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PEGylation of Proteins as Tailored Chemistry for Optimized Bioconjugates
The high potential of peptides and proteins as therapeutic agents has not been fully exploited because of their common shortcomings: the only...
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Polymer Therapeutics for Cancer: Current Status and Future Challenges
Drug delivery systems for cancer therapeutics have revolutionized medicine. Delivery systems have improved the efficacy and reduced the toxicity of...
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Enzymatic Polymerization to Polysaccharides
Polysaccharides are formed by repeated glycosylations between a sugar donor and a sugar acceptor. This chapter reviews the in vitro synthesis of...
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Polymer Therapeutics: Polymers as Drugs, Drug and Protein Conjugates and Gene Delivery Systems: Past, Present and Future Opportunities
As the 21st century begins we are witnessing a paradigm shift in medical practice. Whereas the use of polymers in biomedical materials applications...
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Polypeptide and Polypeptide Hybrid Copolymer Synthesis via NCA Polymerization
This article summarizes recent developments in the synthesis of polypeptides and hybrid peptide copolymers. Traditional methods used to polymerize...
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Gene Delivery Using Polymer Therapeutics
The use of polymers as synthetic non-viral carriers for introducing nucleic acids into cells appears very appealing. Polymers can be generated in...
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Synthesis of Phenol Polymers Using Peroxidases
This chapter deals with the peroxidase-catalyzed polymerization of phenol and its derivatives. Such a polymerization needs an oxidation reagent,...
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Solution Properties of Polypeptide-based Copolymers
The aggregation behaviour of biomimetic polypeptide hybrid copolymers and copolypeptides is here reviewed with a particular eye on the occurrence...
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Nanostructured Devices Based on Block Copolymer Assemblies for Drug Delivery: Designing Structures for Enhanced Drug Function
Block copolymers spontaneously assemble into nanoscaled polymeric micelles, which have significant potential as drug carriers. Following much work...
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Aid of Scaling Laws in the Achievement of a Well-Controlled Film Deposition Process
Scaling laws are profitably applied in all the scientific disciplines. Approximated solutions constitute a valuable aid for the analysis of complex...
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Vibrational Spectroscopy in Ion–Irradiated Carbon–Based Thin Films
In this work we present and discuss some selected experiments on ion–irradiated carbon–based thin films. Vibrational spectroscopy is used to...
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Laser Ablation-Deposited CN x Thin Films
Amorphous CN x thin films were deposited at room temperature by pulsed laser ablation of graphite targets in a...
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Elastic and Structural Properties of Carbon Materials Investigated by Brillouin Light Scattering
Brillouin light scattering (BS) is a nondestructive technique exploited to investigate collective excitations in solids: acoustic phonons, spin...
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Pulsed Laser Deposition of Carbon Films: Tailoring Structure and Properties
Pulsed laser deposition (PLD) is a versatile technique to synthesize films of a given material with strongly different properties. In this chapter we...
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Impedimetric Detection of DNA Hybridization: Towards Near-Patient DNA Diagnostics
Immobilization strategies for the attachment of nucleotide probes to both microarrays and microfabricated interdigitated electrodes differ to...
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Ion Microscopy on Diamond
Because of its physical properties (strong radiation hardness, wide energy gap with a consequent extremely low dark current, very large electron and...
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Raman Spectroscopy and Optical Properties of Amorphous Diamond-Like Carbon Films
The Raman spectroscopy and optical characterization of amorphous hydrogen-free diamond-like carbon films is described. The samples were prepared by...
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Correlation Between Local Structure and Film Properties in Amorphous Carbon Materials
A discussion of the various amorphous carbon and amorphous hydrogenated carbon films is presented. A link between sp 2, sp...
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Formation, Atomic Structures and Properties of Carbon Nanocage Materials
Various carbon nanocage fullerene materials (clusters, metallofullerenes, onions, nanotubes, nanohorns and nanocapsules) were synthesized by...