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Cabozantinib and nivolumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial
Supplementation with CBM588, a bifidogenic live bacterial product, has been associated with improved clinical outcomes in persons with metastatic...
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Cancer metastasis through the lymphatic versus blood vessels
Whether cancer cells metastasize from the primary site to the distant sites via the lymphatic vessels or the blood vessels directly into the...
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BAG6 restricts pancreatic cancer progression by suppressing the release of IL33-presenting extracellular vesicles and the activation of mast cells
Recent studies reveal a critical role of tumor cell-released extracellular vesicles (EVs) in pancreatic cancer (PC) progression. However, driver...
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Single-cell transcriptomic profiling reveals decreased ER protein Reticulon3 drives the progression of renal fibrosis
Chronic kidney disease (CKD) poses a significant global health dilemma, emerging from complex causes. Although our prior research has indicated that...
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Leading Edge Techniques in the Quest for Characterizing Rare Hematopoietic Stem Cells
Purpose of ReviewHematopoietic stem cells (HSCs) occupy the summit of the intricate hematopoiesis hierarchy, constituting a mere 0.01% of the adult...
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A panoptic segmentation dataset and deep-learning approach for explainable scoring of tumor-infiltrating lymphocytes
Tumor-Infiltrating Lymphocytes (TILs) have strong prognostic and predictive value in breast cancer, but their visual assessment is subjective. To...
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Reciprocal regulation of T follicular helper cells and dendritic cells drives colitis development
The immunological mechanisms underlying chronic colitis are poorly understood. T follicular helper (T FH ) cells are critical in hel** B cells during...
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Adverse events during intravenous fosfomycin therapy in a real-life scenario. Risk factors and the potential role of therapeutic drug monitoring
BackgroundIntravenous fosfomycin (IVFOF) is gaining interest in severe infections. Its use may be limited by adverse events (AEs). Little experience...
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Exposure to second-hand smoke and breast cancer risk in non-smoking women: a comprehensive systematic review and meta-analysis
Through the use of an innovative method to identify original publications, we conducted a meta-analysis of all epidemiological studies evaluating the...
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Recurrence of oral squamous cell carcinoma in surgically treated patients at Khartoum Teaching Dental Hospital retrospective cross-sectional study
BackgroundIn terms of survival rate, recurrent oral squamous cell carcinoma (OSCC) after primary surgery is considered as a poor prognostic indicator.
...
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Synergy of retinoic acid and BH3 mimetics in MYC(N)-driven embryonal nervous system tumours
BackgroundCertain paediatric nervous system malignancies have dismal prognoses. Retinoic acid (RA) is used in neuroblastoma treatment, and...
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Impact of an intergenerational program to improve loneliness and social isolation in older adults initiated at the time of emergency department discharge: study protocol for a three-arm randomized clinical trial
BackgroundSocial isolation and loneliness (SIL) worsens mortality and other outcomes among older adults as much as smoking. We previously tested the...
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Cognitive training and promoting a healthy lifestyle for individuals with isolated REM sleep behavior disorder: study protocol of the delayed-start randomized controlled trial CogTrAiL-RBD
BackgroundIsolated REM sleep behavior disorder (iRBD) is an early α-synucleinopathy often accompanied by incipient cognitive impairment. As executive...
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Limited training and transfer effects in older and young adults who participated in 12 sessions of process-based working memory training. A three-armed pretest-posttest design study
ObjectiveNumerous studies confirm the effectiveness of cognitive training in older adults. However, there is limited evidence of the transfer...
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The effects of Quercetin on wound healing in the human umbilical vein endothelial cells
An injury that affects the integrity of the skin, either inside or externally, is called a wound. Damaged tissue is repaired by a set of cellular and...
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Comparative effectiveness of an individualized model of hemodialysis vs conventional hemodialysis: a study protocol for a multicenter randomized controlled trial (the TwoPlus trial)
BackgroundMost patients starting chronic in-center hemodialysis (HD) receive conventional hemodialysis (CHD) with three sessions per week targeting...
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Plasma metabolites in childhood Burkitt lymphoma cases and cancer-free controls in Uganda
IntroductionBurkitt lymphoma (BL) is an aggressive non-Hodgkin lymphoma associated with Plasmodium falciparum and Epstein-Barr virus, both of which...
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Designing optimal experiments in metabolomics
BackgroundMetabolomics data is often complex due to the high number of metabolites, chemical diversity, and dependence on sample preparation. This...
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Analyzing the impact of T7L variants overexpression on the metabolic profile of Escherichia coli
IntroductionExploring metabolic changes within host E. coli through an untargeted metabolomic study of T7L variants overexpression to optimize...
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Causal relationship between primary sclerosing cholangitis and systemic lupus erythematosus: a bidirectional Mendelian randomization study
BackgroundObservational studies have found a link between two autoimmune diseases, namely, primary sclerosing cholangitis (PSC) and systemic lupus...
