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Efficacy of MAGE-A4 long peptide as a universal immunoprevention cancer vaccine
BackgroundThe clinical application of peptide vaccines in tumor immunotherapy holds significant promise. Peptide-based tumor vaccines are currently...
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Semaphorin 3C (Sema3C) reshapes stromal microenvironment to promote hepatocellular carcinoma progression
More than 90% of hepatocellular carcinoma (HCC) cases develop in the presence of fibrosis or cirrhosis, making the tumor microenvironment (TME) of...
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Building genomic capacity for precision health in Africa
The African continent is poised to have a pivotal role in the global population landscape, with the United Nations projecting a population of 2.5...
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Sex-dependent APOE4 neutrophil–microglia interactions drive cognitive impairment in Alzheimer’s disease
APOE4 is the strongest genetic risk factor for Alzheimer’s disease (AD), with increased odds ratios in female carriers. Targeting amyloid plaques...
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Targeting specific DNA G-quadruplexes with CRISPR-guided G-quadruplex-binding proteins and ligands
Despite the demonstrated importance of DNA G-quadruplexes (G4s) in health and disease, technologies to readily manipulate specific G4 folding for...
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Adult acute leukemia patients with gram-negative bacteria bloodstream infection: Risk factors and outcomes of antibiotic-resistant bacteria
This study aims to analyze the risk factors for the development of multidrug-resistant (MDR) and carbapenem-resistant (CR) bacteria bloodstream...
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Preparation, optimization, and characterization of genistein-ginseng long-acting polymeric gel as a breast cancer treatment alternative
To address the prevalent genistein (GST) metabolism and inadequate intestinal absorption, an oral long-acting and gastric in-situ gelling gel was...
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Comparison of Outcomes in Bowel Resections by Gynecologic Oncologists Versus General Surgeons During Maximal Cytoreductive Surgery for Advanced Ovarian Cancer: Gynecologic Oncology Research Investigators Collaboration Study (GORILLA-3006)
BackgroundThis report describes the oncologic outcomes for patients with advanced ovarian cancer who had bowel surgery performed by gynecologic...
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Impact of antiphospholipid antibodies on cardiac valve lesions in systemic lupus erythematosus: a systematic review and meta-analysis
This meta-analysis assesses antiphospholipid antibodies’ (aPLs) impact on heart valve disease in Systemic Lupus Erythematosus (SLE) patients. We...
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Identification of purinergic system components in the venom of Bothrops mattogrossensis and the inhibitory effect of specioside extracted from Tabebuia aurea
Snake bites are a severe problem in the countryside of Brazil and are usually attributed to snakes of the genera Bothrops, Crotalus , and Lachesis ....
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Treatment Strategies for Filamentous Fungi Keratitis
IntroductionThis research aims to describe clinical findings, epidemiology and treatment outcomes in patients with filamentous fungi keratitis of a...
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Effect of Opioid-Free General Anesthesia Versus Opioid-Based General Anesthesia on Postoperative Pain and Immune Response in Patients Undergoing Breast Cancer Surgery: A Randomized Controlled Trial
Perioperative opioids are associated with several adverse effects including nausea, vomiting, and long-term addiction. Opioid-free anesthesia may...
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Small molecule tyrosine kinase inhibitors approved for systemic therapy of advanced hepatocellular carcinoma: recent advances and future perspectives
Liver cancer is the sixth most commonly diagnosed cancer and the third leading cause of cancer death in the world, and hepatocellular carcinoma (HCC)...
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Bibliometric and visual analysis in the field of two-dimensions nano black phosphorus in cancer from 2015 to 2023
This study aims to provide a comprehensive summary of the status and trends of Two-Dimensional Nano Black Phosphorus (2D nano BP) in cancer research...
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Cross-sectional study of hepatitis B virus infection in female breast cancer patients in China for the first time diagnosed
BackgroundThe correlation between breast cancer and hepatitis B virus (HBV) remains inconclusive. This study aims to explore the serological status...
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Genomic characterization of Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) strains circulating in three university hospitals in Northern Italy over three years
ObjectivesGenomic surveillance of Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) is crucial for virulence,...
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Managing Micronutrient Deficiencies in High-Risk Patients: No Small Feat!
Abstract Purpose of ReviewMicronutrients are vital dietary components for growth and development. Adequate intake of vitamins and minerals through...
