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PEGylation of Proteins as Tailored Chemistry for Optimized Bioconjugates
The high potential of peptides and proteins as therapeutic agents has not been fully exploited because of their common shortcomings: the only...
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Polymer Therapeutics for Cancer: Current Status and Future Challenges
Drug delivery systems for cancer therapeutics have revolutionized medicine. Delivery systems have improved the efficacy and reduced the toxicity of...
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Enzymatic Polymerization to Polysaccharides
Polysaccharides are formed by repeated glycosylations between a sugar donor and a sugar acceptor. This chapter reviews the in vitro synthesis of...
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Polymer Therapeutics: Polymers as Drugs, Drug and Protein Conjugates and Gene Delivery Systems: Past, Present and Future Opportunities
As the 21st century begins we are witnessing a paradigm shift in medical practice. Whereas the use of polymers in biomedical materials applications...
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Polypeptide and Polypeptide Hybrid Copolymer Synthesis via NCA Polymerization
This article summarizes recent developments in the synthesis of polypeptides and hybrid peptide copolymers. Traditional methods used to polymerize...
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Gene Delivery Using Polymer Therapeutics
The use of polymers as synthetic non-viral carriers for introducing nucleic acids into cells appears very appealing. Polymers can be generated in...
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Synthesis of Phenol Polymers Using Peroxidases
This chapter deals with the peroxidase-catalyzed polymerization of phenol and its derivatives. Such a polymerization needs an oxidation reagent,...
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Hydrogels for Musculoskeletal Tissue Engineering
The advancements in scaffold-supported cell therapy for musculoskeletal tissue engineering have been truly dramatic in the last couple of decades....
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Solution Properties of Polypeptide-based Copolymers
The aggregation behaviour of biomimetic polypeptide hybrid copolymers and copolypeptides is here reviewed with a particular eye on the occurrence...
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Nanostructured Devices Based on Block Copolymer Assemblies for Drug Delivery: Designing Structures for Enhanced Drug Function
Block copolymers spontaneously assemble into nanoscaled polymeric micelles, which have significant potential as drug carriers. Following much work...
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Analysis and Architecture of Clinical Workflow Systems using Agent-Oriented Lifecycle Models
Healthcare executives are grappling with a climate of great change in the healthcare industry. This is coming from a number of sources. First, there...
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Impedimetric Detection of DNA Hybridization: Towards Near-Patient DNA Diagnostics
Immobilization strategies for the attachment of nucleotide probes to both microarrays and microfabricated interdigitated electrodes differ to...
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Current Status of Computerized Decision Support Systems in Mammography
Breast cancer is one of the most devastating and deadly diseases for women today. Despite advances in cancer treatment, early mammographic detection...
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13 Usability of an Assistive Robot Manipulator: Toward a Quantitative User Evaluation
This chapter describes our research activity on the integration of a robotic arm in the environment of persons with disabilities. People who have...
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2 Rehabilitation Robotics from Past to Present – A Historical Perspective
Popular culture presents the image of a robot as a mechanical, humanoid device, often evil in intent. Those with a slightly more informed technical...
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12 Risk Reduction Mechanisms for Safe Rehabilitation Robots
Safety is one of the most important features of rehabilitation robots. However, strategies for safe rehabilitation robots are not yet clarified. A...
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4 Welfare-Oriented Service Robotic Systems: Intelligent Sweet Home & KARES II
Utopia – it would be a society where the welfare of the people is properly guaranteed. In the society, each constituent would live his/her life with...
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5 “FRIEND” – An Intelligent Assistant in Daily Life
The research and development in the field of rehabilitation robots produced a multiplicity of rehabilitation robots available as off-the- shelf...
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6 GIVING-A-HAND System: The Development of a Task-Specific Robot Appliance
The rapidly changing demographics in industrialized nations create a pressing need for effective personal assistive aids that appeal to elderly and...