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English Biomedicine, general Molecular medicine

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  2. Functions of Rab GTPases in organelle biogenesis

    Rab GTPases regulate diverse aspects of the biogenesis of secretory and endocytic organelles. The conformational changes that accompany GTP binding...
    Christopher G. Burd, Ruth N. Collins in Regulatory Mechanisms of Intracellular Membrane Transport
    Chapter

  3. Introduction: Regulatory processes, an emerging feature in intracellular membrane traffic

    The subject of this volume is the molecular mechanism of the intracellular membrane trafficking, a central eukaryotic cell biological process. In the...
    Sirkka Keränen, Jussi Jäntti in Regulatory Mechanisms of Intracellular Membrane Transport
    Chapter

  4. Advanced Targeting Strategies for Murine Retroviral and Adeno-associated Viral Vectors

    Targeted gene delivery involves broadening viral tropism to infect previously nonpermissive cells, replacing viral tropism to infect a target cell...
    Julie H. Yu, David V. Schaffer in Gene Therapy and Gene Delivery Systems
    Chapter

  5. Nonviral Delivery of Cancer Genetic Vaccines

    The potential use of genetic vaccines to address numerous diseases including cancer is promising, but currently unrealized. Here, we review...
    Steven R. Little, Robert Langer in Gene Therapy and Gene Delivery Systems
    Chapter

  6. Production and Formulation of Adenovirus Vectors

    Adenovirus vectors have attracted considerable interest over the past decade, with ongoing clinical development programs for applications ranging...
    Nedim E. Altaras, John G. Aunins, ... Jayanthi J. Wolf in Gene Therapy and Gene Delivery Systems
    Chapter

  7. Molecular Conjugates

    Molecular conjugates are nanometer-sized entities consisting of synthetic materials (lipids, polycations, targeting agents, and so on) and nucleic...
    Jeremy Heidel, Swaroop Mishra, Mark E. Davis in Gene Therapy and Gene Delivery Systems
    Chapter

  8. Regulation of SNARE assembly by protein phosphorylation

    Protein phosphorylation is emerging as an important regulatory mechanism that controls the secretory pathway. It enables coupling between the...
    Adina Weinberger, Jeffrey E. Gerst in Regulatory Mechanisms of Intracellular Membrane Transport
    Chapter

  9. Molecular mechanisms in clathrin-mediated membrane budding

    Clathrin-coated vesicles (CCVs) form at the plasma membrane where they select cargo for endocytic entry into cells. CCVs also form at the trans-Golgi...
    Brigitte Ritter, Peter S. McPherson in Regulatory Mechanisms of Intracellular Membrane Transport
    Chapter

  10. Tethering proteins in membrane traffic

    In eukaryotic cells, protein secretion and the transport of materials between membrane-bounded organelles require efficient and accurate delivery of...
    Sarah Chu, Wei Guo in Regulatory Mechanisms of Intracellular Membrane Transport
    Chapter

  11. Regulation of exocytotic events by centrosome-analogous structures

    Centrosomes, spindle pole bodies, and related structures, generally termed microtubule organising centres (MTOCs; Pickett-Heaps 1969), are best...
    Christof Taxis, Michael Knop in Regulatory Mechanisms of Intracellular Membrane Transport
    Chapter

  12. Adeno-associated Virus as a Gene Therapy Vector: Vector Development, Production and Clinical Applications

    Adeno-associated virus (AAV) has emerged as an attractive vector for gene therapy. AAV vectors have successfully been utilized to promote...
    Joshua C. Grieger, Richard J. Samulski in Gene Therapy and Gene Delivery Systems
    Chapter

  13. Lentiviral Vectors

    We review the use of lentiviral vectors in current human gene therapy applications that involve genetic modification of nondividing tissues with...
    Nils Loewen, Eric M. Poeschla in Gene Therapy and Gene Delivery Systems
    Chapter

  14. Plasmid Vaccines and Therapeutics: From Design to Applications

    In the late 1980s, Vical and collaborators discovered that the injection into tissues of unformulated plasmid encoding various proteins resulted in...
    Marston Manthorpe, Peter Hobart, ... Alain Rolland in Gene Therapy and Gene Delivery Systems
    Chapter

  15. Regulating membrane curvature

    Membranes of living cells are subject to a variety of shape changes. Membrane deformation is essential for cell division, locomotion, organelle...
    Joost C.M. Holthuis in Regulatory Mechanisms of Intracellular Membrane Transport
    Chapter

  16. Phosphoinositides and membrane traffic in health and disease

    The phosphorylated derivatives of phosphatidylinositol (PtdIns) are collectively known as the polyphosphoinositides (PIs) and they were originally...
    Anna Godi, Antonella Di Campli, Maria Antonietta De Matteis in Regulatory Mechanisms of Intracellular Membrane Transport
    Chapter

  17. The function of Sec1/Munc18 proteins – Solution of the mystery in sight?

    Members of the Sec1/Munc18 (SM) protein family form a central part of the machinery responsible for transport vesicle docking and fusion. Their...
    Maria Kauppi, Jussi Jäntti, Vesa M. Olkkonen in Regulatory Mechanisms of Intracellular Membrane Transport
    Chapter

  18. Breaking barriers: sha** global health futures with pilot and feasibility initiative

    In the dynamic landscape of global health, the journey from a new development to its implementation is often fraught with challenges. Yet, it is...

    Ambreen Nizar, Magdalena Janus in Pilot and Feasibility Studies
    Article Open access 03 July 2024

  19. KLK7 expression in human tumors: a tissue microarray study on 13,447 tumors

    Background

    Kallikrein-related peptidase 7 (KLK7) is a chymotrypsin-like serine protease which is essential for the desquamation of corneocytes and...

    Simon Kind, Carolina Palacios Castillo, ... Frank Jacobsen in BMC Cancer
    Article Open access 03 July 2024

  20. A holistic lifestyle mobile health intervention for the prevention of type 2 diabetes and common mental disorders in Asian women with a history of gestational diabetes: a randomised control trial with 3-year follow-up protocol

    Background

    Women with a history of gestational diabetes mellitus (GDM) are 12-fold more likely to develop type 2 diabetes (T2D) 4–6 years after...

    Alicia Salamanca-Sanabria, Seaw Jia Liew, ... Johan Gunnar Eriksson in Trials
    Article Open access 03 July 2024
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