved clinical outcomes in persons with metastatic...
