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Effect of transcranial direct current stimulation with concurrent cognitive performance targeting posterior parietal cortex vs prefrontal cortex on working memory in schizophrenia: a randomized clinical trial
Working memory deficits are linked to irregularities in the dorsolateral prefrontal cortex (DLPFC) and the posterior parietal cortex (PPC) in...
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‘Chile woke up’ (and I can fall asleep no more): The fantasmatic organisation of the desire for change
In this article, I adopt the psychoanalytic notion of fantasy to challenge mainstream conceptualisations of the desire for social change. Recent...
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Short-chain fatty acids suppresses astrocyte activation by amplifying Trp-AhR-AQP4 signaling in experimental autoimmune encephalomyelitis mice
The function of astrocytes in response to gut microbiota-derived signals has an important role in the pathophysiological processes of central nervous...
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Rapidly-manufactured CD276 CAR-T cells exhibit enhanced persistence and efficacy in pancreatic cancer
BackgroundPancreatic cancer is one of the most lethal malignancies and the lack of treatment options makes it more deadly. Chimeric Antigen Receptor...
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Genetic association study for three single nucleotide polymorphisms related to type 2 diabetes in Egyptian population
BackgroundDiabetes mellitus is a disease that may result from interaction between environmental factors and a strong genetic component. The current...
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Radiomic analysis reveals diverse prognostic and molecular insights into the response of breast cancer to neoadjuvant chemotherapy: a multicohort study
BackgroundBreast cancer patients exhibit various response patterns to neoadjuvant chemotherapy (NAC). However, it is uncertain whether diverse tumor...
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Nuclear translocation of ISG15 regulated by PPP2R2B inhibits cisplatin resistance of bladder cancer
Cisplatin resistance is a major challenge for systemic therapy against advanced bladder cancer (BC). Little information is available on the...
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Global incidence and characteristics of spinal cord injury since 2000–2021: a systematic review and meta-analysis
BackgroundThis study employs systematic review and meta-analysis to explore the incidence and characteristics of spinal cord injury (SCI) between...
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Vaginal and rectal microbiome contribute to genital inflammation in chronic pelvic pain
BackgroundChronic pelvic pain (CPP) is a multifactorial syndrome that can substantially affect a patient’s quality of life. Endometriosis is one...
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Surviving laryngotracheal mucormycosis: conquering central airway challenges
Laryngotracheal mucormycosis presents a rare but critical challenge, particularly in immunocompromised individuals. This report details the case of a...
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The combined association of physical activity and alcohol use with long-term mortality: an age-stratified analysis
BackgroundThe combined association of physical activity (PA) and alcohol use (AU) with long-term mortality is yet to be investigated.
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Treatment of chronic kidney disease in older populations
As the world population ages, an expected increase in the prevalence of chronic kidney disease (CKD) among older individuals will pose a considerable...
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Long-term severe hypoxia adaptation induces non-canonical EMT and a novel Wilms Tumor 1 (WT1) isoform
The majority of cancer deaths are caused by solid tumors, where the four most prevalent cancers (breast, lung, colorectal and prostate) account for...
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Cytotoxic T-lymphocyte-associated 4 protein expression is associated with a high international prognostic score in advanced-stage classical Hodgkin lymphoma
ObjectiveTwenty percent of all classical Hodgkin lymphoma (CHL) cases relapse and recur, especially in advanced stages with a high International...
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Evaluation of serum MicroRNA 21, MicroRNA 192 and serum TGFβ1 in type 2 diabetes mellitus patients and their relation to diabetic nephropathy
BackgroundDiabetic nephropathy (DN) is a frequent and long-lasting microvascular consequence that has an established connection with diabetes. It...
