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  1. G1 Phase: Components, Conundrums, Context

    A eukaryotic cell must coordinate DNA synthesis and chromosomal segregation to generate a faithful replica of itself. These events are confined to...
    Stephanie J. Moeller, Robert J. Sheaff in Cell Cycle Regulation
    Chapter
  2. The ubiquitin-proteasome pathway in cell cycle control

    Ubiquitin-mediated proteolysis is one of the key mechanisms underlying cell cycle control. The removal of barriers posed by accumulation of...
    Steven I. Reed in Cell Cycle Regulation
    Chapter
  3. Protein Kinases Involved in Mitotic Spindle Checkpoint Regulation

    A number of checkpoint controls function to preserve the genome by restraining cell cycle progression until prerequisite events have been properly...
    Ingrid Hoffmann in Cell Cycle Regulation
    Chapter
  4. Loss of sheen in Oguchi disease following short wavelength exposure

    Haseeb N. Akhtar, Luke Nicholson, ... Omar A. Mahroo in Eye
    Article Open access 14 July 2024
  5. Outcomes of patients undergoing third hematopoietic cell transplantation for hematologic malignancies

    With advancements in novel therapeutics, it is unclear whether third hematopoietic cell transplantation (HCT3) has a place in the treatment of...

    Emily R. Cox, Corinne Summers, ... Monica S. Thakar in Annals of Hematology
    Article 14 July 2024
  6. Multimedia Medical Informatics System in Healthcare

    In our modern 21st century, daily life would be unthinkable without computers. Multimedia and virtual reality are useful for people with spein...
    Chapter
  7. The Centrosome Cycle

    Centrosomes are dynamic organelles involved in many aspects of cell function and growth. Centrosomes act as microtubule organizing centers, and...
    Christopher P. Mattison, Mark Winey in Cell Cycle Regulation
    Chapter
  8. Modeling Cell Cycle Control and Cancer with pRB Tumor Suppressor

    Cancer is a complex syndrome of diseases characterized by the increased abundance of cells that disrupts the normal tissue architecture within...
    Lili Yamasaki in Cell Cycle Regulation
    Chapter
  9. Self-Assembling Nanopeptides Become a New Type of Biomaterial

    Combining physics, engineering, chemistry and biology, we can now design, synthesize and fabricate biological nano-materials at the molecular...
    **aojun Zhao, Shuguang Zhang in Polymers for Regenerative Medicine
    Chapter
  10. Modulating Extracellular Matrix at Interfaces of Polymeric Materials

    As extracellular matrices (ECM) closely interact with cells in living tissues and, through this, influence essentially any aspect of life...
    Carsten Werner, Tilo Pompe, Katrin Salchert in Polymers for Regenerative Medicine
    Chapter
  11. Cell Cycle Regulation in Mammalian Germ Cells

    Meiosis is a unique form of cellular division by which a diploid cell produces genetically distinct haploid gametes. Initiation and regulation of...
    Changanamkandath Rajesh, Douglas L. Pittman in Cell Cycle Regulation
    Chapter
  12. Altered RNA export by SF3B1 mutants confers sensitivity to nuclear export inhibition

    SF3B1 mutations frequently occur in cancer yet lack targeted therapies. Clinical trials of XPO1 inhibitors, selinexor and eltanexor, in high-risk...

    Sana Chaudhry, Felipe Beckedorff, ... Justin Taylor in Leukemia
    Article Open access 13 July 2024
  13. PET imaging of neuroinflammation: any credible alternatives to TSPO yet?

    Over the last decades, the role of neuroinflammation in neuropsychiatric conditions has attracted an exponentially growing interest. A key driver for...

    Fabien Chauveau, Alexandra Winkeler, ... Guillaume Becker in Molecular Psychiatry
    Article 13 July 2024
  14. Doing a double take: when transthoracic echocardiography fails for mitral valve annuloplasty ring endocarditis with Streptococcus pyogenes: a case report

    Background

    This case highlights several complications of a late and rare presentation of culture-negative Streptococcus pyogenes endocarditis of a...

    Jonathan K. Schilling, Robert Tungate, ... Antonio H. Frangieh in Journal of Medical Case Reports
    Article Open access 13 July 2024
  15. Effectiveness of synthetic versus autologous bone grafts in foot and ankle surgery: a systematic review and meta-analysis

    Background

    All orthopaedic procedures, comprising foot and ankle surgeries, seemed to show a positive trend, recently. Bone grafts are commonly...

    Amir Human Hoveidaei, Amirhossein Ghaseminejad-Raeini, ... Janet D. Conway in BMC Musculoskeletal Disorders
    Article Open access 13 July 2024
  16. Dietary salt promotes cognitive impairment through repression of SIRT3/PINK1-mediated mitophagy and fission

    Dietary salt is increasingly recognized as an independent risk factor for cognitive impairment. However, the exact mechanisms are not yet fully...

    Haixia Fan, Minghao Yuan, ... Zhiyou Cai in Molecular and Cellular Biochemistry
    Article 13 July 2024
  17. Analysis of Oncology and Radiation Therapy Representation on the National Board of Medical Examiners Official Practice Material for the United States National Standardized Medical Board Examinations

    Radiation therapy (RT) is a critical component of multidisciplinary cancer care, but has inconsistent curricular exposure. We characterize the...

    Mary T. Mahoney, Lauren C. Linkowski, ... Malcolm D. Mattes in Journal of Cancer Education
    Article Open access 13 July 2024
  18. Inhibitors of apolipoprotein C3, triglyceride levels, and risk of pancreatitis: a systematic review and meta-analysis

    In recent years, novel apoC3 inhibitor therapies for the treatment of hypertriglyceridemia have been developed and assessed through phase II and III...

    Walter Masson, Martín Lobo, ... Daniel Siniawski in Reviews in Endocrine and Metabolic Disorders
    Article 13 July 2024
  19. Emerging biologic augmentation strategies for meniscal repair: a systematic review

    Background

    Meniscal repair should be the gold standard. However, the meniscus is poorly vascularized and even an excellent meniscus repair may not...

    David Mazy, Jessica Wang, ... Marie-Lyne Nault in BMC Musculoskeletal Disorders
    Article Open access 13 July 2024
  20. Impact and effect of imaging referral guidelines on patients and radiology services: a systematic review

    Objectives

    The objective of this systematic review was to offer a comprehensive overview and explore the associated outcomes from imaging referral...

    Yi **ang Tay, Shane Foley, ... Jonathan P. McNulty in European Radiology
    Article Open access 13 July 2024
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