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Modeling Calcium Waves
We present an introduction to the mathematics of calcium waves, both intracellular and intercellular. After a discussion of the earlier models I...
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Regulation of IP 3 Receptors by IP 3 and Ca 2+
Inositol 1,4,5-trisphosphate ( IP 3) receptors are intracellular Ca 2+ channels that mediate release of Ca 2+ from intracellular stores. The channels...
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Hormone-Mediated Intercellular Calcium Signalling in an Insect Salivary Gland – Pathways and Mechanisms
The salivary glands of the blowfly Calliphora vicina are a favourable preparation for investigations into spatio-temporal Ca 2+ dynamics in an intact...
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From Simple to Complex Ca 2+ Oscillations: Regulatory Mechanisms and Theoretical Models
Intracellular Ca 2+ oscillations most often appear as regular spikes. However, complex Ca 2+ oscillations in the form of bursting or chaos have also...
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Checkpoint and Coordinated Cellular Responses to DNA Damage
The DNA damage and replication checkpoints are signaling mechanisms that regulate and coordinate cellular responses to genotoxic conditions. The...
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Regulation of S Phase
Regulation of DNA replication is critical for accurate and timely dissemination of genomic material to daughter cells. The cell uses a variety of...
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Functions of Rab GTPases in organelle biogenesis
Rab GTPases regulate diverse aspects of the biogenesis of secretory and endocytic organelles. The conformational changes that accompany GTP binding...
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Introduction: Regulatory processes, an emerging feature in intracellular membrane traffic
The subject of this volume is the molecular mechanism of the intracellular membrane trafficking, a central eukaryotic cell biological process. In the...
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Control of Cell Proliferation and Growth by Myc Proteins
Myc proteins act as signal transducers that alter cell proliferation in dependence on signals from the extracellular environment. In normal cells,...
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The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis
Since its discovery in 1986, as the first tumor suppressor gene, the retinoblastoma gene (Rb) has been extensively studied. Numerous biochemical and...
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Senescence and Cell Cycle Control
In response to various stresses, such as telomere shortening during continuous proliferation, oxidative stress, DNA damage and aberrant oncogene...
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Risk Evaluation of Dietary and Dermal Exposure to Musk Fragrances
Synthetic musk compounds comprising nitro musks, polycyclic musks and macrocyclic musks are used in fragrances which are added to a variety of...
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Synthetic Musks in Bioindicators: Monitoring Data of Fish and Human Milk Samples from the Czech Republic
Until the middle of the 1990s, no attention was paid to the pollution of the environment in Czech Republic by synthetic musk fragrances and to the...
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Synthetic Musks in Suspended Particulate Matter (SPM), Sediment, and Sewage Sludge
Nitro musk and polycyclic musk fragrances accumulate in solid matters of the aquatic environment. They are analyzed by extraction with an organic...
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Enantioselective Analysis of Polycyclic Musks as a Versatile Tool for the Understanding of Environmental Processes
In this chapter the application of enantioselective chromatography to process studies related to the microbial, enzymatic and photochemical...
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Biotic and Abiotic Transformation Pathways of Synthetic Musks in the Aquatic Environment
Synthetic musks are being transformed to intermediates or relatively stable metabolites that may exhibit a strong potential for environmental harm....
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Mouse Models of Cell Cycle Regulators: New Paradigms
In yeast, a single cyclin-dependent kinase (Cdk) is able to regulate diverse cell cycle transitions (S and M phases) by associating with multiple...
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G1 Phase: Components, Conundrums, Context
A eukaryotic cell must coordinate DNA synthesis and chromosomal segregation to generate a faithful replica of itself. These events are confined to...
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The ubiquitin-proteasome pathway in cell cycle control
Ubiquitin-mediated proteolysis is one of the key mechanisms underlying cell cycle control. The removal of barriers posed by accumulation of...
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Protein Kinases Involved in Mitotic Spindle Checkpoint Regulation
A number of checkpoint controls function to preserve the genome by restraining cell cycle progression until prerequisite events have been properly...