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Microglia are dispensable for experience-dependent refinement of mouse visual circuitry
To test the hypothesized crucial role of microglia in the developmental refinement of neural circuitry, we depleted microglia from mice of both sexes...
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Selective anti-tumor activity of glutathione-responsive abasic site trap** agent in anaplastic thyroid carcinoma
Anaplastic thyroid carcinoma (ATC) is a rare but highly aggressive thyroid cancer with poor prognosis. Killing cancer cells by inducing DNA damage or...
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How to strengthen societal impact of research and innovation? Lessons learned from an explanatory research-on-research study on participatory knowledge infrastructures funded by the Netherlands Organization for Health Research and Development
BackgroundScientific research and innovation can generate societal impact via different pathways. Productive interactions, such as collaboration...
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Antiplatelet therapy to prevent ischemic events in giant cell arteritis: protocol for a systematic review and meta-analysis
BackgroundGiant cell arteritis (GCA) is the most common systemic vasculitis in adults. Presenting features include new-onset headaches,...
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Epidemiology, economic, and humanistic burden of hereditary angioedema: a systematic review
BackgroundThis systematic study aims to assess the global epidemiologic, economic, and humanistic burden of illness associated with all types of...
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A systematic review and meta-analysis of nonrelapse mortality after CAR T cell therapy
Although chimeric antigen receptor (CAR) T cell therapy represents a transformative immunotherapy, it is also associated with distinct toxicities...
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Telomere-to-telomere Citrullus super-pangenome provides direction for watermelon breeding
To decipher the genetic diversity within the cucurbit genus Citrullus , we generated telomere-to-telomere (T2T) assemblies of 27 distinct genotypes,...
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Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study
Pulsed field ablation (PFA) is an emerging technology for the treatment of atrial fibrillation (AF), for which pre-clinical and early-stage clinical...
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Bayesian estimation of gene constraint from an evolutionary model with gene features
Measures of selective constraint on genes have been used for many applications, including clinical interpretation of rare coding variants, disease...
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Automation of systematic reviews of biomedical literature: a sco** review of studies indexed in PubMed
BackgroundThe demand for high-quality systematic literature reviews (SRs) for evidence-based medical decision-making is growing. SRs are costly and...
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Explaining inequity in knowledge, attitude, and services related to HIV/AIDS: a systematic review
BackgroundEquitable service provision and coverage are important responses to end the threat of the HIV/AIDS pandemic. Understanding inequity...
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Antitumour effects of SFX-01 molecule in combination with ionizing radiation in preclinical and in vivo models of rhabdomyosarcoma
BackgroundDespite a multimodal approach including surgery, chemo- and radiotherapy, the 5-year event-free survival rate for rhabdomyosarcoma (RMS),...
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Cardiac effects of direct anti-viral treatment in type II diabetic patients with hepatitis C infection
BackgroundThe link between diabetes mellitus and chronic hepatitis C infection remains well established. It is estimated that up to one third of...
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Effect of transcranial direct current stimulation with concurrent cognitive performance targeting posterior parietal cortex vs prefrontal cortex on working memory in schizophrenia: a randomized clinical trial
Working memory deficits are linked to irregularities in the dorsolateral prefrontal cortex (DLPFC) and the posterior parietal cortex (PPC) in...
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‘Chile woke up’ (and I can fall asleep no more): The fantasmatic organisation of the desire for change
In this article, I adopt the psychoanalytic notion of fantasy to challenge mainstream conceptualisations of the desire for social change. Recent...
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Short-chain fatty acids suppresses astrocyte activation by amplifying Trp-AhR-AQP4 signaling in experimental autoimmune encephalomyelitis mice
The function of astrocytes in response to gut microbiota-derived signals has an important role in the pathophysiological processes of central nervous...
