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Development of a differential treatment selection model for depression on consolidated and transformed clinical trial datasets
Major depressive disorder (MDD) is the leading cause of disability worldwide, yet treatment selection still proceeds via “trial and error”. Given the...
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Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking
Individuals with schizophrenia frequently experience co-occurring substance use, including tobacco smoking and heavy cannabis use, and substance use...
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Inducing Death Thoughts Reduces the Cortisol Response to Psychosocial Stress Similar to the Effects of Early-life Adversity: A Life-history Perspective
PurposeEarly-life adversity (ELA) affects health by altering the hypothalamic–pituitary–adrenal (HPA) axis. Most studies show that ELA blunts HPA...
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Quality over quantity: powering neuroimaging samples in psychiatry
Neuroimaging has been widely adopted in psychiatric research, with hopes that these non-invasive methods will provide important clues to the...
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A review of diffusion MRI in mood disorders: mechanisms and predictors of treatment response
By measuring the molecular diffusion of water molecules in brain tissue, diffusion MRI (dMRI) provides unique insight into the microstructure and...
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Quantitative MRI at 7-Tesla reveals novel frontocortical myeloarchitecture anomalies in major depressive disorder
Whereas meta-analytical data highlight abnormal frontocortical macrostructure (thickness/surface area/volume) in Major Depressive Disorder (MDD), the...
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Racial and ethnic socioenvironmental inequity and neuroimaging in psychiatry: a brief review of the past and recommendations for the future
Neuroimaging is a major tool that holds immense translational potential for understanding psychiatric disorder phenomenology and treatment. However,...
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Evolutionary Adaptation Perspectives on Childcare with References to Life History Plasticity in the Modern World: Brazil, Russia, and the USA
IntroductionThe cooperative breeding framework suggests that help from extended family members with childrearing is important adaptation for our...
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NIMH perspectives on future directions in neuroimaging for mental health
NIMH’s mission is to transform the understanding and treatment of mental illnesses through basic and clinical research, paving the way for...
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Validation of a non-food or water motivated effort-based foraging task as a measure of motivational state in male mice
Disorders of motivation such as apathy syndrome are highly prevalent across neurological disorders but do not yet have an agreed treatment approach....
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Ketamine induced synaptic plasticity operates independently of long-term potentiation
Synaptic plasticity occurs via multiple mechanisms to regulate synaptic efficacy. Homeostatic and Hebbian plasticity are two such mechanisms by which...
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Identifying the role of (dis)inhibition in the vicious cycle of substance use through ecological momentary assessment and resting-state fMRI
Functional inhibition is known to improve treatment outcomes in substance use disorder (SUD), potentially through craving management enabled by...
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Chronic post-COVID neuropsychiatric symptoms persisting beyond one year from infection: a case-control study and network analysis
Our study aims to delineate the phenotypes of chronic neuropsychiatric symptoms among adult subjects recovering from their first COVID that occurred...
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Negative emotionality shapes the modulatory effects of ketamine and lamotrigine in subregions of the anterior cingulate cortex
Neuroimaging studies have identified the anterior cingulate cortex (ACC) as one of the major targets of ketamine in the human brain, which may be...
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Irritability in young people with copy number variants associated with neurodevelopmental disorders (ND-CNVs)
A range of rare mutations involving micro-deletion or -duplication of genetic material (copy number variants (CNVs)) have been associated with high...
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A novel blood-based epigenetic biosignature in first-episode schizophrenia patients through automated machine learning
Schizophrenia (SCZ) is a chronic, severe, and complex psychiatric disorder that affects all aspects of personal functioning. While SCZ has a very...
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Human Male Body Size Predicts Increased Knockout Power, Which Is Accurately Tracked by Conspecific Judgments of Male Dominance
Humans have undergone a long evolutionary history of violent agonistic exchanges, which would have placed selective pressures on greater body size...
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The single-cell opioid responses in the context of HIV (SCORCH) consortium
Substance use disorders (SUD) and drug addiction are major threats to public health, impacting not only the millions of individuals struggling with...
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