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Molecular Components of Physiological Stress Responses in Escherichia coli
In order to survive under and adapt to different conditions Escherichia coli has evolved elaborate systems that are able to sense and respond to...
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Cofactor Regeneration at the Lab Scale
Progress made in lab-scale applications of various coenzyme regeneration systems over the last two decades has mainly focused on the applications of...
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From Stationary to Instationary Metabolic Flux Analysis
Metabolic flux analysis using 13C labeled substrates is an important tool for metabolic engineering. Although it has now been evolving for more than...
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Applying Metabolic Profiling Techniques for Stimulus-Response Experiments: Chances and Pitfalls
So far it is mainly transcriptome and proteome analysis that has been applied to elucidate the correlation between genotype and phenotype although...
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Biochemical Reaction Engineering and Process Development in Anaerobic Wastewater Treatment
Developments in production technology have frequently resulted in the concentrated local accumulation of highly organic-laden wastewaters. Anaerobic...
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Biochemical Engineering Aspects of Expanded Bed Adsorption
The economic feasibility of a biotechnological production process is directly linked to the number and efficiency of the processes required during...
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Parallel Reactor Systems for Bioprocess Development
Controlled parallel bioreactor systems allow fed-batch operation at early stages of process development. The characteristics of shaken bioreactors...
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Stress Induced by Recombinant Protein Production in Escherichia coli
Strong production of recombinant proteins interferes with cellular processes in many ways. Drainage of precursors and energy urges the cell to...
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Roles of Heat-Shock Chaperones in the Production of Recombinant Proteins in Escherichia coli
Escherichia coli is a versatile organism for the production of recombinant proteins. Often, however, the recombinant protein does not reach its...
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Membrane Reactors at Degussa
The review covers the development of membrane reactor technologies at Degussa for the synthesis of fine chemicals. The operation of fed-batch or...
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Inclusion Bodies: Formation and Utilisation
The efficient in vivo folding of many heterologous proteins is a major bottleneck of high level production in bacterial hosts and simple optimisation...
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Monitoring of Stress Responses
New developments in the RNA analysis techniques now enable a comprehensive view on the bacterial physiology under bioprocess conditions. The DNA-chip...
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Analysis and Control of Proteolysis of Recombinant Proteins in Escherichia coli
Proteolysis is one of the reasons for poor production of recombinant proteins in Escherichia coli. Important properties of E. coli proteases, which...
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The Oxygen Mass Transfer, Carbon Dioxide Inhibition, Heat Removal, and the Energy and Cost Efficiencies of High Pressure Fermentation
This study focuses on the enhancement of oxygen transfer in aerobic fermentation processes through the use of the reactor headspace pressure as a...
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The Application of Multi-Parameter Flow Cytometry to Monitor Individual Microbial Cell Physiological State
The development of multi-parameter flow cytometric techniques in our laboratories has led to a functional classification of the physiological state...
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Technical Application of Biological Principles in Asymmetric Catalysis
The production of enantiopure compounds is becoming increasingly important to the chemical and biotechnological industries. Bioorganic...
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Enzyme-Catalyzed Regio- and Enantioselective Ketone Reductions
In this chapter, examples are given of the application of highly reactive prochiral ketones as substrates for enzymatic reductions....
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Extraction of Primary and Secondary Metabolites
Several new methods besides the usual organic solvent extraction have been developed over the last few years for the extraction of primary and...
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Oral Administration of Limosilactobacillus reuteri KBL346 Ameliorates Influenza Virus A/PR8 Infection in Mouse
Influenza virus infection is an important public-health concern because of its high transmissibility and potential for severe complications. To...
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Fenofibrate alleviates the composition and metabolic pathways of gut microbiota in high-fat diet treated hamsters
BackgroundFenofibrate is a compound with diverse biological properties that can be utilized to lower blood lipids. Understanding the impact of the...
