We are improving our search experience. To check which content you have full access to, or for advanced search, go back to the old search.

Search

Please fill in this field.
Filters applied:
Biomedicine, general Human genetics

Search Results

Showing 1-20 of 10,000 results

  1. Lessons from the physiological role of guanosine in neurodegeneration and cancer: Toward a multimodal mechanism of action?

    Neurodegenerative diseases and brain tumours represent important health challenges due to their severe nature and debilitating consequences that...

    Carla Inês Tasca, Mariachiara Zuccarini, ... Francisco Ciruela in Purinergic Signalling
    Article 15 July 2024

  2. DAP12 interacts with RER1 and is retained in the secretory pathway before assembly with TREM2

    DNAX-activating protein of 12 kDa (DAP12) is a transmembrane adapter protein expressed in lymphoid and myeloid lineage cells. It interacts with...

    Yanxia Liu, Sandra Theil, ... Jochen Walter in Cellular and Molecular Life Sciences
    Article Open access 15 July 2024

  3. TOTEM: a multi-cancer detection and localization approach using circulating tumor DNA methylation markers

    Background

    Detection of cancer and identification of tumor origin at an early stage improve the survival and prognosis of patients. Herein, we...

    Dalin **ong, Tiancheng Han, ... Chunguang Li in BMC Cancer
    Article Open access 15 July 2024

  5. Impact on Glycemia Risk Index and other metrics in type 1 adult patients switching to Advanced Hybrid Closed-Loop systems: a one-year real-life experience

    Background

    Advanced Hybrid Closed-Loop system (AHCL) has profoundly changed type 1 diabetes therapy. This study primarily aimed to assess the impact...

    Eugenia Resmini, Emanuela Zarra, ... Angela Girelli in European Journal of Medical Research
    Article Open access 15 July 2024

  7. Unraveling the differential mechanisms of revascularization promoted by MSCs & ECFCs from adipose tissue or umbilical cord in a murine model of critical limb-threatening ischemia

    Background

    Critical limb-threatening ischemia (CLTI) constitutes the most severe manifestation of peripheral artery disease, usually induced by...

    Marta Rojas-Torres, Lucía Beltrán-Camacho, ... Ma. Carmen Duran-Ruiz in Journal of Biomedical Science
    Article Open access 15 July 2024

  8. Vitamin C inactivates c-Jun N-terminal kinase to stabilize heart and neural crest derivatives expressed 1 (Hand1) in regulating placentation and maintenance of pregnancy

    Vitamin C (VC) serves as a pivotal nutrient for anti-oxidation process, metabolic responses, and stem cell differentiation. However, its precise...

    Haibin Zhu, Huan Luo, ... Hongfeng Ruan in Cellular and Molecular Life Sciences
    Article Open access 15 July 2024

  9. Post-implantation analysis of genomic variations in the progeny from develo** fetus to birth

    The analysis of genomic variations in offspring after implantation has been infrequently studied. In this study, we aim to investigate the extent of de...

    Yingming Zheng, Chuan** Lin, ... Fan ** in Human Genomics
    Article Open access 15 July 2024

  10. Advanced Targeting Strategies for Murine Retroviral and Adeno-associated Viral Vectors

    Targeted gene delivery involves broadening viral tropism to infect previously nonpermissive cells, replacing viral tropism to infect a target cell...
    Julie H. Yu, David V. Schaffer in Gene Therapy and Gene Delivery Systems
    Chapter

  11. Nonviral Delivery of Cancer Genetic Vaccines

    The potential use of genetic vaccines to address numerous diseases including cancer is promising, but currently unrealized. Here, we review...
    Steven R. Little, Robert Langer in Gene Therapy and Gene Delivery Systems
    Chapter

  12. Production and Formulation of Adenovirus Vectors

    Adenovirus vectors have attracted considerable interest over the past decade, with ongoing clinical development programs for applications ranging...
    Nedim E. Altaras, John G. Aunins, ... Jayanthi J. Wolf in Gene Therapy and Gene Delivery Systems
    Chapter

  13. Molecular Conjugates

    Molecular conjugates are nanometer-sized entities consisting of synthetic materials (lipids, polycations, targeting agents, and so on) and nucleic...
    Jeremy Heidel, Swaroop Mishra, Mark E. Davis in Gene Therapy and Gene Delivery Systems
    Chapter

  14. Systemic interindividual DNA methylation variants in cattle share major hallmarks with those in humans

    Background

    We recently identified ~ 10,000 correlated regions of systemic interindividual epigenetic variation (CoRSIVs) in the human genome. These...

    Wen-Jou Chang, Maria S. Baker, ... Robert A. Waterland in Genome Biology
    Article Open access 15 July 2024

  15. YAP/TAZ interacts with RBM39 to confer resistance against indisulam

    The Hippo pathway and its downstream effectors, Yes-associated protein/transcriptional coactivator with PDZ-binding motif (YAP/TAZ), are essential...

    Toshinori Ando, Kento Okamoto, ... Mikihito Kajiya in Oncogenesis
    Article Open access 15 July 2024

  16. Adeno-associated Virus as a Gene Therapy Vector: Vector Development, Production and Clinical Applications

    Adeno-associated virus (AAV) has emerged as an attractive vector for gene therapy. AAV vectors have successfully been utilized to promote...
    Joshua C. Grieger, Richard J. Samulski in Gene Therapy and Gene Delivery Systems
    Chapter

  17. Lentiviral Vectors

    We review the use of lentiviral vectors in current human gene therapy applications that involve genetic modification of nondividing tissues with...
    Nils Loewen, Eric M. Poeschla in Gene Therapy and Gene Delivery Systems
    Chapter

  18. Plasmid Vaccines and Therapeutics: From Design to Applications

    In the late 1980s, Vical and collaborators discovered that the injection into tissues of unformulated plasmid encoding various proteins resulted in...
    Marston Manthorpe, Peter Hobart, ... Alain Rolland in Gene Therapy and Gene Delivery Systems
    Chapter

  19. Clinical characteristics and factors associated with survival rate of patients with non-muscle invasive bladder cancer attending at a Tertiary Hospital in Somalia

    Background

    A few studies regarding the epidemiology and risk factors of Non-muscle Invasive Bladder Cancer (NMIBC) are reported from Sub-Saharan...

    Abdikarim Hussein Mohamed, Khaled Ali Mohamed, ... Mohamed Abdikarim Nur-amin in BMC Cancer
    Article Open access 14 July 2024

  20. EGFR mutations induce the suppression of CD8+ T cell and anti-PD-1 resistance via ERK1/2-p90RSK-TGF-β axis in non-small cell lung cancer

    Background

    Non-small cell lung cancer (NSCLC) patients with EGFR mutations exhibit an unfavorable response to immune checkpoint inhibitor (ICI)...

    Huayan Huang, **aokuan Zhu, ... Shun Lu in Journal of Translational Medicine
    Article Open access 14 July 2024
Did you find what you were looking for? Share feedback.