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Guidelines for holistic integrative management of pancreatic cancer
BackgroundPancreatic cancer ranks 10 th in the incidence rate of malignant tumors in male, and 12 th in female. Pancreatic cancer is the sixth leading...
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The potential and translational application of infant genetic research
In the current genomic revolution, the infancy life stage is the most neglected. Although clinical genetics recognizes the value of early...
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A vagal–brainstem interoceptive circuit for cough-like defensive behaviors in mice
Coughing is a respiratory behavior that plays a crucial role in protecting the respiratory system. Here we show that the nucleus of the solitary...
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AI-based selection of individuals for supplemental MRI in population-based breast cancer screening: the randomized ScreenTrustMRI trial
Screening mammography reduces breast cancer mortality, but studies analyzing interval cancers diagnosed after negative screens have shown that many...
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Prognostic and clinicopathological significance of tertiary lymphoid structure in non-small cell lung cancer: a systematic review and meta-analysis
BackgroundNon-small cell lung cancer (NSCLC) is the primary reason for cancer-related deaths globally. Tertiary lymphoid structure (TLS) is an...
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Implementing immediate sequential bilateral cataract surgery at Buckinghamshire Healthcare NHS Trust
Background/ObjectivesImmediate sequential bilateral cataract surgery (ISBCS) was first introduced into NICE guidelines in 2017. In this approach,...
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Controlling Alzheimer’s disease by deep brain stimulation based on a data-driven cortical network model
This work aims to explore the control effect of DBS on Alzheimer's disease (AD) from a neurocomputational perspective. Firstly, a data-driven...
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Left atrial remodeling and voltage-guided ablation outcome in persistent atrial fibrillation patients according to CHA2DS2-VASc score
BackgroundCHA 2 DS 2 -VASc score-related differences have been reported in atrial fibrotic remodeling and prognosis of atrial fibrillation (AF) patients...
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Viabahn endoprosthesis for femoropopliteal aneurysm repair: safety, success rates, and long-term patency
BackgroundThe Viabahn endoprosthesis has become a vital option for endovascular therapy, yet there is limited long-term data on its effectiveness for...
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Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and kidney stone: evidence from NHANES 2007–2018
BackgroundAs an innovative lipid parameter, NHHR (the ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol) can...
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Effects of exercise on depression and anxiety in postmenopausal women: a pairwise and network meta-analysis of randomized controlled trials
BackgroundExercise has been identified as a promising non-pharmacological therapy for the management of depression, but there is still controversy...
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The applications of soil bin test facilities to terramechanics: a review
AbstractA soil bin test facility is a crucial tool for investigating the interaction between terrain and measuring devices under specific field...
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Metabolic engineering of terpene metabolism in lavender
BackgroundSeveral members of the Lamiaceae family of plants produce large amounts of essential oil [EO] that find extensive applications in the food,...
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The ethics of ChatGPT in medicine and healthcare: a systematic review on Large Language Models (LLMs)
With the introduction of ChatGPT, Large Language Models (LLMs) have received enormous attention in healthcare. Despite potential benefits,...
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Genetic association study for three single nucleotide polymorphisms related to type 2 diabetes in Egyptian population
BackgroundDiabetes mellitus is a disease that may result from interaction between environmental factors and a strong genetic component. The current...
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Rapidly-manufactured CD276 CAR-T cells exhibit enhanced persistence and efficacy in pancreatic cancer
BackgroundPancreatic cancer is one of the most lethal malignancies and the lack of treatment options makes it more deadly. Chimeric Antigen Receptor...
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Antitumour effects of SFX-01 molecule in combination with ionizing radiation in preclinical and in vivo models of rhabdomyosarcoma
BackgroundDespite a multimodal approach including surgery, chemo- and radiotherapy, the 5-year event-free survival rate for rhabdomyosarcoma (RMS),...
