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1. Lentiviral Vectors

   We review the use of lentiviral vectors in current human gene therapy applications that involve genetic modification of nondividing tissues with...

   Nils Loewen, Eric M. Poeschla in Gene Therapy and Gene Delivery Systems

   Chapter
   

2. Self-Assembling Nanopeptides Become a New Type of Biomaterial

   Combining physics, engineering, chemistry and biology, we can now design, synthesize and fabricate biological nano-materials at the molecular...

   **aojun Zhao, Shuguang Zhang in Polymers for Regenerative Medicine

   Chapter
   

3. Modulating Extracellular Matrix at Interfaces of Polymeric Materials

   As extracellular matrices (ECM) closely interact with cells in living tissues and, through this, influence essentially any aspect of life...

   Carsten Werner, Tilo Pompe, Katrin Salchert in Polymers for Regenerative Medicine

   Chapter
   

4. Plasmid Vaccines and Therapeutics: From Design to Applications

   In the late 1980s, Vical and collaborators discovered that the injection into tissues of unformulated plasmid encoding various proteins resulted in...

   Marston Manthorpe, Peter Hobart, ... Alain Rolland in Gene Therapy and Gene Delivery Systems

   Chapter
   

5. Adeno-associated Virus as a Gene Therapy Vector: Vector Development, Production and Clinical Applications

   Adeno-associated virus (AAV) has emerged as an attractive vector for gene therapy. AAV vectors have successfully been utilized to promote...

   Joshua C. Grieger, Richard J. Samulski in Gene Therapy and Gene Delivery Systems

   Chapter
   

6. Role of subcytotoxic stress in tissue ageing

   Most commonly stress-induced premature senescence (SIPS) is defined as the long-term effects of subcytotoxic stress on proliferative cell types,...

   Olivier Toussaint, Michel Salmon, ... Florence Chainiaux in Model Systems in Aging

   Chapter
   

7. Mammalian and bird aging, oxygen radicals, and restricted feeding

   In this chapter, the relationship of aging with oxidative stress is reviewed. Endogenous tissue antioxidants do not determine aging because they...

   Gustavo Barja in Model Systems in Aging

   Chapter
   

8. Mitochondria, metabolism, and aging in yeast

   Quantitative and qualitative changes in metabolism take place when the lifespan is extended in yeast either by genetic or nutritional manipulation....

   S. Michal Jazwinski in Model Systems in Aging

   Chapter
   

9. Yeast as a model for ageing and apoptosis research

   Apoptosis is a form of programmed cell death with a crucial role in health and disease in metazoans. Recent findings demonstrate the existence of an...

   Michael Breitenbach, Frank Madeo, ... Alena Pichova in Model Systems in Aging

   Chapter
   

10. Large-Scale Production of Hairy Root

    Many products of interest are synthesized in organized tissues, but not formed in suspension or callus culture. Therefore, most attention has been...

    Nobuyuki Uozumi in Recent Progress of Biochemical and Biomedical Engineering in Japan II

    Chapter
    

11. Enzymatic Synthesis of Structured Lipids

    Structured lipids (SLs) are defined as lipids that are modified chemically or enzymatically in order to change their structure. This review deals...

    Yugo Iwasaki, Tsuneo Yamane in Recent Progress of Biochemical and Biomedical Engineering in Japan I

    Chapter
    

12. Spinal Cord Regeneration

    Repairing the damaged spinal cord has for a long time eluded neuroscientists. Few other achievements in neuroscience would have such a tremendous...

    Poonam Verma, James Fawcett in Regenerative Medicine II

    Chapter
    

13. The function of Sec1/Munc18 proteins – Solution of the mystery in sight?

    Members of the Sec1/Munc18 (SM) protein family form a central part of the machinery responsible for transport vesicle docking and fusion. Their...

    Maria Kauppi, Jussi Jäntti, Vesa M. Olkkonen in Regulatory Mechanisms of Intracellular Membrane Transport

    Chapter
    

14. Phosphoinositides and membrane traffic in health and disease

    The phosphorylated derivatives of phosphatidylinositol (PtdIns) are collectively known as the polyphosphoinositides (PIs) and they were originally...

    Anna Godi, Antonella Di Campli, Maria Antonietta De Matteis in Regulatory Mechanisms of Intracellular Membrane Transport

    Chapter
    

15. Peripheral Nerve Regeneration

    The nerve chamber model has dominated the experimental study of peripheral nerve (PN) regeneration with animal models as well as in several clinical...

    Mei Zhang, Ioannis V. Yannas in Regenerative Medicine II

    Chapter
    

16. Regulating membrane curvature

    Membranes of living cells are subject to a variety of shape changes. Membrane deformation is essential for cell division, locomotion, organelle...

    Joost C.M. Holthuis in Regulatory Mechanisms of Intracellular Membrane Transport

    Chapter
    

17. Effect of annealing temperature on the optoelectrical synapse behaviors of A-ZnO microtube

    Optoelectronic synapses with fast response, low power consumption, and memory function hold great potential in the future of artificial intelligence...

    Yongman Pan, Qiang Wang, ... Yijian Jiang in Discover Nano

    Article Open access 13 July 2024
    

18. Cell-cell contact-dependent secretion of large-extracellular vesicles from EFNB^high cancer cells accelerates peritoneal dissemination

    Background

    Large non-apoptotic vesicles released from the plasma membrane protrusions are classified as large-EVs (LEVs). However, the triggers of LEV...

    Kaito Hayashi, Kurara Takagane, ... Masamitsu Tanaka in British Journal of Cancer

    Article 13 July 2024
    

19. Biophysical characterization of the phase separation of TDP-43 devoid of the C-terminal domain

    Background

    Frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-TDP), amyotrophic lateral sclerosis (ALS) and limbic-predominant...

    Tommaso Staderini, Alessandra Bigi, ... Fabrizio Chiti in Cellular & Molecular Biology Letters

    Article Open access 13 July 2024
    

20. Effect of α7 nAChR-autophagy axis of deciduous tooth pulp stem cells in regulating IL-1β in the process of physiological root resorption of deciduous teeth

    Abstract

    Physiological root resorption of deciduous teeth is a normal phenomenon occurring during the developmental stages of children. Previous...

    Tiankai Di, Yujiang Chen, ... Lulu Wang in Journal of Molecular Medicine

    Article 13 July 2024