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Luteolin Mitigates D-Galactose-Induced Brain Ageing in Rats: SIRT1-Mediated Neuroprotection
Luteolin is an essential natural polyphenol found in a variety of plants. Numerous studies have supported its protective role in neurodegenerative...
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Lipidome changes due to improved dietary fat quality inform cardiometabolic risk reduction and precision nutrition
Current cardiometabolic disease prevention guidelines recommend increasing dietary unsaturated fat intake while reducing saturated fats. Here we use...
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Benmelstobart, anlotinib and chemotherapy in extensive-stage small-cell lung cancer: a randomized phase 3 trial
Immunochemotherapy is the first-line standard for extensive-stage small-cell lung cancer (ES-SCLC). Combining the regimen with anti-angiogenesis may...
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Adoptive transfer of personalized neoantigen-reactive TCR-transduced T cells in metastatic colorectal cancer: phase 2 trial interim results
Adoptive cell transfer (ACT) with neoantigen-reactive T lymphocytes can mediate cancer regression. Here we isolated unique, personalized,...
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Systematic Review and Meta-Analysis of the Diagnostic Accuracy of a Graded Gait and Truncal Instability Rating in Acutely Dizzy and Ataxic Patients
BackgroundIn patients presenting with acute prolonged vertigo and/or gait imbalance, the HINTS [Head-Impulse, Nystagmus, Test-of-Skew] are very...
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Paclitaxel in colon cancer management: from conventional chemotherapy to advanced nanocarrier delivery systems
Paclitaxel, a potent chemotherapeutic agent derived from the bark of the Pacific yew tree, has demonstrated significant efficacy in the treatment of...
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Attention-based cross-frequency graph convolutional network for driver fatigue estimation
Fatigue driving significantly contributes to global vehicle accidents and fatalities, making driver fatigue level estimation crucial....
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Decoding the Preparation Stage of Target Shooting under Audiovisual Restricted Conditions: Investigating Neural Mechanisms Using Microstate Analysis
Shooting is a fine sport that is greatly influenced by mental state, and the neural activity of brain in the preparation stage of shooting has a...
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HLA-DR3 ~ DQ2 associates with sensory neuropathy in paraneoplastic neurological syndromes with Hu antibodies
ObjectivesTo investigate the association between human leukocyte antigen (HLA) and paraneoplastic neurological syndromes (PNS) with Hu antibodies,...
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Two aspects of feed-forward control of action stability: effects of action speed and unexpected events
We explored two types of anticipatory synergy adjustments (ASA) during accurate four-finger total force production task. The first type is a change...
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Experimental Study of Needle Insertion into Gerbil Tympanic Membrane
The perforation characteristics and fracture-related mechanical properties of the tympanic membrane (TM) greatly affect surgical procedures like...
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Mystery of the Muenke midface: spheno-occipital synchondrosis fusion and craniofacial skeletal patterns
PurposeThe spheno-occipital synchondrosis (SOS) is an important site of endochondral ossification in the cranial base that closes prematurely in...
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Regulation of MicroRNAs After Spinal Cord Injury in Adult Zebrafish
Spinal cord injury (SCI) is a central nerve injury that often leads to loss of motor and sensory functions at or below the level of the injury....
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The Association Between Autism Symptomatology and Adaptive Functioning Over Six Months: Findings from the Pilot Phase of the PARC Study
PurposeIn the context of developmental trajectories, the association between adaptive functioning and core autism symptomatology remains unclear. The...
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Patterns of Pregabalin Users from Substance Abuse Treatment Facilities: Results from the French OPPIDUM Program from 2008 to 2022
IntroductionIn recent years, pregabalin has received growing attention due to its abuse liability. The aim of this study was to further characterize...
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Heterogeneity in choice models of addiction: the role of context
RationaleTheories of addiction guide scientific progress, funding priorities, and policy development and ultimately shape how people experiencing or...
