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Current Topics Regarding the Function of the Medial Temporal Lobe Memory System
The first clear insight that the medial temporal lobe of the human brain was in fact a system of anatomically connected structures that were...
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PET imaging of neuroinflammation: any credible alternatives to TSPO yet?
Over the last decades, the role of neuroinflammation in neuropsychiatric conditions has attracted an exponentially growing interest. A key driver for...
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Where do Harris’ Checkerspots Lay their Eggs and what are the Consequences?
Where a female lays her eggs has strong implications for the survival of her offspring, an impetus that takes on particular significance for species...
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A bipolar disorder-associated missense variant alters adenylyl cyclase 2 activity and promotes mania-like behavior
The single nucleotide polymorphism rs13166360, causing a substitution of valine (Val) 147 to leucine (Leu) in the adenylyl cyclase 2 (ADCY2), has...
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Evaluation of the Irrigation Water Quality of Beressa River, North West Ethiopia
Beressa River is facing a problem due to uncontrolled discharge of liquid wastes from domestics and industries. Therefore, the study was conducted to...
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Immune challenge reduces begging effort and modifies begging call structure in spotless starling nestlings
Symptoms of illness offer insights into an organism’s condition, altering social signals that affect others’ behavior. Nestling birds employ begging...
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Management of orofacial pain starts with careful differentiation of odontogenic and non-odontogenic pain
The diagnosis and management of orofacial pain can be challenging, especially when pain of non-odontogenic origin mimics dental pain or is localised...
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RET Inhibitors in RET Fusion-Positive Lung Cancers: Past, Present, and Future
While activating RET fusions are identified in various cancers, lung cancer represents the most common RET fusion-positive tumor. The clinical drug...
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Targeting DNA Damage Response Deficiency in Thoracic Cancers
Thoracic cancers comprise non-small cell lung cancers (NSCLCs), small cell lung cancers (SCLCs) and malignant pleural mesotheliomas (MPM)....
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Statistical Signal Detection Algorithm in Safety Data: A Proprietary Method Compared to Industry Standard Methods
IntroductionSeveral quantitative methods have been established, in pharmacovigilance, to detect signals of disproportionate reporting (SDRs) from...
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Multimodal training protocols on unstable rather than stable surfaces better improve dynamic balance ability in older adults
BackgroundThere has been growing interest in using unstable devices in training protocols. This study aimed to assess the effectiveness of two...
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Thiamylal serum concentration for refractory convulsive status epilepticus while associated decreased concentrations of concomitant antiepileptics: a case report
BackgroundTreating refractory status epilepticus (RSE) remains a challenge. Thiamylal can be used as a second- or third-line treatment; however, its...
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Estrogen receptor beta signaling enhances extinction memory recall for heroin-conditioned cues in a sex- and region-specific manner
Return to use, or relapse, is a major challenge in the treatment of opioid use disorder (OUD). Relapse can be precipitated by several factors,...
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Vitamin C Alleviates Neurobehavioral Deficits, IGF1 Expression, and Neuronal Damage Induced by Chronic Social Isolation Stress in the Hippocampus of Adult Male Rats
Social isolation stress (SIS) is associated with emotional and cognitive deficits. Here, we examined the impact of prolonged treatment with vitamin C...
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Trauma, adversity, and biological aging: behavioral mechanisms relevant to treatment and theory
Although stress and adversity are largely universal experiences, people exposed to greater hardship are at increased risk for negative health...
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Exploring factors associated with bleeding events after open heart surgery in patients on dialysis − effects of the presence or absence of warfarin therapy
BackgroundPerioperative management of patients on dialysis is critical for controlling bleeding and thrombotic risk, in addition to infection...
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Traditional Herbal Remedies Used in the Management of Urolithiasis by the Tribals of Purulia District, West Bengal, India
The tribal populations in Purulia district directly or indirectly rely on medicinal plants for their basic medical needs. Urolithiasis is the...
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Contribution of plasma levels of VEGF-A and angiopoietin-2 in addition to a genetic variant in KCNAB1 to predict the risk of bevacizumab-induced hypertension
Bevacizumab-induced hypertension poses a therapeutic challenge and identifying biomarkers for hypertension can enhance therapy safety. Lower plasma...
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Sleep profiles of different psychiatric traits
Disturbed sleep comes in many forms. While the key role of sleep in mental health is undisputed, our understanding of the type of slee** problems...
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