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Trastuzumab-Deruxtecan: Redefining HER2 as a Tumor Agnostic Biomarker
Trastuzumab deruxtecan (T-DXd) is an antibody-drug conjugate (ADC) targeting HER2-positive malignancies across various tumor types. Through its...
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Comprehensive multiomics analysis of the signatures of gastric mucosal bacteria and plasma metabolites across different stomach microhabitats in the development of gastric cancer
PurposeAs an important component of the microenvironment, the gastric microbiota and its metabolites are associated with tumour occurrence,...
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A skin-specific α-Synuclein seeding amplification assay for diagnosing Parkinson’s disease
The seeding amplification assay (SAA) has recently emerged as a valuable tool for detecting α-synuclein (αSyn) aggregates in various clinically...
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Morphological Characteristics of Colon Tumors in Mice with Different Tolerance to Hypoxia
In adult male C57BL/6 mice with high (HR) and low (LR) resistance to hypoxia, morphological features of colon tumors and blood parameters were...
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Skin-inspired interface modification strategy toward a structure-function integrated hybrid smart fabric system with self-powered sensing property for versatile applications
Fabric-based composites with superior mechanical properties and excellent perceptive function are highly desirable. However, it remains a huge...
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Analysis of Toxicity of Recombinant Pneumolysin from Streptococcus pneumoniae
We studied toxicity of recombinant Streptococcus pneumoniae pneumolysin protein in experiments on mice and its cytopathogenic effect on cultures of...
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Pilot Experiment on Non-Invasive Non-Thermal Disintegration of Human Mucinous Breast Carcinoma Ex Vivo Using Boiling Histotripsy
We present the results of a pilot study demonstrating the feasibility of non-invasive non-thermal disintegration of human mucinous carcinoma of the...
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Assessment of the Sensitivity of Foodborne Cronobacter spp. Strains and Other Enterobacteria to Temperature Stresses and Chlorine-Containing Biocides
We examined the effects of elevated temperatures and biocides on survivability of food isolates of Cronobacter spp. ( C. sakazakii ) and concomitant...
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Association between Ultradian Rhythms of Body Temperature in Small Mammals and Earth’s Crust Stress
Association was assessed between the data harvested by a long-baseline laser interference deformograph and the dynamics of body temperature (BT) in...
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Analysis of the Antimicrobial Activity of Epigallocatechin-3-Gallate (EGCG)
We studied antimicrobial activity of epigallocatechin-3-gallate (EGCG), a green tea polyphenolic catechin, and its combined use with ceftazidime...
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PEMOCS: Evaluating the effects of a concept-guided, PErsonalised, MOtor-Cognitive exergame training on cognitive functions and gait in chronic Stroke—study protocol for a randomised controlled trial
BackgroundMany stroke survivors remain with residual cognitive and motor impairments despite receiving timely acute and sub-acute rehabilitation....
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Extension of efficacy range for targeted malaria-elimination interventions due to spillover effects
Malaria-elimination interventions aim to extinguish hotspots and prevent transmission to nearby areas. Here, we re-analyzed a cluster-randomized...
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Striatal projection neurons coexpressing dopamine D1 and D2 receptors modulate the motor function of D1- and D2-SPNs
The role of the striatum in motor control is commonly assumed to be mediated by the two striatal efferent pathways characterized by striatal...
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Stretching intervention can prevent muscle injuries: a systematic review and meta-analysis
PurposePrevious meta-analysis studies concluded that static stretching intervention cannot decrease all-cause injury in healthy active individuals....
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Acute myeloid leukemia first presentation with central nervous system (CNS) involvement: a case report
BackgroundAcute myeloid leukemia (AML) typically presents with bone marrow myeloblast replacement, which can interfere with normal hematopoiesis. In...
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Site-specific genetic and functional signatures of aortic endothelial cells at aneurysm predilection sites in healthy and AngII ApoE−/− mice
Aortic aneurysm is characterized by a pathological dilation at specific predilection sites of the vessel and potentially results in life-threatening...
