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The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis
Since its discovery in 1986, as the first tumor suppressor gene, the retinoblastoma gene (Rb) has been extensively studied. Numerous biochemical and...
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Senescence and Cell Cycle Control
In response to various stresses, such as telomere shortening during continuous proliferation, oxidative stress, DNA damage and aberrant oncogene...
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Control of Cell Proliferation and Growth by Myc Proteins
Myc proteins act as signal transducers that alter cell proliferation in dependence on signals from the extracellular environment. In normal cells,...
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Development of Technetium-99m and Rhenium-188 Radiopharmaceuticals Containing a Terminal Metal–Nitrido Multiple Bond for Diagnosis and Therapy
The chemistry of nitrido complexes of technetium has played an important role in the search of new Tc-99m radiopharmaceuticals and in providing...
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Checkpoint and Coordinated Cellular Responses to DNA Damage
The DNA damage and replication checkpoints are signaling mechanisms that regulate and coordinate cellular responses to genotoxic conditions. The...
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Monitoring Multidrug Resistance P-Glycoprotein Drug Transport Activity with Single-Photon Emission Computed Tomography and Positron Emission Tomography Radiopharmaceuticals
Multidrug resistance (MDR) mediated by overexpression of MDR1 P-glycoprotein (Pgp) is one of the best characterized transporter-mediated barriers to...
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Regulation of S Phase
Regulation of DNA replication is critical for accurate and timely dissemination of genomic material to daughter cells. The cell uses a variety of...
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Mouse Models of Cell Cycle Regulators: New Paradigms
In yeast, a single cyclin-dependent kinase (Cdk) is able to regulate diverse cell cycle transitions (S and M phases) by associating with multiple...
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Radiopharmaceuticals for Positron Emission Tomography Imaging of Somatostatin Receptor Positive Tumors
The targeting of somatostatin receptors in tumors has been a goal in cancer treatment and diagnosis since the 1980s. Over the past two decades, great...
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G1 Phase: Components, Conundrums, Context
A eukaryotic cell must coordinate DNA synthesis and chromosomal segregation to generate a faithful replica of itself. These events are confined to...
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The ubiquitin-proteasome pathway in cell cycle control
Ubiquitin-mediated proteolysis is one of the key mechanisms underlying cell cycle control. The removal of barriers posed by accumulation of...
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Protein Kinases Involved in Mitotic Spindle Checkpoint Regulation
A number of checkpoint controls function to preserve the genome by restraining cell cycle progression until prerequisite events have been properly...
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Rhenium and Technetium Complexes Anchored by Phosphines and Scorpionates for Radiopharmaceutical Applications
This review presents a comprehensive overview of the most significant developments in the chemistry of technetium and rhenium complexes anchored by...
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The Centrosome Cycle
Centrosomes are dynamic organelles involved in many aspects of cell function and growth. Centrosomes act as microtubule organizing centers, and...
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Cell Cycle Regulation in Mammalian Germ Cells
Meiosis is a unique form of cellular division by which a diploid cell produces genetically distinct haploid gametes. Initiation and regulation of...
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Radiolabeled Integrin αvβ3 Antagonists as Radiopharmaceuticals for Tumor Radiotherapy
Integrins are a family of proteins that facilitate cellular adhesion to and migration on the extracellular matrix proteins found in intercellular...
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Modeling Cell Cycle Control and Cancer with pRB Tumor Suppressor
Cancer is a complex syndrome of diseases characterized by the increased abundance of cells that disrupts the normal tissue architecture within...
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6-Hydrazinonicotinamide Derivatives as Bifunctional Coupling Agents for 99mTc-Labeling of Small Biomolecules
99mTc-labeled small biomolecules are a class of receptor-based, target specific radiopharmaceuticals for the detection of various diseases, such as...
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New Organometallic Technetium Complexes for Radiopharmaceutical Imaging
It is the objective of this review to introduce the reader to the current status of organometallic chemistry, oriented towards the development of...
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Image quality of whole-body diffusion MR images comparing deep-learning accelerated and conventional sequences
ObjectivesTo compare the image quality of deep learning accelerated whole-body (WB) with conventional diffusion sequences.
MethodsFifty consecutive...
