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DDS–SIRC Cooperative Conferences Feel the Burn: RFA for Chronic Radiation Proctitis
Chronic radiation proctitis, although relatively rare, can be the source of severe comorbidity in patients who had undergone prior radiotherapy for...
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Transverse versus longitudinal mucosal incision during POEM for esophageal motility disorders: a randomized trial
BackgroundLongitudinal incision is the commonly used incision for entry into the submucosal space during peroral endoscopic myotomy (POEM) for...
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What does “urgency” mean when prioritizing cancer treatment? Results from a qualitative study with German oncologists and other experts during the COVID-19 pandemic
PurposeCancer care in Germany during the COVID-19 pandemic was affected by resource scarcity and the necessity to prioritize medical measures. This...
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Safety and efficacy of robotic anti-reflux surgery in geriatric patients: a comparative analysis
IntroductionAs our population ages, older adults are being considered for anti-reflux surgery (ARS). Geriatric patients typically have heightened...
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Laparoscopic caudate lobe resections: How I do it: tips and pitfalls (with video)
BackgroundThe caudate lobe (S1) of the liver, due to its deep central position, presents a formidable challenge for laparoscopic resection....
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LapBot-Safe Chole: validation of an artificial intelligence-powered mobile game app to teach safe cholecystectomy
BackgroundGaming can serve as an educational tool to allow trainees to practice surgical decision-making in a low-stakes environment. LapBot is a...
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Resveratrol-based nano-formulations as an emerging therapeutic strategy for ovarian carcinoma: autophagy stimulation and SIRT-1/Beclin/MMP-9/P53/AKT signaling
BackgroundResveratrol (RVS) is a stilbene derivative polyphenolic compound extensively recognized for its anti-inflammatory, antioxidant and...
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Consumer wearable devices for evaluation of heart rate control using digoxin versus beta-blockers: the RATE-AF randomized trial
Consumer-grade wearable technology has the potential to support clinical research and patient management. Here, we report results from the RATE-AF...
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Efficacy of chemotherapy plus immune checkpoint inhibitors in patients with non-small cell lung cancer who have rare oncogenic driver mutations: a retrospective analysis
BackgroundTargeted therapy is now the standard of care in driver–oncogene-positive non-small cell lung cancer (NSCLC). Its initial clinical effects...
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Epithelial to Mesenchymal Transition in Neuroblastoma: Mechanisms and Therapeutic Considerations
Purpose of ReviewNeuroblastoma (NB) is a solid tumour of the extracranial region in children, and it originates from the develo** sympathetic...
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Ferroptosis crosstalk in anti-tumor immunotherapy: molecular mechanisms, tumor microenvironment, application prospects
Immunotherapies for cancer, specifically immune checkpoint inhibition (ICI), have shown potential in reactivating the body’s immune response against...
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Food security among black breast cancer survivors in Maryland: insights from an online pilot study
PurposeFood security, and reliable access to nutritious food, is essential for maintaining health yet remains elusive for many, including U.S....
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Implementing a no-drain policy for extraperitoneal colorectal anastomosis in a real-life setting: analysis of outcomes and surgeons’ adherence
AimRecent evidence has questioned the usefulness of anastomotic drain (AD) after low anterior resection (LAR). However, the implementation and...
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PRRX1-OLR1 axis supports CAFs-mediated lung cancer progression and immune suppression
ObjectiveTo investigate the mechanism by which cancer-associated fibroblasts (CAFs) affect the growth and immune evasion of lung cancer cells.
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Quantitative and qualitative evaluation of high-quality hepatobiliary phase imaging with shortened timing and utility in patients with compromised liver function
PurposeTo compare high flip angle (FA) hepatobiliary-phase (hHBP) imaging with variable time intervals to conventional HBP (cHBP) to assess the...
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Granulocyte colony-stimulating factor has the potential to attenuate the therapeutic efficacy of chemo-immunotherapy for extensive-stage small-cell lung cancer
BackgroundGranulocyte colony-stimulating factor (G-CSF) has the potential to attenuate the anti-tumor immune responses of T-cells by increasing...
